Arizona Diamondbacks vs San Francisco Giants Prediction & Picks - MLB

Prediction published on 9/17/25, 11:51 AM  by Carlos Zabala | Modified on 10/2/25 at 6:30 PM in MLB Picks

A high-stakes series involving two teams on the verge of the playoffs, the Diamondbacks and the Giants, is taking place in the desert. For now, Arizona is getting the better of it. They won Monday's game 8-1 as a -123 betting favorite. Tuesday's game was thrilling. The D-backs won 6-5 on a walk-off hit by Jordan Lawlar.

With this, the Diamondbacks have won their last four games. Despite the Mets' triumph in their last two, they closed the gap. Arizona is only 1.5 games out of the final Wild Card spot, even though they positioned themselves as sellers at the trade deadline and let Naylor and Suárez walk.

Still, the D-backs can always count on Carroll, the D-backs' RF and third-string hitter, who went 3-for-5 in Tuesday's win; since September 30, Carroll has had five multi-hit games. Ketel Marte, batting second in the order, also went 2-for-5 in the last win, and Geraldo Perdomo, batting leadoff, has had a furious September and is on a seven-game hitting streak.

The Giants' disappointment must be immense after losing the second game of the series, in which they led 4-0 in the first inning. Veteran Justin Verlander is scheduled to pitch for the Giants in Game 3. The former Cy Young Award winner is the oldest active pitcher in MLB; he managed to lower his ERA to 3.94 after three convincing performances, but his record remains poor this year at 3-10.