New York Giants vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

New York Giants
11/2/25 13:00
San Francisco 49ers

Prediction:

 

49ers -2.5

-115
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 by Travis Pulver | in NFL Picks

The San Francisco 49ers will try to get back on track this week when they head east to take on the New York Giants at MetLife Stadium in East Rutherford, NJ. Kickoff for this NFC battle is scheduled to take place at 1 p.m. EST and the game will be broadcast on CBS.

The 49ers are coming off a surprising loss to the Houston Texans, 26-15. Christian McCaffrey and the run game were shut down; McCaffrey had just eight carries for 25 yards. Mac Jones and the passing game were not too much better. He went 19-32 for 191 yards, two touchdowns, and a pick. Houston has the No. 1 defense in the league, so that part wasn’t too surprising, but then C.J. Stroud dominated the 49ers' defense, throwing for 318 yards and two scores while the run game chipped in 157 yards. As for the Giants, they had a pretty rough day against the Eagles, losing Cam Skattebo to a season-ending injury. Saquon Barkley had his best day of the season with 150 yards on the ground, and Jalen Hurts had four touchdown passes.

The 49ers opened as 2.5-point road favorites over the Giants and will likely head into Sunday as such.

New York Giants vs San Francisco 49ers Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
28 New York Giants
0.235 17 4 13

New York Giants and San Francisco 49ers Latest Matches

New York Giants
New York Giants Latest matches
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 26, 2025 - NFL

Philadelphia Eagles
38 :  20
New York Giants

Oct 19, 2025 - NFL

Denver Broncos
33 :  32
New York Giants

Oct 9, 2025 - NFL

New York Giants
34 :  17
Philadelphia Eagles

Oct 5, 2025 - NFL

New Orleans Saints
26 :  14
New York Giants

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 9, 2025 - NFL

New York Giants
34 :  17
Philadelphia Eagles

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

New York Giants
14 :  35
Baltimore Ravens

Dec 8, 2024 - NFL

New York Giants
11 :  14
New Orleans Saints
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Oct 26, 2025 - NFL

Philadelphia Eagles
38 :  20
New York Giants

Oct 19, 2025 - NFL

Denver Broncos
33 :  32
New York Giants

Oct 5, 2025 - NFL

New Orleans Saints
26 :  14
New York Giants

Sep 14, 2025 - NFL

Dallas Cowboys
40 :  37
New York Giants

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants
San Francisco 49ers
San Francisco 49ers Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 19, 2025 - NFL

San Francisco 49ers
20 :  10
Atlanta Falcons

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 12, 2025 - NFL

Tampa Bay Buccaneers
30 :  19
San Francisco 49ers

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

New York Giants against San Francisco 49ers : Head to Head (H2H)

New York Giants

0 %

San Francisco 49ers

100 %

Sep 21, 2023 - NFL

San Francisco 49ers
30 :  12
New York Giants

New York Giants - San Francisco 49ers Key Points

  1. San Francisco leads the all-time series vs. the Giants 22-21; the 49ers have won three of the last four meetings.
  2. Both teams are 4-4 ATS.
  3. The OVER is 4-3-1 for the 49ers and 4-4 for the Giants.
  4. Betting Public: 65% of spread tickets and 48% of the handle are on the 49ers (-2.5).

Our New York Giants vs San Francisco 49ers Prediction

This is not the San Francisco team that has been dominant in years past. No, the defense is nothing special, the offense struggles to establish the run (yes, even with Christian McCaffrey), and they have been very inconsistent this season. Jaxson Dart has breathed new life into the Giants since taking over as QB1, but he’ll miss Cam Skattebo. I’m not sure what we’ll see out of the Giants' offense, but I feel confident Mac Jones will have a solid day and lead the 49ers to victory.

Our 49ers vs. Giants Pick: San Francisco -2.5

Prediction:

 

49ers -2.5

-115
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

New York Giants vs San Francisco 49ers Picks