San Francisco 49ers vs New York Giants Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
11/2/25 13:00
New York Giants

Prediction:

 

49ers -2.5

-115
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 by Travis Pulver in NFL Picks

The San Francisco 49ers will try to get back on track this week when they head east to take on the New York Giants at MetLife Stadium in East Rutherford, NJ. Kickoff for this NFC battle is scheduled to take place at 1 p.m. EST and the game will be broadcast on CBS.

The 49ers are coming off a surprising loss to the Houston Texans, 26-15. Christian McCaffrey and the run game were shut down; McCaffrey had just eight carries for 25 yards. Mac Jones and the passing game were not too much better. He went 19-32 for 191 yards, two touchdowns, and a pick. Houston has the No. 1 defense in the league, so that part wasn’t too surprising, but then C.J. Stroud dominated the 49ers' defense, throwing for 318 yards and two scores while the run game chipped in 157 yards. As for the Giants, they had a pretty rough day against the Eagles, losing Cam Skattebo to a season-ending injury. Saquon Barkley had his best day of the season with 150 yards on the ground, and Jalen Hurts had four touchdown passes.

The 49ers opened as 2.5-point road favorites over the Giants and will likely head into Sunday as such.

San Francisco 49ers vs New York Giants Form

Table

Teams % P W D L
12
San Francisco 49ers
San Francisco 49ers
0.625 8 5 0 3
27
New York Giants
New York Giants
0.25 8 2 0 6

San Francisco 49ers and New York Giants Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
W W L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers
W L L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Dec 30, 2024 - NFL

Detroit Lions
40 :  34
San Francisco 49ers

Dec 12, 2024 - NFL

Los Angeles Rams
12 :  6
San Francisco 49ers

Dec 8, 2024 - NFL

Chicago Bears
13 :  38
San Francisco 49ers
L L W W W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Oct 2, 2025 - NFL

San Francisco 49ers
26 :  23
Los Angeles Rams

Sep 14, 2025 - NFL

San Francisco 49ers
26 :  21
New Orleans Saints

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals
New York Giants
New York Giants Latest matches
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Oct 26, 2025 - NFL

New York Giants
20 :  38
Philadelphia Eagles

Oct 19, 2025 - NFL

New York Giants
32 :  33
Denver Broncos

Oct 9, 2025 - NFL

Philadelphia Eagles
17 :  34
New York Giants

Oct 5, 2025 - NFL

New York Giants
14 :  26
New Orleans Saints

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants
L L W L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Oct 9, 2025 - NFL

Philadelphia Eagles
17 :  34
New York Giants

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Baltimore Ravens
35 :  14
New York Giants

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Oct 26, 2025 - NFL

New York Giants
20 :  38
Philadelphia Eagles

Oct 19, 2025 - NFL

New York Giants
32 :  33
Denver Broncos

Oct 5, 2025 - NFL

New York Giants
14 :  26
New Orleans Saints

Sep 14, 2025 - NFL

New York Giants
37 :  40
Dallas Cowboys

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 5, 2025 - NFL

New York Giants
13 :  20
Philadelphia Eagles

San Francisco 49ers against New York Giants : Head to Head (H2H)

San Francisco 49ers

100 %

Draw

0 %

New York Giants

0 %

Sep 21, 2023 - NFL

New York Giants
12 :  30
San Francisco 49ers

Sep 27, 2020 - NFL

San Francisco 49ers
36 :  9
New York Giants

San Francisco 49ers - New York Giants Key Points

  1. San Francisco leads the all-time series vs. the Giants 22-21; the 49ers have won three of the last four meetings.
  2. Both teams are 4-4 ATS.
  3. The OVER is 4-3-1 for the 49ers and 4-4 for the Giants.
  4. Betting Public: 65% of spread tickets and 48% of the handle are on the 49ers (-2.5).

Our San Francisco 49ers vs New York Giants Prediction

This is not the San Francisco team that has been dominant in years past. No, the defense is nothing special, the offense struggles to establish the run (yes, even with Christian McCaffrey), and they have been very inconsistent this season. Jaxson Dart has breathed new life into the Giants since taking over as QB1, but he’ll miss Cam Skattebo. I’m not sure what we’ll see out of the Giants' offense, but I feel confident Mac Jones will have a solid day and lead the 49ers to victory.

Our 49ers vs. Giants Pick: San Francisco -2.5

Prediction:

 

49ers -2.5

-115
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San Francisco 49ers vs New York Giants Picks