Buffalo Bills vs Kansas City Chiefs Prediction & Picks - NFL

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Buffalo Bills
11/2/25 16:25
Kansas City Chiefs

Prediction:

 

Bills ML

+116
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 by Travis Pulver | in NFL Picks

The Kansas City Chiefs will try to extend their winning streak to four in a row when they head to the Empire State this week to face the Buffalo Bills at Highmark Stadium in Orchard Park, NY. Kickoff for this AFC battle is scheduled for 4:25 p.m. EST, and the game will be broadcast on CBS.

This may be the most anticipated game of the regular season. For most of the season, it has appeared as though the Chiefs’ dominance may be coming to an end, following less-than-stellar performances in several games. In light of last season's offensive struggles, it did not look promising. But then they got Xavier Worthy and Rashee Rice back, spurring a three-game winning streak. However, to be fair, the win over the Lions is the only respectable one; dominating the Raiders is not hard to do, and the Commanders were without Jayden Daniels. But if they were to beat the Bills…As for Buffalo, James Cook carried them to a win last week against the Panthers to end a two-game losing streak. The defense has struggled against the run, but they were able to keep Chuba Hubbard and Rico Dowdle from breaking out. Buffalo’s defense will have its work cut out for it against a resurgent Kansas City offense.

Buffalo Bills vs Kansas City Chiefs Form

Table

Teams Pts P W L
8 Buffalo Bills
0.706 17 12 5
24 Kansas City Chiefs
0.353 17 6 11

Buffalo Bills and Kansas City Chiefs Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens

Jan 19, 2025 - NFL

Buffalo Bills
27 :  25
Baltimore Ravens

Jan 12, 2025 - NFL

Buffalo Bills
31 :  7
Denver Broncos
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills

Dec 15, 2024 - NFL

Detroit Lions
42 :  48
Buffalo Bills
Kansas City Chiefs
Kansas City Chiefs Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 27, 2025 - NFL

Kansas City Chiefs
28 :  7
Washington Commanders

Oct 19, 2025 - NFL

Kansas City Chiefs
31 :  0
Las Vegas Raiders

Oct 12, 2025 - NFL

Kansas City Chiefs
30 :  17
Detroit Lions

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs

Sep 28, 2025 - NFL

Kansas City Chiefs
37 :  20
Baltimore Ravens

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 27, 2025 - NFL

Kansas City Chiefs
28 :  7
Washington Commanders

Oct 19, 2025 - NFL

Kansas City Chiefs
31 :  0
Las Vegas Raiders

Oct 12, 2025 - NFL

Kansas City Chiefs
30 :  17
Detroit Lions

Sep 28, 2025 - NFL

Kansas City Chiefs
37 :  20
Baltimore Ravens

Sep 14, 2025 - NFL

Kansas City Chiefs
17 :  20
Philadelphia Eagles

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Feb 9, 2025 - NFL

Philadelphia Eagles
40 :  22
Kansas City Chiefs

Jan 5, 2025 - NFL

Denver Broncos
38 :  0
Kansas City Chiefs

Dec 25, 2024 - NFL

Pittsburgh Steelers
10 :  29
Kansas City Chiefs

Buffalo Bills against Kansas City Chiefs : Head to Head (H2H)

Buffalo Bills

60 %

Kansas City Chiefs

40 %

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Nov 17, 2024 - NFL

Buffalo Bills
30 :  21
Kansas City Chiefs

Jan 21, 2024 - NFL

Buffalo Bills
24 :  27
Kansas City Chiefs

Dec 10, 2023 - NFL

Kansas City Chiefs
17 :  20
Buffalo Bills

Oct 16, 2022 - NFL

Kansas City Chiefs
20 :  24
Buffalo Bills

Buffalo Bills - Kansas City Chiefs: Form Analysis

Kansas City Chiefs

Fans are understandably excited about Xavier Worthy returning to the lineup a couple of weeks ago and Rashee Rice making his first start last week after serving a suspension, but the Chiefs will be without a key player in this game —running back Isiah Pacheco. The team's bread and butter is still the passing game, but the threat of a respectable rushing attack helps keep defenses honest and not going all out to rush Mahomes. Kareem Hunt will probably take over the lead back role.

Buffalo Bills vs Kansas City Chiefs Picks

Buffalo Bills & Kansas City Chiefs Squad Analysis

Buffalo Bills

The defense has taken a hit over the last week due to injuries, with Ed Oliver being placed on IR, and Shaq Thompson (LB) and Daquan Jones (DT) being ruled out this week. Wide receiver Joshua Palmer has been ruled out for Sunday as well.  

Buffalo Bills - Kansas City Chiefs Key Points

  1. Buffalo leads the all-time series against Kansas City 30-26-1; the Chiefs have won two of the last three, but the two teams are 5-5 in their last ten meetings.
  2. Buffalo is 3-4 ATS; Kansas City is 5-3 ATS.
  3. The OVER is 5-3 for the Bills and 3-5 for the Chiefs.
  4. Betting Public: 54% of moneyline tickets and 86% of the handle are on the Chiefs.

Our Buffalo Bills vs Kansas City Chiefs Prediction

This is a tough one. It is hard not to think that the Chiefs are back to their dominant ways, but I’m not ready to sign off on their return to dominance after three wins, with only one being against a good team. I’ve got a little more faith in Josh Allen and James Cook getting the job done at home than I do in the Chiefs' offense at the moment. As a home dog, I can’t pass the Bills up.

Our Kansas City vs. Buffalo Pick: Bills ML

Prediction:

 

Bills ML

+116
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Buffalo Bills vs Kansas City Chiefs - Other Interesting Picks

Josh Allen, Anytime Touchdown

Odds +105

Allen and the Bills have no problem calling his number when the Buffalo offense gets within striking distance. He had two last week against the Panthers and has had one in each of his last four games vs. the Chiefs. KC does not have a great run defense, so there is a good chance the Bills try to take advantage of it. It's surprising to see this market at plus money odds, making it hard to pass this one up.

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.