Los Angeles Rams vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Los Angeles Rams
9/22/24 16:25
San Francisco 49ers

Prediction:

 

49ers -6.5

-105
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 by Dan Angell in NFL Picks

The San Francisco 49ers (1-1 SU, 1-1 ATS) visit the Los Angeles Rams (0-2 SU, 0-2 ATS), a visit that has historically meant a lot of trouble for the home team. The Rams did a lot of losing to the 49ers in the 1980s and 1990s, and the bad old times are here again for them.

The 49ers are 9-2 in this matchup over the past five seasons, and the one regular season win for the Rams didn’t really count, as San Francisco had locked up the No. 1 seed and had turned the team over to the backups. Of course, the Rams have the one thing the 49ers have really wanted over the past few seasons: a Super Bowl trophy. Los Angeles’ other win in this series was the 2022 NFC championship game, and the Rams then followed by winning the Super Bowl, a fact that has burned the 49ers.

Los Angeles Rams vs San Francisco 49ers Form

Table

Teams Pts P W L
12 Los Angeles Rams
0.588 17 10 7
22 San Francisco 49ers
0.353 17 6 11

Los Angeles Rams and San Francisco 49ers Latest Matches

Los Angeles Rams
Los Angeles Rams Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 15, 2024 - NFL

Arizona Cardinals
41 :  10
Los Angeles Rams

Sep 8, 2024 - NFL

Detroit Lions
26 :  20
Los Angeles Rams

Jan 14, 2024 - NFL

Detroit Lions
24 :  23
Los Angeles Rams

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams

Dec 31, 2023 - NFL

New York Giants
25 :  26
Los Angeles Rams

Dec 21, 2023 - NFL

Los Angeles Rams
30 :  22
New Orleans Saints
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 21, 2023 - NFL

Los Angeles Rams
30 :  22
New Orleans Saints

Dec 3, 2023 - NFL

Los Angeles Rams
36 :  19
Cleveland Browns

Nov 19, 2023 - NFL

Los Angeles Rams
17 :  16
Seattle Seahawks

Sep 17, 2023 - NFL

Los Angeles Rams
23 :  30
San Francisco 49ers

Nov 13, 2022 - NFL

Los Angeles Rams
17 :  27
Arizona Cardinals

Oct 30, 2022 - NFL

Los Angeles Rams
14 :  31
San Francisco 49ers
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 15, 2024 - NFL

Arizona Cardinals
41 :  10
Los Angeles Rams

Sep 8, 2024 - NFL

Detroit Lions
26 :  20
Los Angeles Rams

Jan 14, 2024 - NFL

Detroit Lions
24 :  23
Los Angeles Rams

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams

Dec 31, 2023 - NFL

New York Giants
25 :  26
Los Angeles Rams

Dec 10, 2023 - NFL

Baltimore Ravens
37 :  31
Los Angeles Rams
San Francisco 49ers
San Francisco 49ers Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 15, 2024 - NFL

Minnesota Vikings
23 :  17
San Francisco 49ers

Sep 9, 2024 - NFL

San Francisco 49ers
32 :  19
New York Jets

Feb 11, 2024 - NFL

Kansas City Chiefs
25 :  22
San Francisco 49ers

Jan 28, 2024 - NFL

San Francisco 49ers
34 :  31
Detroit Lions

Jan 20, 2024 - NFL

San Francisco 49ers
24 :  21
Green Bay Packers

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 9, 2024 - NFL

San Francisco 49ers
32 :  19
New York Jets

Jan 28, 2024 - NFL

San Francisco 49ers
34 :  31
Detroit Lions

Jan 20, 2024 - NFL

San Francisco 49ers
24 :  21
Green Bay Packers

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams

Dec 25, 2023 - NFL

San Francisco 49ers
19 :  33
Baltimore Ravens

Nov 19, 2023 - NFL

San Francisco 49ers
27 :  14
Tampa Bay Buccaneers
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 15, 2024 - NFL

Minnesota Vikings
23 :  17
San Francisco 49ers

Feb 11, 2024 - NFL

Kansas City Chiefs
25 :  22
San Francisco 49ers

Dec 31, 2023 - NFL

Washington Commanders
10 :  27
San Francisco 49ers

Dec 17, 2023 - NFL

Arizona Cardinals
29 :  45
San Francisco 49ers

Dec 3, 2023 - NFL

Philadelphia Eagles
19 :  42
San Francisco 49ers

Nov 23, 2023 - NFL

Seattle Seahawks
13 :  31
San Francisco 49ers

Los Angeles Rams against San Francisco 49ers : Head to Head (H2H)

Los Angeles Rams

40 %

San Francisco 49ers

60 %

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams

Sep 17, 2023 - NFL

Los Angeles Rams
23 :  30
San Francisco 49ers

Oct 30, 2022 - NFL

Los Angeles Rams
14 :  31
San Francisco 49ers

Oct 3, 2022 - NFL

San Francisco 49ers
24 :  9
Los Angeles Rams

Jan 30, 2022 - NFL

Los Angeles Rams
20 :  17
San Francisco 49ers

Los Angeles Rams - San Francisco 49ers Key Points

  1. The 49ers are 7-2 ATS in the past nine meetings.
  2. The over is 3-0 in the past three meetings.
  3. The Rams have lost three straight games overall.
  4. The 49ers are 1-5 ATS in their past six games.

Our Los Angeles Rams vs San Francisco 49ers Prediction

This also might be the opponent that San Francisco needs, as the 49ers have been winning and playing far too many close games as of late. Out of San Francisco’s past six games, five of them were decided by six points or less (the exception, of course, was the one cover against the Jets). The 49ers have done well at winning tight games, but they could really use a blowout.

It might happen against the Rams, who looked terrible against Arizona. Los Angeles couldn’t stop anything in that game, as the Cardinals picked them to pieces in a 41-10 rout. While Arizona might be better than in past years, Los Angeles’ defense ranks dead last in the NFL and has never done well against San Francisco. With the 49ers entering with a point to prove after a loss to Minnesota, this appears a bad spot for Los Angeles. Our prediction for San Francisco vs. Los Angeles is 49ers -6.5.

Prediction:

 

49ers -6.5

-105
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Rams vs San Francisco 49ers Picks