Houston Texans vs San Francisco 49ers Prediction & Picks - NFL
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by Matt Lowrimore | in NFL Picks
Week 8 of the NFL will continue on Sunday with a matchup between the Houston Texans and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Texans and the 49ers.
San Francisco enters this game with a record of 5-2, having most recently beaten the Atlanta Falcons in Week 7 by a score of 20-10. The 49ers’ offense had a total of 324 yards, while its defense allowed 292 yards. Quarterback Mac Jones threw for 152 yards and one interception, while running back Christian McCaffrey led the team in rushing with 129 yards and two touchdowns.
As for Houston, they enter this game with a record of 2-4, having most recently lost to the Seattle Seahawks in Week 7 by a score of 27-19. The Texans’ offense had a total of 254 yards, while its defense allowed 316 yards. Quarterback C.J. Stroud threw for 229 yards, one touchdown, and one interception, while also leading the team in rushing with 25 yards.
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Houston Texans vs San Francisco 49ers Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
6
|
0.706 | 17 | 12 | 5 |
|
7
|
0.706 | 17 | 12 | 5 |
Houston Texans and San Francisco 49ers Latest Matches
2/6 (33%)
4/6 (67%)
Oct 20, 2025 - NFL
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Sep 28, 2025 - NFL
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3/6 (50%)
3/6 (50%)
Sep 28, 2025 - NFL
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Dec 25, 2024 - NFL
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2/6 (33%)
4/6 (67%)
Oct 20, 2025 - NFL
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Jan 18, 2025 - NFL
Jan 5, 2025 - NFL
4/6 (67%)
2/6 (33%)
Oct 19, 2025 - NFL
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Sep 14, 2025 - NFL
3/6 (50%)
3/6 (50%)
Oct 19, 2025 - NFL
Sep 28, 2025 - NFL
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Dec 30, 2024 - NFL
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3/6 (50%)
3/6 (50%)
Oct 12, 2025 - NFL
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Dec 22, 2024 - NFL
Houston Texans - San Francisco 49ers Key Points
- San Francisco is 4-3 ATS this season
- San Francisco is averaging 20.7 points per game this season
- Houston is 2-4 ATS this season
- Houston is averaging 21.2 points per game this season
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Our Houston Texans vs San Francisco 49ers Prediction
Houston is the small favorite in this game, which is a bit surprising given that they have a poor record this season. The Texans only have wins against an even worse Tennessee Titans team and a Baltimore Ravens team that was missing Lamar Jackson.
San Francisco, on the other hand, is playing like one of the top teams in the NFC. This is especially true given that Christian McCaffrey just had a 200+ yard game from scrimmage.
The Texans have simply been too inconsistent to trust, especially as a favorite. For that reason, our Houston Texans vs San Francisco 49ers prediction is: San Francisco 49ers ML.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
