Arizona Cardinals vs San Francisco 49ers Prediction & Picks - NFL
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by Bill Christy | in NFL Picks
While the top two teams will be playing for the NFC West division lead this weekend, the other two teams will also be facing off in the division. The San Francisco 49ers (6-4) will visit the Arizona Cardinals (3-6) this Sunday. The Niners know that if they win, they will be even with the loser of the Rams vs Seahawks game for 2nd place in the division. This is a rematch between these teams, as they previously played back in late September. In that contest, the Niners pulled out a 16-15 win at home. In that game, it was Kyler Murray starting for the Cardinals and Mac Jones starting for the Niners. This time, it is likely to be Jacoby Brissett for the Cardinals and Brock Purdy for the Niners. Mac Jones has done a terrific job in place of the injured Purdy, compiling over 2000 passing yards and 13 touchdown passes. However, the team is just hanging around .500 with him at the helm. Niners fans are hoping a return of Purdy will signal a return to winning streaks. For the Cardinals, things have gotten bleak. They have lost 6 of their last 7 games and now will be playing without their top wideout as Marvin Harrison Jr is out after an appendectomy.Limited Offer. Currently at DraftKings
Arizona Cardinals vs San Francisco 49ers Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.706 | 17 | 12 | 5 |
|
30
|
0.176 | 17 | 3 | 14 |
Arizona Cardinals and San Francisco 49ers Latest Matches
1/6 (17%)
5/6 (83%)
Nov 9, 2025 - NFL
Nov 3, 2025 - NFL
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3/6 (50%)
3/6 (50%)
Oct 19, 2025 - NFL
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Sep 25, 2025 - NFL
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Jan 5, 2025 - NFL
Dec 15, 2024 - NFL
2/6 (33%)
4/6 (67%)
Nov 9, 2025 - NFL
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Dec 28, 2024 - NFL
3/6 (50%)
3/6 (50%)
Nov 9, 2025 - NFL
Nov 2, 2025 - NFL
Oct 26, 2025 - NFL
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Oct 2, 2025 - NFL
2/6 (33%)
4/6 (67%)
Nov 9, 2025 - NFL
Oct 19, 2025 - NFL
Sep 28, 2025 - NFL
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Dec 30, 2024 - NFL
Dec 12, 2024 - NFL
4/6 (67%)
2/6 (33%)
Nov 2, 2025 - NFL
Oct 26, 2025 - NFL
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Oct 2, 2025 - NFL
Sep 14, 2025 - NFL
Sep 7, 2025 - NFL
Arizona Cardinals against San Francisco 49ers : Head to Head (H2H)
33 %
67 %
Sep 21, 2025 - NFL
Jan 5, 2025 - NFL
Oct 6, 2024 - NFL
Dec 17, 2023 - NFL
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Nov 21, 2022 - NFL
Arizona Cardinals - San Francisco 49ers Key Points
- SF is 3-8 ATS in its last 11 games against an opponent in the NFC West
- SF is 1-4 ATS in its last 5 games played in November.
- SF is 3-10 ATS in its last 13 games played on a Sunday when playing on the road.
- Arizona is is 9-2 ATS in its last 11 games when playing as the underdog.
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Our Arizona Cardinals vs San Francisco 49ers Prediction
This line has trap written all over it. We are seeing over 70% of the public bets coming in on the Niners and with no Harrison Jr, it is likely that number will grow. Purdy is likely to have some rust and lean on Christian McCaffery more than normal. The Cardinals will obviously know that and be prepared to load the box against him and force Purdy to throw more than he is comfortable with coming back from injury. We like the Cardinals to cover this one and potentially win outright at home.
Our prediction for Arizona Cardinals vs San Francisco 49ers: Arizona +3
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
