St. Louis Cardinals vs San Diego Padres Prediction & Picks - MLB
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by Travis Pulver | in MLB Picks
The St. Cardinals and San Diego Padres will get a four-game series underway today with Game One at Busch Stadium in St. Louis, Missouri. It is one of just five MLB games on the schedule for today and gets underway at 7:45 p.m. EST.
San Diego has been on the road since play resumed following the All-Star break; they went 2-1 in Washington but dropped their last time to Miami after winning the opener. The Cardinals have also been on the road since play resumed and did not do well, losing five of six games. Yu Darvish will get the nod for the Padres today. Darvish has only appeared in three games since returning from injury, and things have not gone well for the veteran righty. He has yet to record a win, going 0-2 in his three starts (two at home), has an ERA of 6.08, a WHIP of 1.50, and a .260 OBA. Darvish has yet to give up a home run. As for the Cardinals, they are scheduled to start Sonny Gray. Gray is 9-4 on the year in 20 starts with an ERA of 4.04, a WHIP of 1.15, and a .255 OBA. He has been at his best at home, where he is 6-1 in 12 starts with a 2.84 ERA and .249 OBA.
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St. Louis Cardinals vs San Diego Padres Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.556 | 162 | 90 | 72 |
|
20
|
0.481 | 162 | 78 | 84 |
St. Louis Cardinals and San Diego Padres Latest Matches
1/6 (17%)
5/6 (83%)
Jul 23, 2025 - MLB
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4/6 (67%)
2/6 (33%)
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1/6 (17%)
5/6 (83%)
Jul 23, 2025 - MLB
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3/6 (50%)
3/6 (50%)
Jul 23, 2025 - MLB
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2/6 (33%)
4/6 (67%)
Jul 13, 2025 - MLB
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3/6 (50%)
3/6 (50%)
Jul 23, 2025 - MLB
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St. Louis Cardinals against San Diego Padres : Head to Head (H2H)
67 %
33 %
Aug 29, 2024 - MLB
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Sep 22, 2022 - MLB
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May 15, 2021 - MLB
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St. Louis Cardinals - San Diego Padres Key Points
- St. Louis leads the all-time series vs. San Diego 312-216.
- The Cardinals are 29-20 at home; the Padres are 24-29 on the road.
- The Padres would claim a wildcard spot if the postseason were to start today; the Cardinals are 3.5 games back.
- Betting Public: 60% of TOTAL tickets and 64% of the handle are on the OVER.
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Our St. Louis Cardinals vs San Diego Padres Prediction
Darvish was once an ace, but certainly hasn’t looked like one this season. Gray has had a solid season and has pitched well at home, but across four starts in July, he has a 7.64 ERA. San Diego has hit .241 since the break; the Cardinals have hit .264. However, the Padres have scored 24 runs, while the Cards have scored just 17 (in six games). If I were to pick a winner, I’d lean towards the Padres, but the TOTAL is the best bet in this case. With two capable lineups going up against hittable pitchers, I’ll take the OVER.
Our Padres vs. Cardinals Pick: OVER 8
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
