Seattle Mariners vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Seattle Mariners
5/16/26 19:15
San Diego Padres

Prediction:

 

UNDER 7.5

-124
$350 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver | in MLB Picks

The Seattle Mariners (22-24, 12-12 Home) will try to get back on the right side of the scoreboard today when they host the San Diego Padres (26-18, 13-8 Away) in Game Two of a three-game weekend series. Fans can follow the action at Petco Park in San Diego on MLB.TV once the game gets underway at 7:15 p.m. EST.

Seattle came into the series having won three of four against the Astros in Houston, but dropped Game One of the series to the Padres yesterday, 2-0. For the Padres, it was a much-needed win after dropping two of three vs. the Bucks in Milwaukee earlier in the week.

Logan Gilbert is scheduled to get the start for the Mariners. Gilbert is 2-3 in nine starts with a 3.78 ERA and a 1.16 WHIP.  He has not done his best work at home, where he is 2-2 in six starts with a 4.91 ERA and a .278 OBA. Seven of the eight home runs he has surrendered came in home games.

As for the Padres, San Diego is scheduled to start Walker Buehler. He is 2-2 in nine starts with a 5.20 ERA and a 1.35 WHIP. He has been dreadful on the road, where he is 1-1 in three starts with a 10.13 ERA and a .360 OBA. However, he has only allowed three home runs all season.

Seattle Mariners vs San Diego Padres Form

Table

Teams Pts P W L
8 San Diego Padres
0.531 81 43 38
13 Seattle Mariners
0.5 84 42 42

Seattle Mariners and San Diego Padres Latest Matches

Seattle Mariners
Seattle Mariners Latest matches
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners

May 11, 2026 - MLB

Houston Astros
1 :  3
Seattle Mariners

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 6, 2026 - MLB

Seattle Mariners
3 :  1
Atlanta Braves

May 5, 2026 - MLB

Seattle Mariners
2 :  3
Atlanta Braves

May 4, 2026 - MLB

Seattle Mariners
5 :  4
Atlanta Braves

May 3, 2026 - MLB

Seattle Mariners
1 :  4
Kansas City Royals

May 2, 2026 - MLB

Seattle Mariners
2 :  3
Kansas City Royals

May 1, 2026 - MLB

Seattle Mariners
6 :  7
Kansas City Royals
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners

May 11, 2026 - MLB

Houston Astros
1 :  3
Seattle Mariners

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners
San Diego Padres
San Diego Padres Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Milwaukee Brewers
7 :  1
San Diego Padres

May 13, 2026 - MLB

Milwaukee Brewers
1 :  3
San Diego Padres

May 12, 2026 - MLB

Milwaukee Brewers
6 :  4
San Diego Padres

May 10, 2026 - MLB

San Diego Padres
3 :  2
St. Louis Cardinals

May 9, 2026 - MLB

San Diego Padres
4 :  2
St. Louis Cardinals

May 8, 2026 - MLB

San Diego Padres
0 :  6
St. Louis Cardinals
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 10, 2026 - MLB

San Diego Padres
3 :  2
St. Louis Cardinals

May 9, 2026 - MLB

San Diego Padres
4 :  2
St. Louis Cardinals

May 8, 2026 - MLB

San Diego Padres
0 :  6
St. Louis Cardinals

May 7, 2026 - MLB

San Diego Padres
1 :  2
St. Louis Cardinals

May 3, 2026 - MLB

San Diego Padres
4 :  3
Chicago White Sox

May 2, 2026 - MLB

San Diego Padres
0 :  4
Chicago White Sox
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Milwaukee Brewers
7 :  1
San Diego Padres

May 13, 2026 - MLB

Milwaukee Brewers
1 :  3
San Diego Padres

May 12, 2026 - MLB

Milwaukee Brewers
6 :  4
San Diego Padres

May 6, 2026 - MLB

San Francisco Giants
1 :  5
San Diego Padres

May 5, 2026 - MLB

San Francisco Giants
5 :  10
San Diego Padres

May 4, 2026 - MLB

San Francisco Giants
3 :  2
San Diego Padres

Seattle Mariners against San Diego Padres : Head to Head (H2H)

Seattle Mariners

0 %

San Diego Padres

100 %

Apr 16, 2026 - MLB

San Diego Padres
5 :  2
Seattle Mariners

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Mar 23, 2026 - MLB Spring Training

San Diego Padres
10 :  3
Seattle Mariners

Mar 17, 2026 - MLB Spring Training

Seattle Mariners
6 :  9
San Diego Padres

Mar 5, 2026 - MLB Spring Training

Seattle Mariners
6 :  27
San Diego Padres

Seattle Mariners - San Diego Padres Key Points

  1. Seattle leads the all-time series vs. San Diego, 73-68.
  2. San Diego is 23-20 ATS (run line) this season; Seattle is 17-29.
  3. The OVER is 18-24-2 for San Diego and 20-25-1 for Seattle.
  4. Betting Public: 38% of total tickets and 40% of the handle are on the UNDER.

Our Seattle Mariners vs San Diego Padres Prediction

It is easy to look at Buehler’s numbers overall and think he’ll get lit up by the Mariners lineup, leading to Seattle covering the run line. But the Mariners' offense has not been great over the last week (.244 BA and just over four runs per game). As bad as his aggregate numbers look, Buehler has not been terrible in recent starts. However, his lineup has been bad, generating just 13 runs over the last week (five games) while hitting .204. Despite his struggles at home, Gilbert is a decent pitcher. So, I’d lean towards Seattle winning, but I’m more confident that neither team will score much.

Our San Diego vs. Seattle Pick: UNDER 7.5

Prediction:

 

UNDER 7.5

-124
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Seattle Mariners vs San Diego Padres Picks