Seattle Mariners vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Seattle Mariners
5/15/26 21:40
San Diego Padres

Prediction:

 

Under 7.5 points

-112
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 by Carlos Zabala | in MLB Picks

Did the series in Houston ignite the offensive spark the Mariners were looking for? At least Luke Raley did, with a three-run homer in the first inning. Garver, who replaced the injured Raleigh, hit his first home run of the season, and the Mariners defeated the Astros 8-3, taking the final game of the series. One game away from tying their 22-23 record, the Mariners return to Seattle to await the Padres.

This series between the Mariners and Padres is generating a lot of interest. Earlier in the season, they faced off at Petco Park. In that series, the Padres swept the Mariners. In the second game, the Padres staged an epic comeback in the ninth inning thanks to a walk-off home run by Merrill. In that memorable game, the pitching matchup was Hancock vs. Vasquez, the same one that will take place this Friday at T-Mobile Park.

Randy Vasquez has a 4-1 record and a 3.05 ERA in 44.1 innings pitched. This performance is very similar to Hancock's, who boasts a 3-1 record and a 3.21 ERA. However, Hancock has a better K/BB ratio, with 50 strikeouts this season and only 9 walks.

Seattle Mariners vs San Diego Padres Form

Table

Teams Pts P W L
15 San Diego Padres
0.5 96 48 48
16 Seattle Mariners
0.495 97 48 49

Seattle Mariners and San Diego Padres Latest Matches

Seattle Mariners
Seattle Mariners Latest matches
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners

May 11, 2026 - MLB

Houston Astros
1 :  3
Seattle Mariners

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 6, 2026 - MLB

Seattle Mariners
3 :  1
Atlanta Braves

May 5, 2026 - MLB

Seattle Mariners
2 :  3
Atlanta Braves

May 4, 2026 - MLB

Seattle Mariners
5 :  4
Atlanta Braves

May 3, 2026 - MLB

Seattle Mariners
1 :  4
Kansas City Royals

May 2, 2026 - MLB

Seattle Mariners
2 :  3
Kansas City Royals

May 1, 2026 - MLB

Seattle Mariners
6 :  7
Kansas City Royals
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Houston Astros
3 :  8
Seattle Mariners

May 13, 2026 - MLB

Houston Astros
4 :  3
Seattle Mariners

May 12, 2026 - MLB

Houston Astros
2 :  10
Seattle Mariners

May 11, 2026 - MLB

Houston Astros
1 :  3
Seattle Mariners

May 10, 2026 - MLB

Chicago White Sox
2 :  1
Seattle Mariners

May 9, 2026 - MLB

Chicago White Sox
6 :  1
Seattle Mariners
San Diego Padres
San Diego Padres Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Milwaukee Brewers
7 :  1
San Diego Padres

May 13, 2026 - MLB

Milwaukee Brewers
1 :  3
San Diego Padres

May 12, 2026 - MLB

Milwaukee Brewers
6 :  4
San Diego Padres

May 10, 2026 - MLB

San Diego Padres
3 :  2
St. Louis Cardinals

May 9, 2026 - MLB

San Diego Padres
4 :  2
St. Louis Cardinals

May 8, 2026 - MLB

San Diego Padres
0 :  6
St. Louis Cardinals
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 10, 2026 - MLB

San Diego Padres
3 :  2
St. Louis Cardinals

May 9, 2026 - MLB

San Diego Padres
4 :  2
St. Louis Cardinals

May 8, 2026 - MLB

San Diego Padres
0 :  6
St. Louis Cardinals

May 7, 2026 - MLB

San Diego Padres
1 :  2
St. Louis Cardinals

May 3, 2026 - MLB

San Diego Padres
4 :  3
Chicago White Sox

May 2, 2026 - MLB

San Diego Padres
0 :  4
Chicago White Sox
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2026 - MLB

Milwaukee Brewers
7 :  1
San Diego Padres

May 13, 2026 - MLB

Milwaukee Brewers
1 :  3
San Diego Padres

May 12, 2026 - MLB

Milwaukee Brewers
6 :  4
San Diego Padres

May 6, 2026 - MLB

San Francisco Giants
1 :  5
San Diego Padres

May 5, 2026 - MLB

San Francisco Giants
5 :  10
San Diego Padres

May 4, 2026 - MLB

San Francisco Giants
3 :  2
San Diego Padres

Seattle Mariners against San Diego Padres : Head to Head (H2H)

Seattle Mariners

0 %

San Diego Padres

100 %

Apr 16, 2026 - MLB

San Diego Padres
5 :  2
Seattle Mariners

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Mar 23, 2026 - MLB Spring Training

San Diego Padres
10 :  3
Seattle Mariners

Mar 17, 2026 - MLB Spring Training

Seattle Mariners
6 :  9
San Diego Padres

Mar 5, 2026 - MLB Spring Training

Seattle Mariners
6 :  27
San Diego Padres
Seattle Mariners vs San Diego Padres Picks

Seattle Mariners - San Diego Padres Key Points

  1. The Padres' collective batting average is the second lowest in MLB in 2022
  2. The Mariners' FLD percentage is the third best in MLB
  3. The Mariners have a 12-11 home record
  4. The Padres are coming off a series loss in Milwaukee against the Brewers

Our Seattle Mariners vs San Diego Padres Prediction

In a rotation that looked like it would be the most dominant in MLB, Emerson Hancock was the least talked-about starter. But while Castillo, Gilbert, and Woo have had a mediocre 2026, Hancock has been the pleasant surprise of Seattle's pitching staff.

At home, Hancock is pitching particularly well. In May, he pitched at T-Mobile Park against the Royals, throwing seven innings and racking up an incredible 14 strikeouts without issuing a walk. If the Padres' offense lets him settle on the mound, they'll be in trouble on Friday.

Our prediction for Mariners vs Padres is: Under 7.5 runs.

Prediction:

 

Under 7.5 points

-112
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