Seattle Mariners vs San Diego Padres Prediction & Picks - MLB

Prediction published on 8/26/25, 6:01 PM  by Lou Aguila | Modified on 9/1/25 at 1:02 AM in MLB Picks

Listed at -115, the Seattle Mariners will attempt to push their win streak against the San Diego Padres to six games in Game 2 of their series on Tuesday at T-Mobile Park.

The Mariners extended their head-to-head dominance over the Padres, capturing their fifth straight win over the No.2 team in the NL West behind a prolific scoring night from their offense. Seattle improved its slate to 71-61, trailing the 72-59 Houston Astros – the current pace-setters in the AL West - by 1.5 games with barely a month left in the regular season. Averaging 4.6 runs per game this season, the Mariners have already scored 20 runs in their last two games.

The Padres’ elite pitching has been nonexistent in their last two games. San Diego conceded nine runs to the Mariners in Game 1, roughly 24 hours after surrendering eight runs in a 2-8 loss to the Los Angeles Dodgers in their series finale. San Diego boasts a 3.59 ERA in their last five games, but that figure dipped over the last five games to 4.50 ERA following two consecutive bad nights on the bump.