San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
9/13/26 19:20
San Diego Padres

Prediction:

 

Padres -1.5

+136
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 by Travis Pulver in MLB Picks

The San Francisco Giants (62-87, 36-38 Home) will try to avoid getting swept by San Diego (80-68, 34-39 Away) when they host the Padres at Oracle Park today at 7:20 p.m. EST, with coverage provided by Peacock.

San Francisco trailed early in Friday’s game, 7-1 after three. While they added four in the fifth, neither team scored the rest of the way. They jumped out to a 2-0 lead after the first yesterday, but the Padres slowly built a 7-3 lead after seven. The Giants tried to mount a comeback but fell short, scoring three in the eighth; final score-- 7-6.

Logan Webb is scheduled to get the start for the Giants. Webb has gone 8-8 in 26 starts with a complete game, an ERA of 4.10, and a WHIP of 1.15. Teams have hit .236 against him this season. But when pitching at home, he has gone 4-4 in 14 starts with a 3.26 ERA and a .222 OBA.

San Diego is expected to give Nick Pivetta the ball to start the day. Pivetta has gone 2-2 in five starts with a 3.43 ERA. 0.95 WHIP, and teams have hit just .182 against him. In his only other road start, he went five innings and gave up two runs on four hits and a walk with eight strikeouts.

San Francisco Giants vs San Diego Padres Form

Table

Teams Pts P W L
9 San Diego Padres
0.541 148 80 68
27 San Francisco Giants
0.416 149 62 87

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 6, 2026 - MLB

New York Mets
4 :  2
San Francisco Giants
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Aug 29, 2026 - MLB

San Francisco Giants
7 :  2
Arizona Diamondbacks
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 6, 2026 - MLB

New York Mets
4 :  2
San Francisco Giants

Sep 5, 2026 - MLB

New York Mets
5 :  9
San Francisco Giants

Sep 4, 2026 - MLB

New York Mets
10 :  6
San Francisco Giants

Sep 3, 2026 - MLB

Pittsburgh Pirates
5 :  2
San Francisco Giants

Sep 2, 2026 - MLB

Pittsburgh Pirates
4 :  5
San Francisco Giants

Sep 1, 2026 - MLB

Pittsburgh Pirates
13 :  12
San Francisco Giants
San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals

Sep 7, 2026 - MLB

San Diego Padres
3 :  2
Washington Nationals

Sep 6, 2026 - MLB

San Diego Padres
4 :  3
New York Yankees
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals

Sep 7, 2026 - MLB

San Diego Padres
3 :  2
Washington Nationals

Sep 6, 2026 - MLB

San Diego Padres
4 :  3
New York Yankees

Sep 5, 2026 - MLB

San Diego Padres
1 :  5
New York Yankees

Sep 4, 2026 - MLB

San Diego Padres
3 :  2
New York Yankees
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 2, 2026 - MLB

Cincinnati Reds
7 :  3
San Diego Padres

Sep 1, 2026 - MLB

Cincinnati Reds
4 :  3
San Diego Padres

Aug 31, 2026 - MLB

Cincinnati Reds
0 :  5
San Diego Padres

Aug 30, 2026 - MLB

Tampa Bay Rays
5 :  4
San Diego Padres

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

17 %

San Diego Padres

83 %

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Aug 2, 2026 - MLB

San Diego Padres
5 :  4
San Francisco Giants

Aug 1, 2026 - MLB

San Diego Padres
6 :  5
San Francisco Giants

Jul 31, 2026 - MLB

San Diego Padres
7 :  0
San Francisco Giants

Jul 30, 2026 - MLB

San Diego Padres
1 :  4
San Francisco Giants
San Francisco Giants vs San Diego Padres Picks

San Francisco Giants - San Diego Padres Key Points

  1. Over the last three seasons, San Diego has gone 25-13 vs. the Giants.
  2. San Francisco is 40-34 ATS (run line) at home; San Diego is 40-31 ATS (run line) on the road.
  3. The OVER is 35-35-4 for the Giants at home and 34-37 for the Padres on the road.
  4. Betting Public: 72% of run line tickets an 46% of the handle are on the Padres.

Our San Francisco Giants vs San Diego Padres Prediction

San Francisco has put up a good fight over the last two games, only to fall short in the end. But I don’t think it'll get to that point today. Webb does not have the toolset to slow down a lineup hitting as well as San Diego is right now (.305 BA over the last week). Pivetta got hit hard in his first outing (March 26 vs. Detroit) but allowed just two runs in four starts, both coming in the same game.  He’ll keep the Giants lineup in check for as long as he’s left in, with the bullpen bringing it home in a dominant win.

Our Padres vs. Giants Pick: Padres -1.5

Prediction:

 

Padres -1.5

+136
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.