San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
9/12/26 16:05
San Diego Padres

Prediction:

 

San Francisco Giants +1.5

-120
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 by Matt Lowrimore | in MLB Picks

A full 15-game MLB slate is scheduled for Saturday, one of which will feature a National League West Division matchup between the San Diego Padres and the San Francisco Giants. Let’s take a look at the match statistics and predictions for this game between the Padres and the Giants.

San Diego enters this game fighting for a playoff spot, as they are currently in second place in the National League West Division and also currently hold the third NL Wild-Card spot. Set to start this game for the Padres will be Michael King, who has an ERA of 3.00 this season. King has been serviceable on the road this season, but has not faced the Giants.

As for San Francisco, they enter this game having already been eliminated from the playoffs and, as such, are currently in fourth place in the National League West Division. Starting this game for the Giants will be Cesar Perdomo, who has an ERA of 0.90. Note that Perdomo has had limited appearances this season; however, from what we have seen, it looks likely that he will continue to impress.

San Francisco Giants vs San Diego Padres Form

Table

Teams Pts P W L
9 San Diego Padres
0.537 147 79 68
27 San Francisco Giants
0.419 148 62 86

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Sep 6, 2026 - MLB

New York Mets
4 :  2
San Francisco Giants

Sep 5, 2026 - MLB

New York Mets
5 :  9
San Francisco Giants

Sep 4, 2026 - MLB

New York Mets
10 :  6
San Francisco Giants
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals

Aug 29, 2026 - MLB

San Francisco Giants
7 :  2
Arizona Diamondbacks

Aug 29, 2026 - MLB

San Francisco Giants
1 :  7
Arizona Diamondbacks

Aug 28, 2026 - MLB

San Francisco Giants
6 :  10
Arizona Diamondbacks
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 6, 2026 - MLB

New York Mets
4 :  2
San Francisco Giants

Sep 5, 2026 - MLB

New York Mets
5 :  9
San Francisco Giants

Sep 4, 2026 - MLB

New York Mets
10 :  6
San Francisco Giants

Sep 3, 2026 - MLB

Pittsburgh Pirates
5 :  2
San Francisco Giants

Sep 2, 2026 - MLB

Pittsburgh Pirates
4 :  5
San Francisco Giants

Sep 1, 2026 - MLB

Pittsburgh Pirates
13 :  12
San Francisco Giants
San Diego Padres
San Diego Padres Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals

Sep 7, 2026 - MLB

San Diego Padres
3 :  2
Washington Nationals

Sep 6, 2026 - MLB

San Diego Padres
4 :  3
New York Yankees

Sep 5, 2026 - MLB

San Diego Padres
1 :  5
New York Yankees

Sep 4, 2026 - MLB

San Diego Padres
3 :  2
New York Yankees
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 9, 2026 - MLB

San Diego Padres
9 :  2
Washington Nationals

Sep 8, 2026 - MLB

San Diego Padres
5 :  4
Washington Nationals

Sep 7, 2026 - MLB

San Diego Padres
3 :  2
Washington Nationals

Sep 6, 2026 - MLB

San Diego Padres
4 :  3
New York Yankees

Sep 5, 2026 - MLB

San Diego Padres
1 :  5
New York Yankees

Sep 4, 2026 - MLB

San Diego Padres
3 :  2
New York Yankees
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 2, 2026 - MLB

Cincinnati Reds
7 :  3
San Diego Padres

Sep 1, 2026 - MLB

Cincinnati Reds
4 :  3
San Diego Padres

Aug 31, 2026 - MLB

Cincinnati Reds
0 :  5
San Diego Padres

Aug 30, 2026 - MLB

Tampa Bay Rays
5 :  4
San Diego Padres

Aug 29, 2026 - MLB

Tampa Bay Rays
7 :  6
San Diego Padres

Aug 28, 2026 - MLB

Tampa Bay Rays
9 :  4
San Diego Padres

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

17 %

San Diego Padres

83 %

Aug 2, 2026 - MLB

San Diego Padres
5 :  4
San Francisco Giants

Aug 1, 2026 - MLB

San Diego Padres
6 :  5
San Francisco Giants

Jul 31, 2026 - MLB

San Diego Padres
7 :  0
San Francisco Giants

Jul 30, 2026 - MLB

San Diego Padres
1 :  4
San Francisco Giants

May 6, 2026 - MLB

San Francisco Giants
1 :  5
San Diego Padres

May 5, 2026 - MLB

San Francisco Giants
5 :  10
San Diego Padres
San Francisco Giants vs San Diego Padres Picks

San Francisco Giants - San Diego Padres Key Points

  1. Michael King has an ERA of 3.00 this season
  2. Michael King has an ERA of 3.29 on the road this season
  3. Cesar Perdomo has an ERA of 0.90 this season
  4. Cesar Perdomo has not pitched at home this season

Our San Francisco Giants vs San Diego Padres Prediction

San Diego is the clear favorite in this game; however, San Francisco looks to be the best betting option. Not counting Friday’s game, the Giants have had some success against the Padres this season, winning four of the 10 meetings. Two of their losses to San Diego have been by just one run as well. 

It is true that Perdomo has yet to pitch at home this season, but he has still allowed just one earned run over 10.0 innings. King, on the other hand, has made 14 away starts this season, having allowed 30 runs (29 earned) over 79.1 innings.

Ultimately, the Giants have generally played the Padres well this season; therefore, our San Diego Padres vs. San Francisco Giants prediction is: San Francisco Giants +1.5.

Prediction:

 

San Francisco Giants +1.5

-120
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.