San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
6/5/25 15:45
San Diego Padres

Prediction:

 

Under 7.5

-125
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 by Carlos Zabala | in MLB Picks

The Padres took Game 1 and Game 2 in the San Francisco Bay Area, with Pivetta pitching. It was thought they also had a good chance of winning Game 3, but that proved not to be the case. The Giants won Game 3 6-5 with pregame odds of +101. They rallied to close out a 0-5 deficit, with the Padres leading in the top of the fifth inning. Pivetta had a good day early on, but it got worse when he got to the midway point, and the Giants' bats were able to figure him out. Chapman's 11th home run of the season got the Giants back in the game, and with a three-run home run in the bottom of the seventh inning, they sealed the final score at 6-5.

For Game 4 the Giants now seem to have the advantage in the pitching duel; until recently Robbie Ray had the best record for a pitcher in the MLB with 7-0, and he pitched very well in his last outing against the Marlins in Miami, where he threw 7 innings, struck out 9 and still ended up scoring his first L. Robbie Ray has 78 strikeouts with the Giants this season, the same number that Dylan Cease, who will start for the Padres, achieved, but with a worse record of 1-4.

San Francisco Giants vs San Diego Padres Form

Table

Teams Pts P W L
7 San Diego Padres
0.556 162 90 72
16 San Francisco Giants
0.5 162 81 81

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 27, 2025 - MLB

Detroit Tigers
3 :  1
San Francisco Giants

May 26, 2025 - MLB

Detroit Tigers
3 :  1
San Francisco Giants

May 25, 2025 - MLB

Washington Nationals
2 :  3
San Francisco Giants

May 24, 2025 - MLB

Washington Nationals
3 :  0
San Francisco Giants

May 21, 2025 - MLB

San Francisco Giants
4 :  8
Kansas City Royals

May 20, 2025 - MLB

San Francisco Giants
3 :  2
Kansas City Royals
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 21, 2025 - MLB

San Francisco Giants
4 :  8
Kansas City Royals

May 20, 2025 - MLB

San Francisco Giants
3 :  2
Kansas City Royals

May 19, 2025 - MLB

San Francisco Giants
1 :  3
Kansas City Royals

May 17, 2025 - MLB

San Francisco Giants
1 :  0
Athletics

May 16, 2025 - MLB

San Francisco Giants
9 :  1
Athletics

May 3, 2025 - MLB

San Francisco Giants
6 :  3
Colorado Rockies
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 27, 2025 - MLB

Detroit Tigers
3 :  1
San Francisco Giants

May 26, 2025 - MLB

Detroit Tigers
3 :  1
San Francisco Giants

May 25, 2025 - MLB

Washington Nationals
2 :  3
San Francisco Giants

May 24, 2025 - MLB

Washington Nationals
3 :  0
San Francisco Giants

May 11, 2025 - MLB

Minnesota Twins
7 :  6
San Francisco Giants

May 9, 2025 - MLB

Minnesota Twins
3 :  1
San Francisco Giants
San Diego Padres
San Diego Padres Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 1, 2025 - MLB

San Diego Padres
6 :  4
Pittsburgh Pirates

May 31, 2025 - MLB

San Diego Padres
0 :  5
Pittsburgh Pirates

May 30, 2025 - MLB

San Diego Padres
3 :  2
Pittsburgh Pirates

May 27, 2025 - MLB

San Diego Padres
8 :  6
Miami Marlins

May 25, 2025 - MLB

Atlanta Braves
3 :  5
San Diego Padres

May 21, 2025 - MLB

Toronto Blue Jays
14 :  0
San Diego Padres
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 1, 2025 - MLB

San Diego Padres
6 :  4
Pittsburgh Pirates

May 31, 2025 - MLB

San Diego Padres
0 :  5
Pittsburgh Pirates

May 30, 2025 - MLB

San Diego Padres
3 :  2
Pittsburgh Pirates

May 27, 2025 - MLB

San Diego Padres
8 :  6
Miami Marlins

May 17, 2025 - MLB

San Diego Padres
1 :  4
Seattle Mariners

May 14, 2025 - MLB

San Diego Padres
5 :  1
Los Angeles Angels
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 25, 2025 - MLB

Atlanta Braves
3 :  5
San Diego Padres

May 21, 2025 - MLB

Toronto Blue Jays
14 :  0
San Diego Padres

May 7, 2025 - MLB

New York Yankees
4 :  3
San Diego Padres

May 6, 2025 - MLB

New York Yankees
12 :  3
San Diego Padres

May 4, 2025 - MLB

Pittsburgh Pirates
0 :  4
San Diego Padres

May 3, 2025 - MLB

Pittsburgh Pirates
1 :  2
San Diego Padres

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

17 %

San Diego Padres

83 %

Apr 30, 2025 - MLB

San Diego Padres
5 :  3
San Francisco Giants

Apr 29, 2025 - MLB

San Diego Padres
7 :  4
San Francisco Giants

Sep 15, 2024 - MLB

San Francisco Giants
3 :  4
San Diego Padres

Sep 8, 2024 - MLB

San Diego Padres
6 :  7
San Francisco Giants

Sep 6, 2024 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Apr 6, 2024 - MLB

San Francisco Giants
0 :  4
San Diego Padres

San Francisco Giants - San Diego Padres Key Points

  1. Giants pitching allows the fewest home runs in MLB
  2. Padres pitching BAA 5th best in MLB
  3. Padres won 8 of last 10 games against Giants
  4. Giants 16-9 record as betting favorites playing at Oracle Park

Our San Francisco Giants vs San Diego Padres Prediction

Cease didn't have a single outing in May where he didn't allow 2 runs or fewer; when he pitched against the Blue Jays in Toronto, he allowed 2 HRs. However, he did exceptionally well the last time he faced the Giants when he struck out 10, although that was in 2024. Ray and Cease, while neither is particularly dominant, if they are great strikeout pitchers and prove it again in 2025, it could be a low-run game. Our prediction for Padres vs Giants is: Under 7.5 runs.

Prediction:

 

Under 7.5

-125
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San Francisco Giants vs San Diego Padres Picks