Philadelphia Phillies vs San Diego Padres Prediction & Picks - MLB

Prediction published on 6/4/26, 4:31 AM  by Lou Aguila in MLB Picks

The Philadelphia Phillies and the San Diego Padres have averaged a combined 5.7 runs per game over their last three meetings. The over/under for Game 3 is set at 8.0 runs.

Momentum: The Philadelphia Phillies (32-29) have won 3 of their last four games, including a pair of 3-2 wins over San Diego in Games 1 and 2. The Padres (32-29) have lost their last four games and gone 1-4 in their current road schedule.

The Matchup: The Phillies have won the last six meetings with the Padres. However, they only managed to win by two runs or more four times.

Starting Pitchers: Phillies RHP Zack Wheeler (4-1, 2.27 ERA) will go head-to-head with Padres RHP Lucas Giolito (2-0, 4.97 ERA).

Wheeler surrendered 4 earned runs over six innings in a 2-4 loss to the LA Dodgers on May 29. Before his last start, Wheeler delivered back-to-back shutouts against Pittsburgh on May 17 and Cleveland on May 23.

The Padres have gone 5-0 in Giolito’s last 5 starts. However, Giolito surrendered 4 earned runs over 2.2 innings in his last start against Washington on May 29. San Diego came away with a win, 7-5, but the Nationals exposed Giolito in that match.

Key Stats: In their last three meetings, the Phillies and the Padres averaged a combined 5.7 runs per game. Philadelphia produced 3.3 runs per game, while San Diego averaged 2.4 runs per game.