Milwaukee Brewers vs San Diego Padres Prediction & Picks - MLB

Prediction published on 10/3/26, 12:12 PM  by Carlos Zabala in MLB Picks

A clash of titans is expected in the playoff series between the Brewers and Padres, which tips off Saturday at American Family Field. The presence of a pitcher like Misiorowski on the mound, the Cy Young Award favorite, makes Milwaukee the -200 favorite to take the first game of the series.

The Brewers have recently dominated the NL Central, rarely more so than this year, where they broke the franchise record by winning 103 games and finishing with the best record in MLB. The "Brew-Crew" isn't exactly a home run team, but they do get key hits and extra-base hits and run the bases well; they had the best run differential in MLB, and their bullpen had the third-lowest ERA in the regular season.

But it's impossible to underestimate the Padres, who have come alive when it matters most. They won 17 of the last 20 games of the regular season and ended the Cubs' Wild Card Series dreams. The way they won was even more impressive, fueled by electrifying home runs from players like Tatis, Machado, and Bogaerts in Game 1 of the Wild Card Series. In Game 2, Sheets hit a key home run as the crowd chanted his name.