Los Angeles Dodgers vs San Diego Padres Prediction & Picks - MLB

Prediction published on 9/23/26, 6:36 PM  by Edgar Jibran | Modified on 9/24/26 at 4:54 PM in MLB Picks

The last game on Wednesday's MLB schedule will feature the second game of the San Diego Padres’ series at the Los Angeles Dodgers. For this game, the Dodgers could be more relaxed than ever after clinching the NL West Division and getting a 5-game advantage over the Atlanta Braves in the NL standings. However, the Dodgers’ ambition was already proven in the first game of this series, when they obliterated the Padres (7-0).

In this regard, the Dodgers are expected to show similar potential in the second game, especially when they will have a positive handicap due to Yoshinobu Yamamoto's start. With such a stellar opening lineup, UNIQLO Field is expected to deliver an amazing atmosphere, as the Dodgers’ crowd is convinced this team has the credentials to contend for a back-to-back World Series title.

Meanwhile, the San Diego Padres must show significant improvement to avoid any surprises from the Arizona D’Backs, who still have little chance of taking the Padres down from the NL Wild Card spots. With this in mind, choosing Robbie Ray to start this game looks like a wise decision, as he has been one of the top pitching performers on the roster throughout the regular season.