Los Angeles Angels vs San Diego Padres Prediction & Picks - MLB
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by Lou Aguila | in MLB Picks
After their 8-0 win in Game 1, the Los Angeles Angels will again attempt to outgun the San Diego Padres in Game 2 of their series. The Angels average roughly 8.0 runs per game, while the Padres average 5.0 runs. The over is set at a manageable over/under 9.5 runs.
Momentum: The San Diego Padres’ 8-game winning run came to an end in Friday’s 0-8 loss to the LA Angels in Game 1. San Diego remains the No.2 team in the NL West with a 13-7 record behind the LA Dodgers (15-4). Meanwhile, the Angels bumped up their record to .500 at 11-10 after winning 3 of their last four games.
The Matchup: The Padres and the Angels are slated for this three-game series this season. The Angels took Game 1 behind another sensational start by Jose Soriano, who threw 5.2 scoreless innings and struck out 8 batters.
The Starters: Padres RHP German Marquez (2-1, 5.54 ERA) will take on Angels LHP Yusei Kikuchi (0-2, 7.50 ERA).
Hot on the Board: The Padres and the Angels are both listed at -110 moneyline. The Padres carry a value of +143 if they can win by at least two runs over the Angels. The total is pegged at over/under 9.5 runs.
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Los Angeles Angels vs San Diego Padres Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
9
|
0.52 | 75 | 39 | 36 |
|
29
|
0.39 | 77 | 30 | 47 |
Los Angeles Angels and San Diego Padres Latest Matches
4/6 (67%)
2/6 (33%)
Apr 17, 2026 - MLB
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
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Apr 12, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 17, 2026 - MLB
Apr 8, 2026 - MLB
Apr 7, 2026 - MLB
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Apr 4, 2026 - MLB
3/6 (50%)
3/6 (50%)
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 13, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
5/6 (83%)
1/6 (17%)
Apr 17, 2026 - MLB
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
6/6 (100%)
0/6 (0%)
Apr 16, 2026 - MLB
Apr 15, 2026 - MLB
Apr 14, 2026 - MLB
Apr 12, 2026 - MLB
Apr 11, 2026 - MLB
Apr 10, 2026 - MLB
4/6 (67%)
2/6 (33%)
Apr 17, 2026 - MLB
Apr 8, 2026 - MLB
Apr 7, 2026 - MLB
Apr 6, 2026 - MLB
Apr 5, 2026 - MLB
Apr 4, 2026 - MLB
Los Angeles Angels against San Diego Padres : Head to Head (H2H)
33 %
67 %
Apr 17, 2026 - MLB
Mar 10, 2026 - MLB Spring Training
Feb 25, 2026 - MLB Spring Training
May 14, 2025 - MLB
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May 12, 2025 - MLB
Los Angeles Angels - San Diego Padres Key Points
- The total has gone OVER in 9 of LA Angels' last 12 games.
- The total has gone OVER in 4 of LA Angels' last 5 games at home.
- The total has gone OVER in 7 of LA Angels' last 8 games against an opponent in the National League.
- The Angels are averaging 8.0 runs per game over their last five matches.
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Our Los Angeles Angels vs San Diego Padres Prediction
Fearless Forecast: The Angels top the Padres again with a 7-5 win
Sharp Play: Total Over 9.5 runs. These are two of the best-scoring teams early this season. Over their last five games, the Padres average 5.0 runs on a .280 BA, whereas the Angels average a staggering 8.2 runs on a .294 BA.
Another reason why we should expect another high-scoring ballgame is that both teams are sending pitchers who are underperforming this season. Angels’ lefty Yusei Kikuchi has already allowed 20 earned runs over 17.2 innings. Padres’ German Marquez surrendered four runs in two of three starts this season, including his last start vs. the Rockies on April 11, in which he gave up three homers in a 5-9 loss.
The total has gone OVER in 4 of LA Angels' last 5 games at home and 9 of LA Angels' last 12 games, a testament to the Angels’ surging offense this year.
Our betting predictions for the San Diego Padres vs. the LA Angels: Total Over 9.5 Runs
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