Houston Astros vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Houston Astros
4/18/25 20:10
San Diego Padres

Prediction:

 

San Diego ML

+130
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 by Travis Pulver | in MLB Picks

It will not be easy to get back on the right side of the scoreboard against a red-hot San Diego Padres team, but the Houston Astros will try in Game One of a three-game home series tonight at Daiken Park in Houston, TX. First pitch is scheduled for 8:10 p.m. EST.

Houston has been struggling to get on track this season; through 18 games, they have yet to win two in a row. The only time they have lost 2+ in a row was a three-game sweep vs. San Francisco. They have one of the lowest team batting averages of the season at .216. But their pitching staff has been one of the best in baseball with a 3.73 ERA (top ten) and 181 strikeouts (fourth best). San Diego, on the other hand, has the best batting average in the league at .274. Their pitching staff has also been top-notch, with a 2.56 ERA and a 1.07 WHIP, while holding opponents to a .193 batting average.

San Diego will turn to Kyle Hart to start the game on the mound for the Padres. In three starts, he’s gone 2-0 with a 5.40 ERA and 1.11 WHIP. Ryan Gusto will get the start for Houston. He appears to be more of an opener, having gone just 2, 2, 3,1, and 4 innings in five starts.

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Houston Astros vs San Diego Padres Form

Table

Teams Pts P W L
7 San Diego Padres
0.556 162 90 72
12 Houston Astros
0.537 162 87 75

Houston Astros and San Diego Padres Latest Matches

Houston Astros
Houston Astros Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

St. Louis Cardinals
4 :  1
Houston Astros

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 13, 2025 - MLB

Houston Astros
7 :  3
Los Angeles Angels

Apr 12, 2025 - MLB

Houston Astros
1 :  4
Los Angeles Angels

Apr 11, 2025 - MLB

Houston Astros
14 :  3
Los Angeles Angels
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 13, 2025 - MLB

Houston Astros
7 :  3
Los Angeles Angels

Apr 12, 2025 - MLB

Houston Astros
1 :  4
Los Angeles Angels

Apr 11, 2025 - MLB

Houston Astros
14 :  3
Los Angeles Angels

Apr 2, 2025 - MLB

Houston Astros
3 :  6
San Francisco Giants

Apr 1, 2025 - MLB

Houston Astros
1 :  3
San Francisco Giants

Mar 31, 2025 - MLB

Houston Astros
2 :  7
San Francisco Giants
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 16, 2025 - MLB

St. Louis Cardinals
4 :  1
Houston Astros

Apr 15, 2025 - MLB

St. Louis Cardinals
0 :  2
Houston Astros

Apr 14, 2025 - MLB

St. Louis Cardinals
8 :  3
Houston Astros

Apr 9, 2025 - MLB

Seattle Mariners
7 :  6
Houston Astros

Apr 8, 2025 - MLB

Seattle Mariners
1 :  2
Houston Astros

Apr 7, 2025 - MLB

Seattle Mariners
4 :  3
Houston Astros
San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 16, 2025 - MLB

San Diego Padres
4 :  2
Chicago Cubs

Apr 14, 2025 - MLB

San Diego Padres
10 :  4
Chicago Cubs

Apr 13, 2025 - MLB

San Diego Padres
6 :  0
Colorado Rockies

Apr 12, 2025 - MLB

San Diego Padres
2 :  0
Colorado Rockies

Apr 11, 2025 - MLB

San Diego Padres
8 :  0
Colorado Rockies

Apr 9, 2025 - MLB

Athletics
1 :  2
San Diego Padres
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 16, 2025 - MLB

San Diego Padres
4 :  2
Chicago Cubs

Apr 14, 2025 - MLB

San Diego Padres
10 :  4
Chicago Cubs

Apr 13, 2025 - MLB

San Diego Padres
6 :  0
Colorado Rockies

Apr 12, 2025 - MLB

San Diego Padres
2 :  0
Colorado Rockies

Apr 11, 2025 - MLB

San Diego Padres
8 :  0
Colorado Rockies

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 9, 2025 - MLB

Athletics
1 :  2
San Diego Padres

Apr 8, 2025 - MLB

Athletics
10 :  4
San Diego Padres

Apr 7, 2025 - MLB

Athletics
4 :  5
San Diego Padres

Apr 5, 2025 - MLB

Chicago Cubs
7 :  1
San Diego Padres

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

Oct 11, 2024 - MLB

Los Angeles Dodgers
2 :  0
San Diego Padres

Houston Astros against San Diego Padres : Head to Head (H2H)

Houston Astros

25 %

San Diego Padres

75 %

Sep 18, 2024 - MLB

San Diego Padres
4 :  0
Houston Astros

Sep 17, 2024 - MLB

San Diego Padres
3 :  4
Houston Astros

Sep 16, 2024 - MLB

San Diego Padres
3 :  1
Houston Astros

Sep 4, 2021 - MLB

San Diego Padres
10 :  2
Houston Astros

Houston Astros - San Diego Padres Key Points

  1. Houston leads the all-time series vs. San Diego 320-296.
  2. The Padres have gone 10-5 vs. the Astros over the last four seasons.
  3. This will be the first time either pitcher has faced the opposing team.
  4. Houston has lost 14 of their last 15 games following a road loss.
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Our Houston Astros vs San Diego Padres Prediction

If the pattern holds, Houston is due for a win, but they are facing a decent pitcher against a potent lineup. Tack on the suspect production coming from their lineup and it becomes a lot harder to justify getting behind the Astros. However, if this is a bullpen game for Houston, the ‘pen’s ERA is 2.94, and they have been playing better at home….

Our Astros vs. Padres Pick: San Diego ML

Prediction:

 

San Diego ML

+130
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Houston Astros vs San Diego Padres Picks