Detroit Tigers vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Detroit Tigers
4/21/25 18:40
San Diego Padres

Prediction:

 

Tigers -1.5 Runs

+154
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 by Lou Aguila | in MLB Picks

The Detroit Tigers look to sustain their momentum as they kick off a new series with the skidding San Diego Padres starting on Monday at Comerica Park.

The Tigers took 3 out of 4 in the series with the Kansas City Royals to improve their record to 13-9, No.1 in the American League Central. They may have lost the series finale 3-4 in extra innings, but that won’t diminish a successful weekend for Detroit, who has just lowered their team ERA to 3.12.

The Padres won Game 3 vs. the Houston Astros, 3-2, on Sunday, but losing three of their last five games has brought down their record to 16-6, 0.5 games ahead of the LA Dodgers (16-5) in the National League West. San Diego is still lethal batting team, averaging .276 with 97 runs this season. They still own the second-best ERA in baseball at 2.74 despite their recent hiccups but they better bring their A-game against the Tigers, who also possess the depth to match their firepower on the mound.

Detroit Tigers vs San Diego Padres Form

Table

Teams Pts P W L
7 San Diego Padres
0.556 162 90 72
11 Detroit Tigers
0.537 162 87 75

Detroit Tigers and San Diego Padres Latest Matches

Detroit Tigers
Detroit Tigers Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2025 - MLB

Detroit Tigers
3 :  4
Kansas City Royals

Apr 19, 2025 - MLB

Detroit Tigers
3 :  1
Kansas City Royals

Apr 18, 2025 - MLB

Detroit Tigers
7 :  3
Kansas City Royals

Apr 17, 2025 - MLB

Detroit Tigers
6 :  1
Kansas City Royals

Apr 16, 2025 - MLB

Milwaukee Brewers
5 :  1
Detroit Tigers

Apr 15, 2025 - MLB

Milwaukee Brewers
5 :  0
Detroit Tigers
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2025 - MLB

Detroit Tigers
3 :  4
Kansas City Royals

Apr 19, 2025 - MLB

Detroit Tigers
3 :  1
Kansas City Royals

Apr 18, 2025 - MLB

Detroit Tigers
7 :  3
Kansas City Royals

Apr 17, 2025 - MLB

Detroit Tigers
6 :  1
Kansas City Royals

Apr 9, 2025 - MLB

Detroit Tigers
3 :  4
New York Yankees

Apr 8, 2025 - MLB

Detroit Tigers
5 :  0
New York Yankees
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 16, 2025 - MLB

Milwaukee Brewers
5 :  1
Detroit Tigers

Apr 15, 2025 - MLB

Milwaukee Brewers
5 :  0
Detroit Tigers

Apr 14, 2025 - MLB

Milwaukee Brewers
1 :  9
Detroit Tigers

Apr 13, 2025 - MLB

Minnesota Twins
5 :  1
Detroit Tigers

Apr 12, 2025 - MLB

Minnesota Twins
0 :  4
Detroit Tigers

Apr 11, 2025 - MLB

Minnesota Twins
6 :  7
Detroit Tigers
San Diego Padres
San Diego Padres Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 19, 2025 - MLB

Houston Astros
3 :  2
San Diego Padres

Apr 18, 2025 - MLB

Houston Astros
6 :  4
San Diego Padres

Apr 16, 2025 - MLB

San Diego Padres
4 :  2
Chicago Cubs

Apr 14, 2025 - MLB

San Diego Padres
10 :  4
Chicago Cubs

Apr 13, 2025 - MLB

San Diego Padres
6 :  0
Colorado Rockies

Apr 12, 2025 - MLB

San Diego Padres
2 :  0
Colorado Rockies
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 16, 2025 - MLB

San Diego Padres
4 :  2
Chicago Cubs

Apr 14, 2025 - MLB

San Diego Padres
10 :  4
Chicago Cubs

Apr 13, 2025 - MLB

San Diego Padres
6 :  0
Colorado Rockies

Apr 12, 2025 - MLB

San Diego Padres
2 :  0
Colorado Rockies

Apr 11, 2025 - MLB

San Diego Padres
8 :  0
Colorado Rockies

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 19, 2025 - MLB

Houston Astros
3 :  2
San Diego Padres

Apr 18, 2025 - MLB

Houston Astros
6 :  4
San Diego Padres

Apr 9, 2025 - MLB

Athletics
1 :  2
San Diego Padres

Apr 8, 2025 - MLB

Athletics
10 :  4
San Diego Padres

Apr 7, 2025 - MLB

Athletics
4 :  5
San Diego Padres

Apr 5, 2025 - MLB

Chicago Cubs
7 :  1
San Diego Padres

Detroit Tigers against San Diego Padres : Head to Head (H2H)

Detroit Tigers

33 %

San Diego Padres

67 %

Sep 5, 2024 - MLB

San Diego Padres
3 :  4
Detroit Tigers

Sep 4, 2024 - MLB

San Diego Padres
6 :  5
Detroit Tigers

Sep 2, 2024 - MLB

San Diego Padres
3 :  0
Detroit Tigers

Detroit Tigers - San Diego Padres Key Points

  1. San Diego is 14-6 SU in its last 20 games.
  2. San Diego is 3-6 SU in its last 9 games when playing on the road against Detroit.
  3. Detroit is 11-5 SU in its last 16 games.
  4. Detroit is 8-2 SU in its last 10 games at home.

Our Detroit Tigers vs San Diego Padres Prediction

Fearless Forecast: The Tigers continue to roll at home, downing the Padres with their energized offense

I would pick the Tigers to stay cooking at Comerica Park. Not only are they 8-2 against the spread in their last 10 home games, but Detroit is putting in a better batting average in their last five games than San Diego did in their last five. The Tigers are averaging 4.2 runs, whereas the Padres are struggling with 2.8 runs per game in their 5-game stretch. Keider Montero had a horrific stint vs. the Brewers, allowing five earned runs in 5.0 innings. But I am still optimistic that he can regain his mojo against the struggling Padres’ batters in Game 1. Padres’ starter Randy Vasquez has been nice this season with a 1-1 record and 1.74 ERA, but there’s a good chance he will get an L again not because he’s bad but the Padres’ offense is on a slump right now that they just can’t get him enough runs to beat another playoff-caliber team. Our betting prediction for Detroit Tigers vs. San Diego Padres: Tigers -1.5 Runs.

Prediction:

 

Tigers -1.5 Runs

+154
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Detroit Tigers vs San Diego Padres Picks