Colorado Rockies vs San Diego Padres Prediction & Picks - MLB

Prediction published on 4/22/26, 5:05 PM  by Carlos Zabala | Modified on 4/23/26 at 12:00 AM in MLB Picks

It's rare for a game at the altitude of Coors Field to end 1-0. In the series opener in Colorado, San Diego gave the Rockies their 15th loss of the season. Meanwhile, they themselves added their 16th loss, preventing the Dodgers from pulling away too quickly in the NL West.

The Padres' pitching is elite. But it's even better when perhaps the best bullpen in MLB takes over a game led by a starter like Randy Vásquez. He dominated Colorado's offense for seven innings, displaying absolute control and issuing no walks. Jason Adam then took over, doing his usual flawless job as setup man, and on Tuesday, the ninth inning wasn't given to the flamethrower closer Miller. Instead, Morejón came in to earn his first save of 2026. The only run came on a bases-loaded walk when Machado drew one.

The Padres had already swept the Rockies at Petco Park. After the decent hitting they produced in Colorado in the 2-2 split series against the Dodgers, it was concerning that only the top three hitters got hits on Tuesday; the rest of the lineup went 0-for-17.