Colorado Rockies vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Colorado Rockies
4/21/26 20:40
San Diego Padres

Prediction:

 

San Diego to win

-140
$350 offered for betting!

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 by Bill Christy | in MLB Picks

The NL West will feature its 2nd series battle between the San Diego Padres (15-7) and the Colorado Rockies (9-44) of the month, beginning tonight in Colorado. The Padres took care of business in the previous 4-game series by sweeping the Rockies in San Diego just over 10 days ago.

Since the previous series with the Rockies, San Diego has stayed hot and swept the Mariners before taking 2 of 3 against the Angels in their latest series. This San Diego squad has been outscoring their opponents by an average of 2.2 runs per game. Outside of a hiccup in game one against the Angels, the Padres have been perfect in their last 11 games.

After getting swept by these Padres, the Rockies have looked better lately. They did lose 2 of 3 to the Astros, but were able to split their 4-game series with the defending champion Dodgers. While the Rockies have played better, they will have a tough time against Randy Vasquez.

While he is coming off a shaky start against the Mariners in his last game, he is still holding a 2.49 ERA and held these Rockies to just 1 run in 7 innings in their last meeting.

Colorado Rockies vs San Diego Padres Form

Table

Teams Pts P W L
8 San Diego Padres
0.531 81 43 38
30 Colorado Rockies
0.398 83 33 50

Colorado Rockies and San Diego Padres Latest Matches

Colorado Rockies
Colorado Rockies Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 20, 2026 - MLB

Colorado Rockies
3 :  12
Los Angeles Dodgers

Apr 19, 2026 - MLB

Colorado Rockies
9 :  6
Los Angeles Dodgers

Apr 18, 2026 - MLB

Colorado Rockies
4 :  3
Los Angeles Dodgers

Apr 17, 2026 - MLB

Colorado Rockies
1 :  7
Los Angeles Dodgers

Apr 16, 2026 - MLB

Houston Astros
2 :  3
Colorado Rockies

Apr 15, 2026 - MLB

Houston Astros
3 :  1
Colorado Rockies
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2026 - MLB

Colorado Rockies
3 :  12
Los Angeles Dodgers

Apr 19, 2026 - MLB

Colorado Rockies
9 :  6
Los Angeles Dodgers

Apr 18, 2026 - MLB

Colorado Rockies
4 :  3
Los Angeles Dodgers

Apr 17, 2026 - MLB

Colorado Rockies
1 :  7
Los Angeles Dodgers

Apr 8, 2026 - MLB

Colorado Rockies
9 :  1
Houston Astros

Apr 7, 2026 - MLB

Colorado Rockies
5 :  1
Houston Astros
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 16, 2026 - MLB

Houston Astros
2 :  3
Colorado Rockies

Apr 15, 2026 - MLB

Houston Astros
3 :  1
Colorado Rockies

Apr 14, 2026 - MLB

Houston Astros
7 :  6
Colorado Rockies

Apr 12, 2026 - MLB

San Diego Padres
7 :  2
Colorado Rockies

Apr 11, 2026 - MLB

San Diego Padres
9 :  5
Colorado Rockies

Apr 10, 2026 - MLB

San Diego Padres
5 :  2
Colorado Rockies
San Diego Padres
San Diego Padres Latest matches
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 19, 2026 - MLB

Los Angeles Angels
1 :  2
San Diego Padres

Apr 18, 2026 - MLB

Los Angeles Angels
1 :  4
San Diego Padres

Apr 17, 2026 - MLB

Los Angeles Angels
8 :  0
San Diego Padres

Apr 16, 2026 - MLB

San Diego Padres
5 :  2
Seattle Mariners

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 16, 2026 - MLB

San Diego Padres
5 :  2
Seattle Mariners

Apr 15, 2026 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Apr 14, 2026 - MLB

San Diego Padres
4 :  1
Seattle Mariners

Apr 12, 2026 - MLB

San Diego Padres
7 :  2
Colorado Rockies

Apr 11, 2026 - MLB

San Diego Padres
9 :  5
Colorado Rockies

Apr 10, 2026 - MLB

San Diego Padres
5 :  2
Colorado Rockies
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 19, 2026 - MLB

Los Angeles Angels
1 :  2
San Diego Padres

Apr 18, 2026 - MLB

Los Angeles Angels
1 :  4
San Diego Padres

Apr 17, 2026 - MLB

Los Angeles Angels
8 :  0
San Diego Padres

Apr 8, 2026 - MLB

Pittsburgh Pirates
2 :  8
San Diego Padres

Apr 7, 2026 - MLB

Pittsburgh Pirates
7 :  1
San Diego Padres

Apr 6, 2026 - MLB

Pittsburgh Pirates
0 :  5
San Diego Padres

Colorado Rockies against San Diego Padres : Head to Head (H2H)

Colorado Rockies

33 %

San Diego Padres

67 %

Apr 12, 2026 - MLB

San Diego Padres
7 :  2
Colorado Rockies

Apr 11, 2026 - MLB

San Diego Padres
9 :  5
Colorado Rockies

Apr 10, 2026 - MLB

San Diego Padres
5 :  2
Colorado Rockies

Apr 9, 2026 - MLB

San Diego Padres
7 :  3
Colorado Rockies

Mar 20, 2026 - MLB Spring Training

San Diego Padres
3 :  9
Colorado Rockies

Feb 27, 2026 - MLB Spring Training

Colorado Rockies
3 :  2
San Diego Padres

Colorado Rockies - San Diego Padres Key Points

  1. San Diego is 10-1 SU in its last 11 games.
  2. San Diego is 8-0 SU in its last 8 games when playing as the favorite.
  3. Colorado is 4-21 SU in its last 25 games against an opponent in the National League West Division.
  4. Colorado is 3-14 SU in its last 17 games against San Diego.

Our Colorado Rockies vs San Diego Padres Prediction

This Padres team looks to be in midseason form already. They should be uber confident heading into this series in Colorado. We believe that Vasquez will put his last start behind him and get back to the form we saw when he last faced Colorado. They may not sweep the Rockies again, but we expect them to at least take game one tonight.

Our prediction for Colorado Rockies vs San Diego Padres: San Diego to win

Prediction:

 

San Diego to win

-140
$350 offered for betting!

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Colorado Rockies vs San Diego Padres Picks