Cleveland Guardians vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
8/16/26 13:40
San Diego Padres

Prediction:

 

San Diego to win

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 by Bill Christy | in MLB Picks

The San Diego Padres and Cleveland Guardians will play the 3rd and final game of their series in Cleveland this afternoon. It will decide the series, as each team took one of the 1st two games.

The bats were hot for both teams in the 1st game of this series. Four different batters for the Padres had multi-hit games, while Tatis Jr and Bogaerts each made the most of their only hits by putting the ball out of the park. Lowe and Rocchio of the Guardians combined to go 5-8 with 2 home runs, 2 doubles, and 3 RBIs. After the Guardians took an early 3-0 lead through the 1st three innings, the Padres came back and ultimately won 7-5 with Bradgley Rodriguez picking up his 1st save of the season.

Joey Cantillo, the starter for the Guardians, was the story in game two. He went 6 strong innings, where he allowed just 1 run on 1 hit and struck out 7 Padres. Kwan, Ramirez, and Adell combined to go 5-12 with 4 doubles and 3 RBIs to give Cantillo all the run support he needed to pick up the win for the Guardians.

Newly acquired Casey Mize will make his 3rd start for the Padres in this one and will be countered by Tanner Bibee of the Guardians. Bibee has pitched decently on the season with a sub-4.00 ERA but has not gotten enough run support. He is just 4-12 on the season and can not seem to find his way to that 5th win.

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Cleveland Guardians vs San Diego Padres Form

Table

Teams Pts P W L
6 San Diego Padres
0.562 162 91 71
11 Cleveland Guardians
0.525 162 85 77

Cleveland Guardians and San Diego Padres Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 15, 2026 - MLB

Cleveland Guardians
6 :  1
San Diego Padres

Aug 14, 2026 - MLB

Cleveland Guardians
5 :  7
San Diego Padres

Aug 13, 2026 - MLB

Detroit Tigers
3 :  0
Cleveland Guardians

Aug 12, 2026 - MLB

Detroit Tigers
4 :  6
Cleveland Guardians

Aug 11, 2026 - MLB

Detroit Tigers
6 :  4
Cleveland Guardians

Aug 9, 2026 - MLB

Chicago White Sox
5 :  3
Cleveland Guardians
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 15, 2026 - MLB

Cleveland Guardians
6 :  1
San Diego Padres

Aug 14, 2026 - MLB

Cleveland Guardians
5 :  7
San Diego Padres

Aug 6, 2026 - MLB

Cleveland Guardians
6 :  13
New York Mets

Aug 5, 2026 - MLB

Cleveland Guardians
5 :  6
New York Mets

Aug 4, 2026 - MLB

Cleveland Guardians
2 :  6
New York Mets

Aug 2, 2026 - MLB

Cleveland Guardians
5 :  0
Arizona Diamondbacks
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 13, 2026 - MLB

Detroit Tigers
3 :  0
Cleveland Guardians

Aug 12, 2026 - MLB

Detroit Tigers
4 :  6
Cleveland Guardians

Aug 11, 2026 - MLB

Detroit Tigers
6 :  4
Cleveland Guardians

Aug 9, 2026 - MLB

Chicago White Sox
5 :  3
Cleveland Guardians

Aug 8, 2026 - MLB

Chicago White Sox
6 :  3
Cleveland Guardians

Aug 7, 2026 - MLB

Chicago White Sox
2 :  8
Cleveland Guardians
San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 15, 2026 - MLB

Cleveland Guardians
6 :  1
San Diego Padres

Aug 14, 2026 - MLB

Cleveland Guardians
5 :  7
San Diego Padres

Aug 12, 2026 - MLB

San Diego Padres
4 :  3
Milwaukee Brewers

Aug 11, 2026 - MLB

San Diego Padres
11 :  2
Milwaukee Brewers

Aug 10, 2026 - MLB

San Diego Padres
3 :  2
Milwaukee Brewers

Aug 9, 2026 - MLB

San Diego Padres
7 :  2
Houston Astros
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 12, 2026 - MLB

San Diego Padres
4 :  3
Milwaukee Brewers

Aug 11, 2026 - MLB

San Diego Padres
11 :  2
Milwaukee Brewers

Aug 10, 2026 - MLB

San Diego Padres
3 :  2
Milwaukee Brewers

Aug 9, 2026 - MLB

San Diego Padres
7 :  2
Houston Astros

Aug 8, 2026 - MLB

San Diego Padres
3 :  2
Houston Astros

Aug 7, 2026 - MLB

San Diego Padres
3 :  6
Houston Astros
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 15, 2026 - MLB

Cleveland Guardians
6 :  1
San Diego Padres

Aug 14, 2026 - MLB

Cleveland Guardians
5 :  7
San Diego Padres

Aug 6, 2026 - MLB

Arizona Diamondbacks
1 :  5
San Diego Padres

Aug 5, 2026 - MLB

Arizona Diamondbacks
10 :  4
San Diego Padres

Aug 4, 2026 - MLB

Arizona Diamondbacks
4 :  9
San Diego Padres

Aug 3, 2026 - MLB

Arizona Diamondbacks
5 :  1
San Diego Padres

Cleveland Guardians against San Diego Padres : Head to Head (H2H)

Cleveland Guardians

33 %

San Diego Padres

67 %

Aug 15, 2026 - MLB

Cleveland Guardians
6 :  1
San Diego Padres

Aug 14, 2026 - MLB

Cleveland Guardians
5 :  7
San Diego Padres

Mar 14, 2026 - MLB Spring Training

San Diego Padres
8 :  5
Cleveland Guardians

Mar 7, 2026 - MLB Spring Training

Cleveland Guardians
7 :  1
San Diego Padres

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians

Apr 1, 2025 - MLB

San Diego Padres
7 :  0
Cleveland Guardians
Cleveland Guardians vs San Diego Padres Picks

Cleveland Guardians - San Diego Padres Key Points

  1. Padres are 4-0 in their last 4 interleague games vs. a team with a winning record.
  2. Padres are 6-1 in their last 7 games,
  3. Guardians are 4-9 this month.
  4. Guardians are 2-5 in their last 7 games.

Our Cleveland Guardians vs San Diego Padres Prediction

Tanner Bibee has had some seriously bad luck this season. We do not think that will change here against the visiting Padres. Casey Mize was rocked in his initial start for the Padres but looked much better in his 2nd outing where he allowed 2 runs in 6 innings. Now he faces a Guardians lineup that is near the bottom of the league in all offensive categories. We expect him to look even better today and help these Padres to the road win.

Our prediction for Cleveland Guardians vs San Diego Padres: San Diego to win

Prediction:

 

San Diego to win

−110
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