Chicago Cubs vs San Diego Padres Prediction & Picks - MLB
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by Lou Aguila in MLB Picks
Holding a 4-2 record in their last 6 games against the San Diego Padres, the Chicago Cubs will deploy left-handed pitcher Shoto Imanaga to contain the NL West powerhouse in Game 1 of their series.
Imanaga has won his last three starts against the Padres.
Current Form:
The Chicago Cubs have won six of their last seven games, including the last two games of their series against the Milwaukee Brewers. The Cubs improved to 46-38, trailing the Brewers by 5.5 games.
After winning Game 1 over the LA Dodgers 7-1, the San Diego Padres dropped their last two games against the defending World Series champions. At 43-39, the Padres are now 10 games behind the 54-30 Dodgers in the NL West standings.
Starting Pitchers:
Cubs LHP Shoto Imanaga (5-6, 4.40 ERA) surrendered 4 earned runs over 5.1 innings in a 10-5 win over the Mets on June 24. Imanaga has posted a 5.27 ERA over his last five starts.
Padres RHP Griffin Canning (1-5, 7.38 ERA) also gave up 4 earned runs but in 0.2 innings in a 7-6 F/10 win over the Braves.
The Matchup: The Cubs have won 4 of their last 6 games against the Padres.
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Chicago Cubs vs San Diego Padres Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
7
|
0.548 | 84 | 46 | 38 |
|
9
|
0.524 | 82 | 43 | 39 |
Chicago Cubs and San Diego Padres Latest Matches
5/6 (83%)
1/6 (17%)
Jun 28, 2026 - MLB
Jun 27, 2026 - MLB
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Jun 24, 2026 - MLB
3/6 (50%)
3/6 (50%)
Jun 20, 2026 - MLB
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Jun 7, 2026 - MLB
5/6 (83%)
1/6 (17%)
Jun 28, 2026 - MLB
Jun 27, 2026 - MLB
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Jun 24, 2026 - MLB
4/6 (67%)
2/6 (33%)
Jun 28, 2026 - MLB
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4/6 (67%)
2/6 (33%)
Jun 28, 2026 - MLB
Jun 27, 2026 - MLB
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Jun 24, 2026 - MLB
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Jun 22, 2026 - MLB
2/6 (33%)
4/6 (67%)
Jun 21, 2026 - MLB
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Jun 15, 2026 - MLB
Chicago Cubs against San Diego Padres : Head to Head (H2H)
67 %
33 %
Apr 29, 2026 - MLB
Apr 28, 2026 - MLB
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Mar 6, 2026 - MLB Spring Training
Feb 24, 2026 - MLB Spring Training
Oct 2, 2025 - MLB
Chicago Cubs - San Diego Padres Key Points
- Chicago Cubs is 7-1 SU in its last 8 games against an opponent in the National League.
- Chicago Cubs is 6-1 SU in its last 7 games.
- San Diego is 2-4 SU in its last 6 games against Chicago Cubs.
- San Diego is 4-10 SU in its last 14 games on the road.
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Our Chicago Cubs vs San Diego Padres Prediction
The Cubs come away with a win over the Padres in Game 1.
Chicago is coming into the fresh series with the Padres brimming with confidence after beating the Brewers in 2 out of 3 games.
Both teams are averaging over 5.0 runs per game over the last five games, but the Cubs have continued to churn out elite numbers on the mound.
Chicago has pitched to a 3.52 ERA over their last five assignments. As for the Padres, they have posted a 4.70 ERA, with their bullpen registering a 5.20 ERA in their last five games.
Cubs starter Shota Imanaga has also won his last three starts against the Padres. Imanaga, who has not conceded more than two runs in any of his starts against the Padres, blanked the Padres through five innings in his last outing against the team on April 15, 2025.
There’s a good chance Imanaga will deliver another quality start against the Padres, considering that San Diego is only averaging 2.8 runs per game against left-handed pitchers this season.
Moreover, the Padres have been dreadful on the road this month. They are 4-10 in their last 14 games away from home. On the other hand, the Cubs hold a 7-1 record in their last 8 games against an opponent in the National League.
Our betting prediction for the San Diego Padres vs. the Chicago Cubs: The Cubs will wn
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