Chicago Cubs vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Chicago Cubs
9/30/25 15:08
San Diego Padres

Prediction:

 

Chicago Cubs win the match

−116
$200 offered for betting!

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 by Tyler Doty | in MLB Picks

The Major League Baseball playoffs are underway, and the first game will be played at Wrigley Field, with the Chicago Cubs taking on the San Diego Padres.

 This stage is also known as the Wild Card Series, which is a best-of-three series, with the winner advancing to the Division Series of their respective league. 

The Cubs finished second in the National League Central Division with 92 wins and 70 losses, giving them a 56% winning percentage and a 5.0 percentage point lead over the Brewers, who advanced directly.  

Meanwhile, the San Diego Padres finished second in the National League West Division with 90 wins and 72 losses, giving them a 55% winning percentage. They also have a 3.0 percentage point lead over the Dodgers.

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Chicago Cubs vs San Diego Padres Form

Chicago Cubs and San Diego Padres Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 23, 2025 - MLB

Chicago Cubs
7 :  9
New York Mets

Sep 17, 2025 - MLB

Pittsburgh Pirates
4 :  8
Chicago Cubs

Sep 16, 2025 - MLB

Pittsburgh Pirates
1 :  4
Chicago Cubs

Sep 15, 2025 - MLB

Pittsburgh Pirates
0 :  4
Chicago Cubs

Sep 9, 2025 - MLB

Atlanta Braves
1 :  6
Chicago Cubs

Sep 8, 2025 - MLB

Atlanta Braves
4 :  1
Chicago Cubs
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 23, 2025 - MLB

Chicago Cubs
7 :  9
New York Mets

Sep 3, 2025 - MLB

Chicago Cubs
1 :  5
Atlanta Braves

Aug 21, 2025 - MLB

Chicago Cubs
1 :  4
Milwaukee Brewers

Aug 20, 2025 - MLB

Chicago Cubs
4 :  3
Milwaukee Brewers

Aug 19, 2025 - MLB

Chicago Cubs
4 :  1
Milwaukee Brewers

Aug 19, 2025 - MLB

Chicago Cubs
6 :  4
Milwaukee Brewers
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 17, 2025 - MLB

Pittsburgh Pirates
4 :  8
Chicago Cubs

Sep 16, 2025 - MLB

Pittsburgh Pirates
1 :  4
Chicago Cubs

Sep 15, 2025 - MLB

Pittsburgh Pirates
0 :  4
Chicago Cubs

Sep 9, 2025 - MLB

Atlanta Braves
1 :  6
Chicago Cubs

Sep 8, 2025 - MLB

Atlanta Braves
4 :  1
Chicago Cubs

Aug 30, 2025 - MLB

Colorado Rockies
3 :  4
Chicago Cubs
San Diego Padres
San Diego Padres Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 24, 2025 - MLB

San Diego Padres
1 :  3
Milwaukee Brewers

Sep 23, 2025 - MLB

San Diego Padres
7 :  0
Milwaukee Brewers

Sep 22, 2025 - MLB

San Diego Padres
5 :  4
Milwaukee Brewers

Sep 18, 2025 - MLB

New York Mets
6 :  1
San Diego Padres

Sep 17, 2025 - MLB

New York Mets
4 :  7
San Diego Padres

Sep 16, 2025 - MLB

New York Mets
8 :  3
San Diego Padres
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 24, 2025 - MLB

San Diego Padres
1 :  3
Milwaukee Brewers

Sep 23, 2025 - MLB

San Diego Padres
7 :  0
Milwaukee Brewers

Sep 22, 2025 - MLB

San Diego Padres
5 :  4
Milwaukee Brewers

Sep 12, 2025 - MLB

San Diego Padres
2 :  4
Colorado Rockies

Sep 11, 2025 - MLB

San Diego Padres
2 :  0
Colorado Rockies

Sep 9, 2025 - MLB

San Diego Padres
2 :  4
Cincinnati Reds
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 18, 2025 - MLB

New York Mets
6 :  1
San Diego Padres

Sep 17, 2025 - MLB

New York Mets
4 :  7
San Diego Padres

Sep 16, 2025 - MLB

New York Mets
8 :  3
San Diego Padres

Sep 7, 2025 - MLB

Colorado Rockies
1 :  8
San Diego Padres

Sep 6, 2025 - MLB

Colorado Rockies
8 :  10
San Diego Padres

Sep 5, 2025 - MLB

Colorado Rockies
3 :  0
San Diego Padres

Chicago Cubs against San Diego Padres : Head to Head (H2H)

Chicago Cubs

50 %

San Diego Padres

50 %

Apr 16, 2025 - MLB

San Diego Padres
4 :  2
Chicago Cubs

Apr 14, 2025 - MLB

San Diego Padres
10 :  4
Chicago Cubs

Apr 5, 2025 - MLB

Chicago Cubs
7 :  1
San Diego Padres

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

May 7, 2024 - MLB

Chicago Cubs
3 :  2
San Diego Padres

May 6, 2024 - MLB

Chicago Cubs
3 :  6
San Diego Padres
Chicago Cubs vs San Diego Padres Picks

Chicago Cubs - San Diego Padres Key Points

  1. The Cubs are 4-6 in their last 10.
  2. The Cubs have 50 wins and 31 losses at home.
  3. In their last 10 games, the Padres have seven wins and three losses.
  4. The San Diego Padres have 38 wins and 43 losses on the road.

Our Chicago Cubs vs San Diego Padres Prediction

It is a fact that the Cubs team has long been unable to deliver a resounding victory to their fans in the postseason. Now they have the perfect setting to turn this situation around at home and take the first step toward advancing to the next round.  

Though they aren't in the best run of form, winning just 4 of their last 10 games, the Cubs are a different team at home. We believe they will fully benefit from home-field advantage on this first night of Wild Card games. Furthermore, the Padres are under .500 on the road this season.

Our pick for the Wild Card matchup between the Cubs and the San Diego Padres is: Cubs ML.

Prediction:

 

Chicago Cubs win the match

−116
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.