Chicago Cubs vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Chicago Cubs
4/5/25 14:20
San Diego Padres

Prediction:

 

Chicago Cubs will win

 

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 by Lou Aguila | in MLB Picks

The San Diego Padres look to jump back into the winner’s circle as they gun for revenge against the Chicago Cubs at Wrigley Field on Saturday.

The Padres’ unbeaten run to start the 2025 MLB season ended on Friday after bowing to the Cubs, 1-3. San Diego had no answer to Cubs’ hurler Shoto Imanaga, who conceded one run in eight innings. The Padres, batting .298/.369/.440 with 36 runs this season, will be counting on Nick Pivetta (1-0, 0.00 ERA) to get them back into their winning groove.

The Cubs have won their last four games, including Friday’s big win over the Padres. Chicago banked on their pitching all night, led by Imanaga, to contain the Padres’ high-powered offense. The Cubs hope starter Matthew Boyd can sustain their dominance on the mound in Saturday’s Game 2.

Chicago Cubs vs San Diego Padres Form

Table

Teams Pts P W L
6 Chicago Cubs
0.568 162 92 70
7 San Diego Padres
0.556 162 90 72

Chicago Cubs and San Diego Padres Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

Apr 1, 2025 - MLB

Athletics
4 :  7
Chicago Cubs

Mar 31, 2025 - MLB

Athletics
3 :  18
Chicago Cubs

Mar 30, 2025 - MLB

Arizona Diamondbacks
10 :  6
Chicago Cubs

Mar 29, 2025 - MLB

Arizona Diamondbacks
3 :  4
Chicago Cubs

Mar 28, 2025 - MLB

Arizona Diamondbacks
8 :  1
Chicago Cubs
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

Mar 19, 2025 - MLB

Chicago Cubs
3 :  6
Los Angeles Dodgers

Mar 18, 2025 - MLB

Chicago Cubs
1 :  4
Los Angeles Dodgers

Sep 21, 2024 - MLB

Chicago Cubs
1 :  5
Washington Nationals

Sep 19, 2024 - MLB

Chicago Cubs
7 :  6
Washington Nationals

Sep 8, 2024 - MLB

Chicago Cubs
2 :  1
New York Yankees
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2025 - MLB

Athletics
4 :  7
Chicago Cubs

Mar 31, 2025 - MLB

Athletics
3 :  18
Chicago Cubs

Mar 30, 2025 - MLB

Arizona Diamondbacks
10 :  6
Chicago Cubs

Mar 29, 2025 - MLB

Arizona Diamondbacks
3 :  4
Chicago Cubs

Mar 28, 2025 - MLB

Arizona Diamondbacks
8 :  1
Chicago Cubs

Sep 25, 2024 - MLB

Philadelphia Phillies
9 :  6
Chicago Cubs
San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians

Apr 1, 2025 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Mar 31, 2025 - MLB

San Diego Padres
7 :  2
Cleveland Guardians

Mar 30, 2025 - MLB

San Diego Padres
5 :  0
Atlanta Braves

Mar 29, 2025 - MLB

San Diego Padres
1 :  0
Atlanta Braves
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians

Apr 1, 2025 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Mar 31, 2025 - MLB

San Diego Padres
7 :  2
Cleveland Guardians

Mar 30, 2025 - MLB

San Diego Padres
5 :  0
Atlanta Braves

Mar 29, 2025 - MLB

San Diego Padres
1 :  0
Atlanta Braves

Mar 28, 2025 - MLB

San Diego Padres
4 :  3
Atlanta Braves
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

Oct 11, 2024 - MLB

Los Angeles Dodgers
2 :  0
San Diego Padres

Oct 6, 2024 - MLB

Los Angeles Dodgers
2 :  10
San Diego Padres

Oct 5, 2024 - MLB

Los Angeles Dodgers
7 :  5
San Diego Padres

Sep 28, 2024 - MLB

Arizona Diamondbacks
0 :  5
San Diego Padres

Sep 26, 2024 - MLB

Los Angeles Dodgers
7 :  2
San Diego Padres

Chicago Cubs against San Diego Padres : Head to Head (H2H)

Chicago Cubs

33 %

San Diego Padres

67 %

Apr 4, 2025 - MLB

Chicago Cubs
3 :  1
San Diego Padres

May 7, 2024 - MLB

Chicago Cubs
3 :  2
San Diego Padres

May 6, 2024 - MLB

Chicago Cubs
3 :  6
San Diego Padres

Apr 10, 2024 - MLB

San Diego Padres
10 :  2
Chicago Cubs

Apr 8, 2024 - MLB

San Diego Padres
9 :  8
Chicago Cubs

Mar 4, 2024 - MLB Spring Training

San Diego Padres
2 :  1
Chicago Cubs

Chicago Cubs - San Diego Padres Key Points

  1. Chicago Cubs are 5-1 SU in their last 6 games.
  2. Chicago Cubs are 4-1 SU in their last 5 games played in April.
  3. San Diego are 1-4 SU in their last 5 games on the road.
  4. San Diego are 7-1 SU in their last 8 games.

Our Chicago Cubs vs San Diego Padres Prediction

It won’t be easy to repeat against the Padres, but I believe the Cubs have what it takes to pull it off. Boyd is coming off a strong start by blanking the Arizona Diamondbacks through five innings of a 10-6 loss. However, the key to a Cubs victory would heavily depend on the performance bullpen, who had held a 6.00+ ERA this season before shutting out the Padres in the final two innings of Game 1. Our betting prediction for San Diego Padres vs. Chicago Cubs: Cubs will win.

Prediction:

 

Chicago Cubs will win

 

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago Cubs vs San Diego Padres Picks