Chicago Cubs vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Chicago Cubs
4/4/25 14:20
San Diego Padres

Prediction:

 

Cubs -1.5.

+140
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 by Carlos Zabala in MLB Picks

In Sacramento, the Cubs' bats continued to be hot to start 2025, especially Seiya Susuki, who hit three home runs on April 1 and 2 before the team's debut at Wrigley Field against the undefeated Padres. All in all, since the Tokyo Series, arriving in Chicago with a 5-4 record, including nine road games against the Dodgers and D-backs, is a good record.

The Cubs are third in the MLB in home runs with 14 and seventh in team OBP with 368. However, the team appears to be burdened with the same bullpen issues that marred their 2024 season now in 2025.

Meanwhile, the Padres, unlike the Cubs, will be heading to Petco Park for the first time this season, undefeated and with a lineup whose nearly all members have responded well to start the year. Merill recently finalized his contract extension with the Padres, who secured him a nine-year contract as one of the faces of the franchise. Merill already responded with a .417 AVG to start the season and hit a home run in the final game against the Guardians.

Chicago Cubs vs San Diego Padres Form

Table

Teams Pts P W L
6 Chicago Cubs
0.568 162 92 70
7 San Diego Padres
0.556 162 90 72

Chicago Cubs and San Diego Padres Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2025 - MLB

Athletics
4 :  7
Chicago Cubs

Mar 31, 2025 - MLB

Athletics
3 :  18
Chicago Cubs

Mar 30, 2025 - MLB

Arizona Diamondbacks
10 :  6
Chicago Cubs

Mar 29, 2025 - MLB

Arizona Diamondbacks
3 :  4
Chicago Cubs

Mar 28, 2025 - MLB

Arizona Diamondbacks
8 :  1
Chicago Cubs

Mar 19, 2025 - MLB

Chicago Cubs
3 :  6
Los Angeles Dodgers
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 19, 2025 - MLB

Chicago Cubs
3 :  6
Los Angeles Dodgers

Mar 18, 2025 - MLB

Chicago Cubs
1 :  4
Los Angeles Dodgers

Sep 21, 2024 - MLB

Chicago Cubs
1 :  5
Washington Nationals

Sep 19, 2024 - MLB

Chicago Cubs
7 :  6
Washington Nationals

Sep 8, 2024 - MLB

Chicago Cubs
2 :  1
New York Yankees

Sep 7, 2024 - MLB

Chicago Cubs
0 :  2
New York Yankees
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 1, 2025 - MLB

Athletics
4 :  7
Chicago Cubs

Mar 31, 2025 - MLB

Athletics
3 :  18
Chicago Cubs

Mar 30, 2025 - MLB

Arizona Diamondbacks
10 :  6
Chicago Cubs

Mar 29, 2025 - MLB

Arizona Diamondbacks
3 :  4
Chicago Cubs

Mar 28, 2025 - MLB

Arizona Diamondbacks
8 :  1
Chicago Cubs

Sep 25, 2024 - MLB

Philadelphia Phillies
9 :  6
Chicago Cubs
San Diego Padres
San Diego Padres Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians

Apr 1, 2025 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Mar 31, 2025 - MLB

San Diego Padres
7 :  2
Cleveland Guardians

Mar 30, 2025 - MLB

San Diego Padres
5 :  0
Atlanta Braves

Mar 29, 2025 - MLB

San Diego Padres
1 :  0
Atlanta Braves

Mar 28, 2025 - MLB

San Diego Padres
4 :  3
Atlanta Braves
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Apr 2, 2025 - MLB

San Diego Padres
5 :  2
Cleveland Guardians

Apr 1, 2025 - MLB

San Diego Padres
7 :  0
Cleveland Guardians

Mar 31, 2025 - MLB

San Diego Padres
7 :  2
Cleveland Guardians

Mar 30, 2025 - MLB

San Diego Padres
5 :  0
Atlanta Braves

Mar 29, 2025 - MLB

San Diego Padres
1 :  0
Atlanta Braves

Mar 28, 2025 - MLB

San Diego Padres
4 :  3
Atlanta Braves
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 11, 2024 - MLB

Los Angeles Dodgers
2 :  0
San Diego Padres

Oct 6, 2024 - MLB

Los Angeles Dodgers
2 :  10
San Diego Padres

Oct 5, 2024 - MLB

Los Angeles Dodgers
7 :  5
San Diego Padres

Sep 28, 2024 - MLB

Arizona Diamondbacks
0 :  5
San Diego Padres

Sep 26, 2024 - MLB

Los Angeles Dodgers
7 :  2
San Diego Padres

Sep 25, 2024 - MLB

Los Angeles Dodgers
4 :  3
San Diego Padres

Chicago Cubs against San Diego Padres : Head to Head (H2H)

Chicago Cubs

17 %

San Diego Padres

83 %

May 7, 2024 - MLB

Chicago Cubs
3 :  2
San Diego Padres

May 6, 2024 - MLB

Chicago Cubs
3 :  6
San Diego Padres

Apr 10, 2024 - MLB

San Diego Padres
10 :  2
Chicago Cubs

Apr 8, 2024 - MLB

San Diego Padres
9 :  8
Chicago Cubs

Mar 4, 2024 - MLB Spring Training

San Diego Padres
2 :  1
Chicago Cubs

Jun 7, 2021 - MLB

San Diego Padres
9 :  4
Chicago Cubs

Chicago Cubs - San Diego Padres Key Points

  1. Betting odds are the Padres' ATS record is 6-1 this season
  2. Tatis Jr. averaged .423 to start the season with the Padres
  3. Cubs are averaging 6.7 runs this season
  4. Padres' pitching is second-best BAA in MLB at .166

Our Chicago Cubs vs San Diego Padres Prediction

Even with a 7-0 record and superb performances from the Padres' starting and relief pitching, bookmakers predict that Friday's game could very well be San Diego's first loss of the season. The Vásquez-Imanaga pitching duel seems to suit the home team. Imanaga pitched 4 scoreless innings against the Dodgers in Tokyo and then earned his first W of the season pitching 7 innings against the Diamondbacks. Our prediction for Cubs vs Padres is: Cubs -1.5.

Prediction:

 

Cubs -1.5.

+140
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Chicago Cubs vs San Diego Padres Picks