Baltimore Orioles vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Baltimore Orioles
6/12/26 19:05
San Diego Padres

Prediction:

 

The Orioles will win

-130
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 by Lou Aguila | in MLB Picks

The Baltimore Orioles eye a fifth straight victory over the San Diego Padres in Game 1 of their series.

Momentum: The Baltimore Orioles will kick off a new series feeling optimistic after winning the last two games of their series with the Seattle Mariners. The Padres also won 2 out of 3 games against the Cincinnati Reds, taking Games 1 and 3 behind clutch hitting during the late innings.

Matchup: The Orioles have won their last four meetings against the Padres. Baltimore averaged 5.67 runs per game and limited San Diego to 3.33 runs per game over their last three meetings.

Starting Pitchers: Orioles RHP Shane Baz (3-6, 4.09 ERA) has posted a 2.20 ERA over his last five starts.

Padres RHP Griffin Canning (0-4, 6.34 ERA) allowed one earned run over five innings in his latest start against the Mets on June 6. However, he has registered a 6.17 ERA across his last five mound appearances.

Hot on the Board: 61 percent of bettors have backed the Orioles to win Game 1. Caesars Sportsbooks price Baltimore at -130 moneyline and +143 to cover -1.5 runs.

Up to $250 to bet on Baltimore Orioles - San Diego Padres! 

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Baltimore Orioles vs San Diego Padres Form

Table

Teams Pts P W L
8 San Diego Padres
0.531 81 43 38
22 Baltimore Orioles
0.464 84 39 45

Baltimore Orioles and San Diego Padres Latest Matches

Baltimore Orioles
Baltimore Orioles Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 11, 2026 - MLB

Baltimore Orioles
7 :  5
Seattle Mariners

Jun 10, 2026 - MLB

Baltimore Orioles
7 :  2
Seattle Mariners

Jun 9, 2026 - MLB

Baltimore Orioles
5 :  6
Seattle Mariners

Jun 8, 2026 - MLB

Baltimore Orioles
3 :  6
Seattle Mariners

Jun 7, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles

Jun 6, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 11, 2026 - MLB

Baltimore Orioles
7 :  5
Seattle Mariners

Jun 10, 2026 - MLB

Baltimore Orioles
7 :  2
Seattle Mariners

Jun 9, 2026 - MLB

Baltimore Orioles
5 :  6
Seattle Mariners

Jun 8, 2026 - MLB

Baltimore Orioles
3 :  6
Seattle Mariners

May 31, 2026 - MLB

Baltimore Orioles
9 :  5
Toronto Blue Jays

May 30, 2026 - MLB

Baltimore Orioles
6 :  5
Toronto Blue Jays
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 7, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles

Jun 6, 2026 - MLB

Toronto Blue Jays
6 :  4
Baltimore Orioles

Jun 5, 2026 - MLB

Toronto Blue Jays
3 :  13
Baltimore Orioles

Jun 4, 2026 - MLB

Boston Red Sox
2 :  8
Baltimore Orioles

Jun 3, 2026 - MLB

Boston Red Sox
8 :  1
Baltimore Orioles

Jun 2, 2026 - MLB

Boston Red Sox
2 :  4
Baltimore Orioles
San Diego Padres
San Diego Padres Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 10, 2026 - MLB

San Diego Padres
5 :  4
Cincinnati Reds

Jun 9, 2026 - MLB

San Diego Padres
3 :  5
Cincinnati Reds

Jun 8, 2026 - MLB

San Diego Padres
6 :  2
Cincinnati Reds

Jun 7, 2026 - MLB

San Diego Padres
3 :  7
New York Mets

Jun 6, 2026 - MLB

San Diego Padres
3 :  2
New York Mets

Jun 5, 2026 - MLB

San Diego Padres
0 :  5
New York Mets
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 10, 2026 - MLB

San Diego Padres
5 :  4
Cincinnati Reds

Jun 9, 2026 - MLB

San Diego Padres
3 :  5
Cincinnati Reds

Jun 8, 2026 - MLB

San Diego Padres
6 :  2
Cincinnati Reds

Jun 7, 2026 - MLB

San Diego Padres
3 :  7
New York Mets

Jun 6, 2026 - MLB

San Diego Padres
3 :  2
New York Mets

Jun 5, 2026 - MLB

San Diego Padres
0 :  5
New York Mets
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jun 4, 2026 - MLB

Philadelphia Phillies
6 :  4
San Diego Padres

Jun 3, 2026 - MLB

Philadelphia Phillies
3 :  2
San Diego Padres

Jun 2, 2026 - MLB

Philadelphia Phillies
3 :  2
San Diego Padres

May 31, 2026 - MLB

Washington Nationals
4 :  2
San Diego Padres

May 30, 2026 - MLB

Washington Nationals
9 :  4
San Diego Padres

May 29, 2026 - MLB

Washington Nationals
5 :  7
San Diego Padres

Baltimore Orioles against San Diego Padres : Head to Head (H2H)

Baltimore Orioles

80 %

San Diego Padres

20 %

Sep 3, 2025 - MLB

San Diego Padres
5 :  7
Baltimore Orioles

Sep 2, 2025 - MLB

San Diego Padres
2 :  6
Baltimore Orioles

Sep 1, 2025 - MLB

San Diego Padres
3 :  4
Baltimore Orioles

Jul 28, 2024 - MLB

Baltimore Orioles
8 :  6
San Diego Padres

Jul 26, 2024 - MLB

Baltimore Orioles
4 :  6
San Diego Padres

Baltimore Orioles - San Diego Padres Key Points

  1. San Diego is 1-4 SU in its last 5 games against Baltimore.
  2. San Diego is 0-5 SU in its last 5 games on the road.
  3. Baltimore is 12-6 SU in its last 18 games at home.
  4. Baltimore is 13-7 SU in its last 20 games played on a Friday when playing at home.
Up to $250 to bet on Baltimore Orioles - San Diego Padres! 

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Our Baltimore Orioles vs San Diego Padres Prediction

Orioles will extend their winning streak against the Padres to five games.

Baltimore will continue to lean on their offense that has generated 5.3 runs per game on a .244 BA over the last five games. Shane Baz has never allowed more than two runs in each of his last four starts.

The Padres are hitting .249 with 4 runs per game over the last five games, which are average numbers for any ball club. However, Baltimore has posted a 4.00 ERA during this five-game stretch, with their bullpen also giving up a 4.00 ERA. It may not look that bad, but in a tight ball game, surrendering 3 or 4 runs early and having a shaky bullpen to close out would put any team in a tough spot down the stretch.

Our betting prediction for the San Diego Padres vs. the Baltimore Orioles: The Orioles will win

Prediction:

 

The Orioles will win

-130
$250 offered for betting!

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Baltimore Orioles vs San Diego Padres Picks