Arizona Diamondbacks vs San Diego Padres Prediction & Picks - MLB
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by Travis Pulver | in MLB Picks
The San Diego Padres (17-8) and Arizona Diamondbacks (14-11) will take part in the MLB World Tour with a two-game series in Mexico City this weekend, with Game One today at 6:05 p.m. EST at Estadio Alfredo Harp Helú. San Diego currently leads the NL West, with Arizona three games back in third place. Today’s contest will be the first of 13 between the two teams this season.
The Padres will give the ball to German Marquez to start the day. Marquez has gone 2-1 in four starts with a 3.86 ERA and a 1.39 WHIP. He has two outings this season where he surrendered four earned runs with multiple home runs in each. In the other two, including his last start, he did not give up a home run and pitched two shutouts.
Arizona will also send a righty to the mound to start the day, Zac Gallen. Gallen has gone 1-1 in five starts with a 3.51 ERA and a 1.48 WHIP. He did not factor into the decision in is last three outings, but the D-backs went on to win his last two. The one loss was in extra innings vs. the Mets; Gallen threw five innings, surrendering five hits, giving up four walks, and two earned runs.
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Arizona Diamondbacks vs San Diego Padres Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
10
|
0.522 | 69 | 36 | 33 |
|
15
|
0.5 | 70 | 35 | 35 |
Arizona Diamondbacks and San Diego Padres Latest Matches
3/6 (50%)
3/6 (50%)
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4/6 (67%)
2/6 (33%)
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4/6 (67%)
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6/6 (100%)
0/6 (0%)
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4/6 (67%)
2/6 (33%)
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Arizona Diamondbacks against San Diego Padres : Head to Head (H2H)
17 %
83 %
Mar 22, 2026 - MLB Spring Training
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Arizona Diamondbacks - San Diego Padres Key Points
- Arizona leads the all-time series vs. San Diego, 247-233.
- Arizona has hit .296 over the last week with 27 runs scored in five games.
- San Diego has hit .235 over the last week with 20 runs scored in five games.
- Betting Public: 46% of moneyline tickets and 22% of the handle are on the D-Backs.
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Our Arizona Diamondbacks vs San Diego Padres Prediction
I’m not sure why the public is going so heavy on the Padres. Gallen has pitched much better than Marquez has this season overall, and the D-backs lineup is hitting well. San Diego’s lineup— not so much. For all their hits, Arizona is not scoring much more than San Diego, but they are scoring enough to win. The Diamondbacks lineup has hit .311 against Marquez in 148 at-bats with six home runs. Manny Machado has hit .371 against him with one home run and seven RBI.
Our San Diego vs. Arizona Pick: Diamondbacks ML
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