San Antonio Spurs vs Portland Trail Blazers Prediction & Picks - NBA

USA - NBA

San Antonio Spurs
11/26/25 22:00
Portland Trail Blazers

Prediction:

 

Spurs (+1.5) cover the spread

-108
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 by Paul Tamayo in NBA Picks

The San Antonio Spurs (11-5) visit the Portland Trail Blazers (8-10) in an NBA 2025-26 game on Wednesday, November 26, at the Moda Center.

The Blazers return home riding momentum after a 115-103 road win over the Milwaukee Bucks. Jerami Grant erupted for 35 points as Portland dominated from the free-throw line and knocked down 18 threes to finish a 2-1 road trip.

Portland continues to defy expectations this season, as they're sitting 9th in the stacked Western Conference. However, they're dealing with tons of injuries to their key players, including Jrue Holiday, Damian Lillard, Scoot Henderson, Shaedon Sharpe, and Matisse Thybulle.

As for the Spurs, they’ve cooled slightly after a hot start. San Antonio’s 11-5 record still has them near the top of the Western Conference, but they’re coming off a 111-102 road loss to the Phoenix Suns.

The Spurs built an early seven-point lead at halftime, but gave up 37 points to the Suns in the third quarter. De'Aaron Fox had a team-high 26 markers in the loss. Devin Vassell added 17, but he only shot 38.5% from the field.

San Antonio is also hampered by numerous injuries. They'll be missing the services of Victor Wembanyama, Stephon Castle, and Dylan Harper.

San Antonio Spurs vs Portland Trail Blazers Form

Table

Teams % P W L Series
5
San Antonio Spurs
San Antonio Spurs
0.688 16 11 5 -1
9
Portland Trail Blazers
Portland Trail Blazers
0.444 18 8 10 1

San Antonio Spurs and Portland Trail Blazers Latest Matches

San Antonio Spurs
San Antonio Spurs Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 23, 2025 - NBA

San Antonio Spurs
102 :  111
Phoenix Suns

Nov 20, 2025 - NBA

Atlanta Hawks
126 :  135
San Antonio Spurs

Nov 18, 2025 - NBA

Memphis Grizzlies
101 :  111
San Antonio Spurs

Nov 16, 2025 - NBA

Sacramento Kings
110 :  123
San Antonio Spurs

Nov 14, 2025 - NBA

Golden State Warriors
109 :  108
San Antonio Spurs

Nov 12, 2025 - NBA

Golden State Warriors
125 :  120
San Antonio Spurs
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 20, 2025 - NBA

Atlanta Hawks
126 :  135
San Antonio Spurs

Nov 18, 2025 - NBA

Memphis Grizzlies
101 :  111
San Antonio Spurs

Nov 16, 2025 - NBA

Sacramento Kings
110 :  123
San Antonio Spurs

Nov 14, 2025 - NBA

Golden State Warriors
109 :  108
San Antonio Spurs

Nov 12, 2025 - NBA

Golden State Warriors
125 :  120
San Antonio Spurs

Nov 8, 2025 - NBA

New Orleans Pelicans
119 :  126
San Antonio Spurs
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 23, 2025 - NBA

San Antonio Spurs
102 :  111
Phoenix Suns

Nov 10, 2025 - NBA

San Antonio Spurs
121 :  117
Chicago Bulls

Nov 5, 2025 - NBA

San Antonio Spurs
116 :  118
Los Angeles Lakers

Nov 2, 2025 - NBA

San Antonio Spurs
118 :  130
Phoenix Suns

Oct 24, 2025 - NBA

San Antonio Spurs
120 :  116
New Orleans Pelicans

Oct 22, 2025 - NBA

San Antonio Spurs
125 :  92
Dallas Mavericks
Portland Trail Blazers
Portland Trail Blazers Latest matches
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 24, 2025 - NBA

Portland Trail Blazers
115 :  103
Milwaukee Bucks

Nov 23, 2025 - NBA

Portland Trail Blazers
95 :  122
Oklahoma City Thunder

Nov 21, 2025 - NBA

Portland Trail Blazers
127 :  123
Golden State Warriors

Nov 19, 2025 - NBA

Chicago Bulls
122 :  121
Portland Trail Blazers

Nov 18, 2025 - NBA

Phoenix Suns
127 :  110
Portland Trail Blazers

Nov 16, 2025 - NBA

Portland Trail Blazers
133 :  138
Dallas Mavericks
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 19, 2025 - NBA

Chicago Bulls
122 :  121
Portland Trail Blazers

Nov 18, 2025 - NBA

Phoenix Suns
127 :  110
Portland Trail Blazers

Nov 5, 2025 - NBA

Oklahoma City Thunder
119 :  121
Portland Trail Blazers

Nov 3, 2025 - NBA

Los Angeles Lakers
123 :  115
Portland Trail Blazers

Oct 31, 2025 - NBA

Denver Nuggets
107 :  109
Portland Trail Blazers

Oct 24, 2025 - NBA

Golden State Warriors
119 :  139
Portland Trail Blazers
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 24, 2025 - NBA

Portland Trail Blazers
115 :  103
Milwaukee Bucks

Nov 23, 2025 - NBA

Portland Trail Blazers
95 :  122
Oklahoma City Thunder

Nov 21, 2025 - NBA

Portland Trail Blazers
127 :  123
Golden State Warriors

Nov 16, 2025 - NBA

Portland Trail Blazers
133 :  138
Dallas Mavericks

Nov 14, 2025 - NBA

Portland Trail Blazers
116 :  140
Houston Rockets

Nov 12, 2025 - NBA

Portland Trail Blazers
125 :  117
New Orleans Pelicans

San Antonio Spurs against Portland Trail Blazers : Head to Head (H2H)

San Antonio Spurs

67 %

Portland Trail Blazers

33 %

Apr 6, 2025 - NBA

San Antonio Spurs
109 :  120
Portland Trail Blazers

Dec 21, 2024 - NBA

Portland Trail Blazers
94 :  114
San Antonio Spurs

Dec 13, 2024 - NBA

San Antonio Spurs
118 :  116
Portland Trail Blazers

Nov 7, 2024 - NBA

Portland Trail Blazers
105 :  118
San Antonio Spurs

Jan 26, 2024 - NBA

Portland Trail Blazers
100 :  116
San Antonio Spurs

Dec 29, 2023 - NBA

San Antonio Spurs
128 :  134
Portland Trail Blazers

San Antonio Spurs - Portland Trail Blazers Key Points

  1. The Blazers are coming off a 115-103 win against the Milwaukee Bucks.
  2. The Spurs are coming off a 111-102 loss to the Phoenix Suns.
  3. The Blazers will miss the services of Jrue Holiday, Damian Lillard, Scoot Henderson, Shaedon Sharpe, and Matisse Thybulle.
  4. The Spurs will miss the services of Victor Wembanyama, Stephon Castle, and Dylan Harper.

Our San Antonio Spurs vs Portland Trail Blazers Prediction

After a confidence-boosting road performance in Milwaukee, Portland now gets a short-handed Spurs team at home with massive NBA Cup stakes. San Antonio has been excellent overall, but without Victor Wembanyama’s rim protection and interior scoring, they lose their primary mismatch on both ends.

But don't expect the Blazers to run away with this game, as they're also dealing with a handful of injuries to their key players. Our prediction for the Portland Trail Blazers vs San Antonio Spurs match is: Spurs (+1.5) cover the spread.

Prediction:

 

Spurs (+1.5) cover the spread

-108
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San Antonio Spurs vs Portland Trail Blazers Picks