San Antonio Spurs vs Memphis Grizzlies Prediction & Picks - NBA
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by Paul Tamayo in NBA Picks
The Memphis Grizzlies (15-20) host the San Antonio Spurs (25-10) in an NBA 2025-26 game on Tuesday, January 6, at FedExForum.
The Spurs enter this matchup holding a 2-0 head-to-head advantage over the Grizzlies this season, winning 111-101 in San Antonio on November 18 and 126-119 on December 2.
However, the Spurs are coming off a 115-110 loss to the Portland Trail Blazers, as they struggled without star Victor Wembanyama. The Blazers raced to an 11-point lead after the first quarter, setting the tone for the whole game. All five Spurs starters scored in double digits, including Luke Kornet with the team-high 23.
As for the Grizzlies, they have been in a rough stretch of four straight losses. Recently, they were handed a 120-114 defeat by the Los Angeles Lakers, as their offense sputtered in the second half.
Offense has been a weakness for the Grizzlies this season. They're only ranked 24th in offensive rating, as they continue to miss key players for a significant period.
On Tuesday, the Grizzlies will miss the services of Cedric Coward, Zach Edey, Ty Jerome, Scotty Pippen Jr., Brandon Clarke, and John Konchar. Ja Morant is listed as questionable due to a calf injury.
Meanwhile, the Spurs will be without Victor Wembanyama and Devin Vassell.
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San Antonio Spurs vs Memphis Grizzlies Form
Table
| Teams | % | P | W | L | Series |
|---|---|---|---|---|---|
|
2
|
0.703 | 37 | 26 | 11 | 1 |
|
10
|
0.432 | 37 | 16 | 21 | -1 |
San Antonio Spurs and Memphis Grizzlies Latest Matches
3/6 (50%)
3/6 (50%)
Jan 3, 2026 - NBA
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3/6 (50%)
3/6 (50%)
Jan 3, 2026 - NBA
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5/6 (83%)
1/6 (17%)
Jan 2, 2026 - NBA
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2/6 (33%)
4/6 (67%)
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3/6 (50%)
3/6 (50%)
Dec 30, 2025 - NBA
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2/6 (33%)
4/6 (67%)
Jan 4, 2026 - NBA
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San Antonio Spurs against Memphis Grizzlies : Head to Head (H2H)
50 %
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Dec 2, 2025 - NBA
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San Antonio Spurs - Memphis Grizzlies Key Points
- The Spurs enter this matchup holding a 2-0 head-to-head advantage over the Grizzlies.
- The Grizzlies have lost four straight games.
- The Spurs have a better offensive and defensive rating.
- The Grizzlies will miss the services of Cedric Coward, Zach Edey, Ty Jerome, Scotty Pippen Jr., Brandon Clarke, and John Konchar.
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Our San Antonio Spurs vs Memphis Grizzlies Prediction
San Antonio’s overall depth and efficiency, even when banged up, give them the edge in this matchup. They've also won their first two games against the Grizzlies this season.
Moreover, the Grizzlies are missing half of their key rotational pieces, including Cedric Coward and Zach Edey. Even without Victor Wembanyama and Devin Vassell, the Spurs' ability to win without full strength suggests they cover the spread on Tuesday. Our prediction for the Memphis Grizzlies vs San Antonio Spurs match is: Spurs (-5.5) cover the spread.Grab an extra $300 for your San Antonio Spurs vs Memphis Grizzlies wager!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.