San Antonio Spurs vs Los Angeles Lakers Prediction & Picks - NBA

USA - NBA

San Antonio Spurs
12/10/25 22:00
Los Angeles Lakers

Prediction:

 

Lakers (-5.5) cover the spread

-114
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 by Paul Tamayo in NBA Picks

The San Antonio Spurs (16-7) visit the Los Angeles Lakers (17-6) in an NBA Cup quarterfinals game on Wednesday, December 10, at the Crypto.com Arena. 

The Lakers look to keep their strong start going when they host the Spurs on Wednesday. They are coming off an impressive 112-108 win over the Philadelphia 76ers, where they erased a seven-point halftime deficit behind LeBron James’ late go-ahead three. 

Along with LeBron's heroics, Luka Doncic also came through with a triple-double performance of 31 points, 15 rebounds, and 11 assists. 

It has been a lukewarm stretch for the Lakers, as they lost two of their last five games. This recent road win against the Sixers should be a morale booster for the team.

As for the Spurs, they’ve won four of their last five games and are fresh off a wild 135-132 victory over the New Orleans Pelicans. San Antonio built a 20-point halftime lead, then nearly collapsed in the third quarter before rookie Dylan Harper’s go-ahead floater with nine seconds left sealed the win.

Harper finished with 22 markers, reinforcing veteran forward Harrison Barnes, who had a team-high 24. 

The Spurs will continue to miss Victor Wembanyama on Wednesday, while the Lakers have Maxi Kleber listed as day-to-day.

San Antonio Spurs vs Los Angeles Lakers Form

Table

Teams % P W L Series
2
Los Angeles Lakers
Los Angeles Lakers
0.739 23 17 6 1
5
San Antonio Spurs
San Antonio Spurs
0.696 23 16 7 1

San Antonio Spurs and Los Angeles Lakers Latest Matches

San Antonio Spurs
San Antonio Spurs Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 8, 2025 - NBA

San Antonio Spurs
135 :  132
New Orleans Pelicans

Dec 5, 2025 - NBA

San Antonio Spurs
117 :  130
Cleveland Cavaliers

Dec 3, 2025 - NBA

San Antonio Spurs
114 :  112
Orlando Magic

Dec 2, 2025 - NBA

Memphis Grizzlies
119 :  126
San Antonio Spurs

Nov 30, 2025 - NBA

San Antonio Spurs
112 :  125
Minnesota Timberwolves

Nov 28, 2025 - NBA

San Antonio Spurs
139 :  136
Denver Nuggets
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 2, 2025 - NBA

Memphis Grizzlies
119 :  126
San Antonio Spurs

Nov 20, 2025 - NBA

Atlanta Hawks
126 :  135
San Antonio Spurs

Nov 18, 2025 - NBA

Memphis Grizzlies
101 :  111
San Antonio Spurs

Nov 16, 2025 - NBA

Sacramento Kings
110 :  123
San Antonio Spurs

Nov 14, 2025 - NBA

Golden State Warriors
109 :  108
San Antonio Spurs

Nov 12, 2025 - NBA

Golden State Warriors
125 :  120
San Antonio Spurs
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 8, 2025 - NBA

San Antonio Spurs
135 :  132
New Orleans Pelicans

Dec 5, 2025 - NBA

San Antonio Spurs
117 :  130
Cleveland Cavaliers

Dec 3, 2025 - NBA

San Antonio Spurs
114 :  112
Orlando Magic

Nov 30, 2025 - NBA

San Antonio Spurs
112 :  125
Minnesota Timberwolves

Nov 28, 2025 - NBA

San Antonio Spurs
139 :  136
Denver Nuggets

Nov 26, 2025 - NBA

San Antonio Spurs
115 :  102
Portland Trail Blazers
Los Angeles Lakers
Los Angeles Lakers Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 7, 2025 - NBA

Los Angeles Lakers
112 :  108
Philadelphia 76ers

Dec 5, 2025 - NBA

Los Angeles Lakers
105 :  126
Boston Celtics

Dec 4, 2025 - NBA

Los Angeles Lakers
123 :  120
Toronto Raptors

Dec 1, 2025 - NBA

Phoenix Suns
125 :  108
Los Angeles Lakers

Nov 30, 2025 - NBA

New Orleans Pelicans
121 :  133
Los Angeles Lakers

Nov 28, 2025 - NBA

Dallas Mavericks
119 :  129
Los Angeles Lakers
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 1, 2025 - NBA

Phoenix Suns
125 :  108
Los Angeles Lakers

Nov 30, 2025 - NBA

New Orleans Pelicans
121 :  133
Los Angeles Lakers

Nov 28, 2025 - NBA

Dallas Mavericks
119 :  129
Los Angeles Lakers

Nov 25, 2025 - NBA

LA Clippers
118 :  135
Los Angeles Lakers

Nov 18, 2025 - NBA

Utah Jazz
126 :  140
Los Angeles Lakers

Nov 5, 2025 - NBA

San Antonio Spurs
116 :  118
Los Angeles Lakers
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 7, 2025 - NBA

Los Angeles Lakers
112 :  108
Philadelphia 76ers

Dec 5, 2025 - NBA

Los Angeles Lakers
105 :  126
Boston Celtics

Dec 4, 2025 - NBA

Los Angeles Lakers
123 :  120
Toronto Raptors

Nov 23, 2025 - NBA

Los Angeles Lakers
108 :  106
Utah Jazz

Nov 15, 2025 - NBA

Los Angeles Lakers
119 :  95
Milwaukee Bucks

Nov 14, 2025 - NBA

Los Angeles Lakers
118 :  104
New Orleans Pelicans

San Antonio Spurs against Los Angeles Lakers : Head to Head (H2H)

San Antonio Spurs

17 %

Los Angeles Lakers

83 %

Nov 5, 2025 - NBA

San Antonio Spurs
116 :  118
Los Angeles Lakers

Jul 8, 2025 - NBA Summer League

Los Angeles Lakers
89 :  88
San Antonio Spurs

Mar 17, 2025 - NBA

San Antonio Spurs
109 :  125
Los Angeles Lakers

Jan 13, 2025 - NBA

San Antonio Spurs
126 :  102
Los Angeles Lakers

Nov 27, 2024 - NBA

Los Angeles Lakers
119 :  101
San Antonio Spurs

Nov 15, 2024 - NBA

Los Angeles Lakers
120 :  115
San Antonio Spurs

San Antonio Spurs - Los Angeles Lakers Key Points

  1. The Lakers are coming off a 112-108 win against the Philadelphia 76ers.
  2. The Spurs are coming off a 135-132 win over the New Orleans Pelicans.
  3. The Lakers have a better offensive rating than the Spurs.
  4. The Spurs have won four of their last five games.

Our San Antonio Spurs vs Los Angeles Lakers Prediction

After their clutch victory in Philadelphia, the Lakers return home with much-needed momentum. LeBron James played in his best form since his return, and they all have their stars healthy for this NBA Cup quarterfinals match on Wednesday.

Meanwhile, the Spurs have been impressive recently, but they're still missing the services of their dynamic big man Victor Wembanyama. The healthy Lakers have the advantage in this game. Our prediction for the Los Angeles Lakers vs San Antonio Spurs match is: Lakers (-5.5) cover the spread.

Prediction:

 

Lakers (-5.5) cover the spread

-114
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San Antonio Spurs vs Los Angeles Lakers Picks