Chicago Cubs vs Pittsburgh Pirates Prediction & Picks - MLB

USA - MLB

Chicago Cubs
9/13/26 14:20
Pittsburgh Pirates

Prediction:

 

Over 6.5

−125
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 by Bill Christy | in MLB Picks

The Chicago Cubs are looking to sweep the Pittsburgh Pirates this afternoon at Wrigley. They have taken the 1st two games by a total of 11 runs, but the games were very different.

In game one, the Pirates could not stop the Cubs from hitting any of their pitching. They used 3 different pitchers, and each one allowed at least 3 runs during their work. All Cubs hitters that started the game contributed with either a hit or a run scored. Michael Busch and Alex Bregman were the driving force in the game. They combined to go 5-for-8 with 2 doubles, a home run, and 5 total RBIs. They were able to dispatch the Pirates with a 12-2 victory.

Game two was much tighter. Paul Skenes pitched 7 strong innings for the Pirates. He exited after the 7th inning with a 3-2 lead. However, Gregory Soto came in and allowed 2 runs in the bottom of the 8th. He walked in the tying run and then hit Nico Hoerner to give the Cubs the lead that they were able to hold onto for the 4-3 win.

Bubba Chandler and Matthew Boyd are the slated starters for this last game of the series. Both starters carry an ERA over 4.00 on the season. They are going to have a hard time against these strong hitting lineups this afternoon

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Chicago Cubs vs Pittsburgh Pirates Form

Table

Teams Pts P W L
7 Chicago Cubs
0.549 162 89 73
13 Pittsburgh Pirates
0.506 162 82 80

Chicago Cubs and Pittsburgh Pirates Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Sep 9, 2026 - MLB

Milwaukee Brewers
8 :  6
Chicago Cubs

Sep 8, 2026 - MLB

Milwaukee Brewers
4 :  3
Chicago Cubs

Sep 7, 2026 - MLB

Milwaukee Brewers
4 :  3
Chicago Cubs

Sep 6, 2026 - MLB

Miami Marlins
10 :  3
Chicago Cubs
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Sep 3, 2026 - MLB

Chicago Cubs
2 :  1
Milwaukee Brewers

Sep 2, 2026 - MLB

Chicago Cubs
5 :  9
Milwaukee Brewers

Sep 1, 2026 - MLB

Chicago Cubs
4 :  9
Milwaukee Brewers

Aug 31, 2026 - MLB

Chicago Cubs
17 :  3
Milwaukee Brewers
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 9, 2026 - MLB

Milwaukee Brewers
8 :  6
Chicago Cubs

Sep 8, 2026 - MLB

Milwaukee Brewers
4 :  3
Chicago Cubs

Sep 7, 2026 - MLB

Milwaukee Brewers
4 :  3
Chicago Cubs

Sep 6, 2026 - MLB

Miami Marlins
10 :  3
Chicago Cubs

Sep 5, 2026 - MLB

Miami Marlins
5 :  6
Chicago Cubs

Sep 4, 2026 - MLB

Miami Marlins
1 :  6
Chicago Cubs
Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Sep 10, 2026 - MLB

Chicago White Sox
0 :  2
Pittsburgh Pirates

Sep 9, 2026 - MLB

Chicago White Sox
2 :  4
Pittsburgh Pirates

Sep 8, 2026 - MLB

Chicago White Sox
3 :  9
Pittsburgh Pirates

Sep 6, 2026 - MLB

Pittsburgh Pirates
1 :  0
Los Angeles Angels
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 6, 2026 - MLB

Pittsburgh Pirates
1 :  0
Los Angeles Angels

Sep 5, 2026 - MLB

Pittsburgh Pirates
1 :  6
Los Angeles Angels

Sep 4, 2026 - MLB

Pittsburgh Pirates
1 :  0
Los Angeles Angels

Sep 3, 2026 - MLB

Pittsburgh Pirates
5 :  2
San Francisco Giants

Sep 2, 2026 - MLB

Pittsburgh Pirates
4 :  5
San Francisco Giants

Sep 1, 2026 - MLB

Pittsburgh Pirates
13 :  12
San Francisco Giants
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Sep 10, 2026 - MLB

Chicago White Sox
0 :  2
Pittsburgh Pirates

Sep 9, 2026 - MLB

Chicago White Sox
2 :  4
Pittsburgh Pirates

Sep 8, 2026 - MLB

Chicago White Sox
3 :  9
Pittsburgh Pirates

Aug 30, 2026 - MLB

St. Louis Cardinals
4 :  5
Pittsburgh Pirates

Chicago Cubs against Pittsburgh Pirates : Head to Head (H2H)

Chicago Cubs

83 %

Pittsburgh Pirates

17 %

Sep 12, 2026 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates

Sep 11, 2026 - MLB

Chicago Cubs
12 :  2
Pittsburgh Pirates

Jul 26, 2026 - MLB

Pittsburgh Pirates
8 :  7
Chicago Cubs

Jul 25, 2026 - MLB

Pittsburgh Pirates
0 :  11
Chicago Cubs

Jul 24, 2026 - MLB

Pittsburgh Pirates
2 :  3
Chicago Cubs

May 28, 2026 - MLB

Pittsburgh Pirates
2 :  7
Chicago Cubs
Chicago Cubs vs Pittsburgh Pirates Picks

Chicago Cubs - Pittsburgh Pirates Key Points

  1. Over is 7-1 in Boyds last 8 starts as a home favorite.
  2. Over is 8-1 in Boyds last 9 home starts.
  3. Over is 4-0 in Wills' last 4 games behind home plate vs. Pittsburgh.
  4. Over is 4-0 in Cubs last 4 during game 3 of a series.

Our Chicago Cubs vs Pittsburgh Pirates Prediction

Pittsburgh is 5th in the MLB in total runs scored this season. The top team are these Chicago Cubs. They are both inside the top 5 in combined batting average, and each is outside the top 15 in combined ERA. We like these explosive teams to combine for double-digit runs once again in this final matchup of their series.

Our prediction for Chicago Cubs vs Pittsburgh Pirates: Over 6.5

Prediction:

 

Over 6.5

−125
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.