New York Mets vs Philadelphia Phillies Prediction & Picks - MLB

Prediction published on 4/21/25, 3:31 PM  by Carlos Zabala | Modified on 2/11/26 at 8:38 AM in MLB Picks

In the most anticipated series in MLB starting Monday, the Phillies and Mets will face off at Citi Field. After the memorable playoff series where they won one in Philadelphia and two in Queens, the Mets eliminated the Phillies in 2024.

Nola against Megill will be the pitching duel for the first Mets-Phillies game of the year. So far in 2025, every team that has gone to Citi Field has been dominated by the Mets' starting pitching staff and bullpen in a pitching stadium that has the Mets with an O/U betting record of 7-15.

The Mets completed a four-game sweep on Sunday against the Cardinals. Lindor's walk-off homer in Game 3 fueled him to continue in Game 4, where he batted 3-for-5 with an RBI and a HR. Soto, after receiving a standing ovation from his home crowd in support of the relentless criticism, responded on Sunday by going 2-for-3 and driving in 3 of the Mets' 7 runs, boosting his AVG.

Meanwhile, the Phillies could have also swept the Marlins in Philadelphia, but poor relief in Game 2 complicated a sure victory, and Game 3 ultimately cost them the game. Between the relievers, Kerkering and Strahm allowed 5 ER.