Philadelphia 76ers vs Cleveland Cavaliers Prediction & Picks - NBA

USA - NBA

Philadelphia 76ers
11/5/25 19:00
Cleveland Cavaliers

Prediction:

 

The Sixers +10.5 Points

-115
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 by Lou Aguila | in NBA Picks

The Cleveland Cavaliers and the Philadelphia 76ers meet for the first time this season on Wednesday at Rocket Arena.

The Sixers are listed as +10.5-point underdogs against the Cavaliers despite parading a 5-2 record through the first two weeks of the season.

Current Form:

Philadelphia suffered its second loss in three games after coming up short against the resurging Chicago Bulls 111-113. Tyrese Maxey dropped 39 points, 5 rebounds, and 5 assists, while Joel Embiid and Kelly Oubre chipped in 20 and 18 points, respectively. The Sixers had an 11-point lead, 95-84, at the end of the first period, but they let Chicago outscore them 29-16 in the payoff period.

After back-to-back losses to Boston 105-125, and Toronto 101-112, the Cavaliers returned to the winner’s circle after downing the Atlanta Hawks 117-109. Donovan Mitchell exploded for 37 points and De’Andre Hunter added 19 points for the short-handed Cavs, who missed All-Star Jarrett Allen, Evan Mobley, and Darius Garland due to injuries. The Cavs improved to 4-3 in the season and 2-1 at home.

Philadelphia 76ers vs Cleveland Cavaliers Form

Table

Teams % P W L Series
4
Philadelphia 76ers
Philadelphia 76ers
0.571 28 16 12 -1
7
Cleveland Cavaliers
Cleveland Cavaliers
0.548 31 17 14 2

Philadelphia 76ers and Cleveland Cavaliers Latest Matches

Philadelphia 76ers
Philadelphia 76ers Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 4, 2025 - NBA

Philadelphia 76ers
111 :  113
Chicago Bulls

Nov 2, 2025 - NBA

Philadelphia 76ers
129 :  105
Brooklyn Nets

Oct 31, 2025 - NBA

Boston Celtics
109 :  108
Philadelphia 76ers

Oct 28, 2025 - NBA

Philadelphia 76ers
139 :  134
Washington Wizards

Oct 27, 2025 - NBA

Orlando Magic
124 :  136
Philadelphia 76ers

Oct 25, 2025 - NBA

Charlotte Hornets
121 :  125
Philadelphia 76ers
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 31, 2025 - NBA

Boston Celtics
109 :  108
Philadelphia 76ers

Oct 27, 2025 - NBA

Orlando Magic
124 :  136
Philadelphia 76ers

Oct 25, 2025 - NBA

Charlotte Hornets
121 :  125
Philadelphia 76ers

Jul 16, 2025 - NBA Summer League

Dallas Mavericks
82 :  90
Philadelphia 76ers

Jul 12, 2025 - NBA Summer League

Charlotte Hornets
96 :  94
Philadelphia 76ers

Jul 10, 2025 - NBA Summer League

San Antonio Spurs
111 :  70
Philadelphia 76ers
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 4, 2025 - NBA

Philadelphia 76ers
111 :  113
Chicago Bulls

Nov 2, 2025 - NBA

Philadelphia 76ers
129 :  105
Brooklyn Nets

Oct 28, 2025 - NBA

Philadelphia 76ers
139 :  134
Washington Wizards

Oct 22, 2025 - NBA

Philadelphia 76ers
117 :  116
Boston Celtics

Jul 18, 2025 - NBA Summer League

Philadelphia 76ers
87 :  83
Brooklyn Nets

Jul 15, 2025 - NBA Summer League

Philadelphia 76ers
74 :  58
Washington Wizards
Cleveland Cavaliers
Cleveland Cavaliers Latest matches
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 2, 2025 - NBA

Atlanta Hawks
109 :  117
Cleveland Cavaliers

Oct 31, 2025 - NBA

Toronto Raptors
112 :  101
Cleveland Cavaliers

Oct 29, 2025 - NBA

Cleveland Cavaliers
105 :  125
Boston Celtics

Oct 27, 2025 - NBA

Cleveland Cavaliers
116 :  95
Detroit Pistons

Oct 26, 2025 - NBA

Milwaukee Bucks
113 :  118
Cleveland Cavaliers

Oct 24, 2025 - NBA

Cleveland Cavaliers
131 :  124
Brooklyn Nets
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 2, 2025 - NBA

Atlanta Hawks
109 :  117
Cleveland Cavaliers

Oct 31, 2025 - NBA

Toronto Raptors
112 :  101
Cleveland Cavaliers

Oct 26, 2025 - NBA

Milwaukee Bucks
113 :  118
Cleveland Cavaliers

Jul 16, 2025 - NBA Summer League

Sacramento Kings
94 :  86
Cleveland Cavaliers

Jul 13, 2025 - NBA Summer League

Miami Heat
72 :  92
Cleveland Cavaliers

May 13, 2025 - NBA

Indiana Pacers
114 :  105
Cleveland Cavaliers
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 29, 2025 - NBA

Cleveland Cavaliers
105 :  125
Boston Celtics

Oct 27, 2025 - NBA

Cleveland Cavaliers
116 :  95
Detroit Pistons

Oct 24, 2025 - NBA

Cleveland Cavaliers
131 :  124
Brooklyn Nets

Oct 22, 2025 - NBA

Cleveland Cavaliers
111 :  119
New York Knicks

Jul 19, 2025 - NBA Summer League

Cleveland Cavaliers
71 :  82
Golden State Warriors

Jul 12, 2025 - NBA Summer League

Cleveland Cavaliers
93 :  83
Milwaukee Bucks

Philadelphia 76ers against Cleveland Cavaliers : Head to Head (H2H)

Philadelphia 76ers

50 %

Cleveland Cavaliers

50 %

Jan 24, 2025 - NBA

Cleveland Cavaliers
129 :  132
Philadelphia 76ers

Dec 21, 2024 - NBA

Philadelphia 76ers
99 :  126
Cleveland Cavaliers

Nov 13, 2024 - NBA

Cleveland Cavaliers
114 :  106
Philadelphia 76ers

Mar 29, 2024 - NBA

Philadelphia 76ers
114 :  117
Cleveland Cavaliers

Feb 23, 2024 - NBA

Cleveland Cavaliers
97 :  104
Philadelphia 76ers

Feb 12, 2024 - NBA

Philadelphia 76ers
123 :  121
Cleveland Cavaliers

Players list

Philadelphia 76ers
Philadelphia 76ers
A. Bona K. Oubre Jr. V. Edgecombe T. Maxey J. Walker
Cleveland Cavaliers
Cleveland Cavaliers
J. Allen D. Mitchell D. Garland E. Mobley J. Tyson

Substitutes

Philadelphia 76ers
Philadelphia 76ers
A. Drummond J. Broome E. Gordon H. Sallis J. Edwards K. Lowry Q. Grimes T. Watford
Cleveland Cavaliers
Cleveland Cavaliers
L. Nance Jr. T. Bryant D. Wade C. Porter T. Proctor S. Merrill L. Ball N. Tomlin

Philadelphia 76ers - Cleveland Cavaliers Key Points

  1. Philadelphia is 5-2 SU in its last 7 games.
  2. Philadelphia is 5-1 ATS in its last 6 games against Cleveland.
  3. Cleveland is 2-7 ATS in its last 9 games.
  4. Cleveland is 1-6 ATS in its last 7 games at home.

Our Philadelphia 76ers vs Cleveland Cavaliers Prediction

Fearless Forecast: The Sixers are an enticing bet to cover the spread with a +10.5-point head start. Philadelphia looks like a playoff contender in the East after its first seven games this season. Tyrese Maxey continues to be a bucket, but he’s getting help from rookie VJ Edgecombe and Kelly Oubre Jr. Joel Embiid is steadily getting back to form after battling with injuries in the past two seasons. The Cavs could get back the service of Darius Garland and Jarrett Allen, but still, I believe the Sixers can go toe-to-toe with the Cavs in this matchup, especially if Maxey, Edgecombe and Embiid deliver strong numbers.

Our betting prediction for the Cleveland Cavaliers vs. the Philadelphia 76ers: the Sixers +10.5 Points

Prediction:

 

The Sixers +10.5 Points

-115
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Philadelphia 76ers vs Cleveland Cavaliers Picks