Oregon Ducks vs Penn State Nittany Lions Prediction & Picks - NCAA

USA - NCAA

Oregon Ducks
9/27/25 19:30
Penn State Nittany Lions

Prediction:

 

Oregon Ducks +3.5

-112
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 by Matt Lowrimore | in NCAA Picks

Perhaps the best game on the Week 5 college football Saturday slate will see the 6th-ranked Oregon Ducks take on the 3rd-ranked Penn State Nittany Lions. Let’s take a look at the match statistics and predictions for this game between the Ducks and Nittany Lions.

Oregon enters this game with a record of 4-0 and 1-0 in the Big Ten. The Ducks most recently beat the Oregon State Beavers in Week 4 by a score of 41-7. Oregon’s offense had a total of 585 yards, while its defense allowed 147 yards. Quarterback Dante Moore threw for 305 yards and four touchdowns, while running back Jayden Limar led the team in rushing with 70 yards.

As for Penn State, they enter this game with a record of 3-0, and this will be their first Big Ten game of the season. The Nittany Lions most recently beat the Villanova Wildcats in week 3 by a score of 52-6. Penn State’s offense had a total of 465 yards, while its defense allowed 179 yards. Quarterback Drew Allar threw for 209 yards, one touchdown, and one interception, while running back Kaytron Allen led the team in rushing with 86 yards and one touchdown.

Oregon Ducks vs Penn State Nittany Lions Form

Table

Teams % P W D L
3
Oregon Ducks
Oregon Ducks
0.889 9 8 0 1
13
Penn State Nittany Lions
Penn State Nittany Lions
0.333 9 3 0 6

Oregon Ducks and Penn State Nittany Lions Latest Matches

Oregon Ducks
Oregon Ducks Latest matches
W L W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 20, 2025 - NCAA

Oregon State Beavers
7 :  41
Oregon Ducks

Sep 13, 2025 - NCAA

Oregon Ducks
34 :  14
Northwestern Wildcats

Sep 6, 2025 - NCAA

Oklahoma State Cowboys
3 :  69
Oregon Ducks

Aug 30, 2025 - NCAA

Montana State Bobcats
13 :  59
Oregon Ducks

Jan 1, 2025 - NCAA

Ohio State Buckeyes
41 :  21
Oregon Ducks

Oct 4, 2024 - NCAA

Michigan State Spartans
10 :  31
Oregon Ducks
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 20, 2025 - NCAA

Oregon State Beavers
7 :  41
Oregon Ducks

Sep 6, 2025 - NCAA

Oklahoma State Cowboys
3 :  69
Oregon Ducks

Aug 30, 2025 - NCAA

Montana State Bobcats
13 :  59
Oregon Ducks

Jan 1, 2025 - NCAA

Ohio State Buckeyes
41 :  21
Oregon Ducks

Oct 4, 2024 - NCAA

Michigan State Spartans
10 :  31
Oregon Ducks

Sep 7, 2024 - NCAA

Boise State Broncos
34 :  37
Oregon Ducks
W W W W W
Victories

2/2 (100%)

Draw

0/2 (0%)

Defeats

0/2 (0%)

Sep 13, 2025 - NCAA

Oregon Ducks
34 :  14
Northwestern Wildcats

Sep 28, 2024 - NCAA

Oregon Ducks
34 :  13
UCLA Bruins
Penn State Nittany Lions
Penn State Nittany Lions Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

Villanova Wildcats
6 :  52
Penn State Nittany Lions

Sep 6, 2025 - NCAA

FIU Panthers
0 :  34
Penn State Nittany Lions

Aug 30, 2025 - NCAA

Nevada Wolf Pack
11 :  46
Penn State Nittany Lions

Jan 9, 2025 - NCAA

Notre Dame Fighting Irish
27 :  24
Penn State Nittany Lions

Dec 31, 2024 - NCAA

Penn State Nittany Lions
31 :  14
Boise State Broncos

Dec 21, 2024 - NCAA

SMU Mustangs
10 :  38
Penn State Nittany Lions
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 13, 2025 - NCAA

Villanova Wildcats
6 :  52
Penn State Nittany Lions

Sep 6, 2025 - NCAA

FIU Panthers
0 :  34
Penn State Nittany Lions

Aug 30, 2025 - NCAA

Nevada Wolf Pack
11 :  46
Penn State Nittany Lions

Jan 9, 2025 - NCAA

Notre Dame Fighting Irish
27 :  24
Penn State Nittany Lions

Dec 21, 2024 - NCAA

SMU Mustangs
10 :  38
Penn State Nittany Lions

Oct 5, 2024 - NCAA

UCLA Bruins
11 :  27
Penn State Nittany Lions
W W W W L W
Victories

1/1 (100%)

Draw

0/1 (0%)

Defeats

0/1 (0%)

Dec 31, 2024 - NCAA

Penn State Nittany Lions
31 :  14
Boise State Broncos

Oregon Ducks - Penn State Nittany Lions Key Points

  1. Penn State is 0-3 ATS this season
  2. Oregon is 2-2 ATS this season
  3. Oregon is averaging 51.3 points per game this season
  4. Penn State is averaging 44.0 points per game this season

Our Oregon Ducks vs Penn State Nittany Lions Prediction

It is a little surprising that Penn State is the favorite in this game, as they have not been very impressive this season. Three wins against three inferior teams is what the Nittany Lions have on their resume, and they have not even covered the spread in one of these games. 

Meanwhile, Oregon has been much more impressive, beating several Power 4 teams in dominant fashion. The Ducks’ offense has also been far more efficient, which includes a game where they scored 69 points against Oklahoma State.

This is, of course, a night game in Happy Valley, so Oregon will have to deal with a hostile crowd. That being said, they simply look to be the better team; therefore, our Oregon Ducks vs Penn State Nittany Lions prediction is: Oregon Ducks +3.5.

Prediction:

 

Oregon Ducks +3.5

-112
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oregon Ducks vs Penn State Nittany Lions Picks