Pittsburgh Pirates vs Athletics Prediction & Picks - MLB

Prediction published on 9/19/25, 2:52 PM  by Lou Aguila | Modified on 9/20/25 at 2:19 AM in MLB Picks

The Oakland Athletics will go for their seventh win in eight games as they kick off a fresh series with the Pittsburgh Pirates on Friday at PNC Park.

The Athletics, who have won by at least two runs in their last five meetings with the Pirates, offer a payout of $245 per $100 bet (+145) if they cover -1.5 runs again.

Current Form:

The Athletics (72-81) are 6-1 in their last seven games, having swept the Cincinnati Reds and taking three out of their last four games with the Boston Red Sox. Meanwhile, the Pirates (65-88) have lost their last four games, including a three-game sweep at the hands of the Chicago Cubs. Pittsburgh is also 1-11 in their last 12 games.

Stats in the last 5 games:

The Athletics have dominated from the mound in their last five games, commanding a 2.98 ERA and 1.26 WHIP. The A’s have also averaged 5.9 runs per game on a .278 batting average in this stretch. The Pirates have maintained their excellent pitching numbers despite their losing woes, sporting a 3.48 ERA in the last five games. Unfortunately, they are only averaging 2.6 runs per game on a .171 batting average in this 5-game spell.

Pitchers Matchup:

Athletics Luis Severino (6-11, 4.82 ERA) vs. Mitch Keller (6-14, 4.13 ERA).