Notre Dame Fighting Irish vs Pittsburgh Panthers Prediction & Picks - NCAA

USA - NCAA

Notre Dame Fighting Irish
11/15/25 12:00
Pittsburgh Panthers

Prediction:

 

Pittsburgh Panthers +12.5

-112
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 by Matt Lowrimore in NCAA Picks

One of the important games on the Week 12 College Football Saturday slate will see the 9th-ranked Notre Dame Fighting Irish take on the 22nd-ranked Pittsburgh Panthers. Let's take a look at the match statistics and predictions for this game between the Fighting Irish and the Panthers.

Notre Dame enters this game with a record of 7-2, having most recently beaten the Navy Midshipmen in Week 11 by a score of 49-10. The Fighting Irish offense had a total of 502 yards, while its defense allowed 228 yards. Quarterback CJ Carr threw for 218 yards and three touchdowns, while running back Jeremiah Love led the team in rushing with 94 yards and two touchdowns.

As for Pittsburgh, they enter this game with a record of 7-2, having most recently beaten the Stanford Cardinal in Week 10 by a score of 35-20. The Panthers' offense had a total of 466 yards, while its defense allowed 326 yards. Quarterback Mason Heintschel threw for 304 yards, three touchdowns, and two interceptions, while running back Ja'Kyrian Turner led the team in rushing with 127 yards.

Notre Dame Fighting Irish vs Pittsburgh Panthers Form

Table

Teams % P W D L
3
Pittsburgh Panthers
Pittsburgh Panthers
0.833 6 5 0 1
14
Notre Dame Fighting Irish
Notre Dame Fighting Irish
0.8 10 8 0 2

Notre Dame Fighting Irish and Pittsburgh Panthers Latest Matches

Notre Dame Fighting Irish
Notre Dame Fighting Irish Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 8, 2025 - NCAA

Navy Midshipmen
10 :  49
Notre Dame Fighting Irish

Nov 1, 2025 - NCAA

Notre Dame Fighting Irish
25 :  10
Boston College Eagles

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Oct 11, 2025 - NCAA

North Carolina State Wolfpack
7 :  36
Notre Dame Fighting Irish

Oct 4, 2025 - NCAA

Boise State Broncos
7 :  28
Notre Dame Fighting Irish

Sep 27, 2025 - NCAA

Notre Dame Fighting Irish
56 :  13
Arkansas Razorbacks
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 8, 2025 - NCAA

Navy Midshipmen
10 :  49
Notre Dame Fighting Irish

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Oct 11, 2025 - NCAA

North Carolina State Wolfpack
7 :  36
Notre Dame Fighting Irish

Oct 4, 2025 - NCAA

Boise State Broncos
7 :  28
Notre Dame Fighting Irish

Sep 20, 2025 - NCAA

Purdue Boilermakers
30 :  56
Notre Dame Fighting Irish

Sep 13, 2025 - NCAA

Texas AM Aggies
41 :  40
Notre Dame Fighting Irish
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 1, 2025 - NCAA

Notre Dame Fighting Irish
25 :  10
Boston College Eagles

Sep 27, 2025 - NCAA

Notre Dame Fighting Irish
56 :  13
Arkansas Razorbacks

Aug 31, 2025 - NCAA

Notre Dame Fighting Irish
24 :  27
Miami Hurricanes

Jan 9, 2025 - NCAA

Notre Dame Fighting Irish
27 :  24
Penn State Nittany Lions

Jan 2, 2025 - NCAA

Notre Dame Fighting Irish
23 :  10
Georgia Bulldogs

Nov 30, 2024 - NCAA

Notre Dame Fighting Irish
49 :  35
USC Trojans
Pittsburgh Panthers
Pittsburgh Panthers Latest matches
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 1, 2025 - NCAA

Pittsburgh Panthers
35 :  20
Stanford Cardinal

Oct 25, 2025 - NCAA

North Carolina State Wolfpack
34 :  53
Pittsburgh Panthers

Oct 18, 2025 - NCAA

Pittsburgh Panthers
30 :  13
Syracuse Orange

Oct 11, 2025 - NCAA

Pittsburgh Panthers
34 :  31
Florida State Seminoles

Oct 4, 2025 - NCAA

Boston College Eagles
7 :  48
Pittsburgh Panthers

Sep 27, 2025 - NCAA

Louisville Cardinals
34 :  27
Pittsburgh Panthers
L W W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 25, 2025 - NCAA

North Carolina State Wolfpack
34 :  53
Pittsburgh Panthers

Oct 4, 2025 - NCAA

Boston College Eagles
7 :  48
Pittsburgh Panthers

Sep 27, 2025 - NCAA

Louisville Cardinals
34 :  27
Pittsburgh Panthers

Sep 6, 2025 - NCAA

Central Michigan Chippewas
17 :  45
Pittsburgh Panthers

Aug 30, 2025 - NCAA

Duquesne Dukes
9 :  61
Pittsburgh Panthers

Nov 16, 2024 - NCAA

Clemson Tigers
24 :  20
Pittsburgh Panthers
L L L W W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 1, 2025 - NCAA

Pittsburgh Panthers
35 :  20
Stanford Cardinal

Oct 18, 2025 - NCAA

Pittsburgh Panthers
30 :  13
Syracuse Orange

Oct 11, 2025 - NCAA

Pittsburgh Panthers
34 :  31
Florida State Seminoles

Sep 13, 2025 - NCAA

Pittsburgh Panthers
24 :  31
West Virginia Mountaineers

Dec 26, 2024 - NCAA Division I, FBS, Playoffs

Pittsburgh Panthers
46 :  48
Toledo Rockets

Nov 30, 2024 - NCAA

Pittsburgh Panthers
23 :  34
Boston College Eagles

Notre Dame Fighting Irish - Pittsburgh Panthers Key Points

  1. Notre Dame is 4-5 ATS this season
  2. Notre Dame is averaging 38.7 points per game this season
  3. Pittsburgh is 7-2 ATS this season
  4. Pittsburgh is averaging 39.7 points per game this season

Our Notre Dame Fighting Irish vs Pittsburgh Panthers Prediction

The Fighting Irish continue to make their case for the College Football Playoffs and, as such, are double-digit favorites in this non-conference game against Pittsburgh. Despite winning last week against an overmatched Navy team, the Fighting Irish have still only covered the spread in four of their nine games.

Pittsburgh, on the other hand, has covered the spread in seven of their nine games. The Panthers have the advantage of playing this game at home and with an extra week of preparation. Pittsburgh is not likely to win this game, but given their success against the spread, our Notre Dame Fighting Irish vs Pittsburgh Panthers prediction is: Pittsburgh Panthers +12.5.

Prediction:

 

Pittsburgh Panthers +12.5

-112
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Notre Dame Fighting Irish vs Pittsburgh Panthers Picks