San Francisco Giants vs New York Yankees Prediction & Picks - MLB

USA - MLB

San Francisco Giants
3/27/26 16:35
New York Yankees

Prediction:

 

Yankees ML

-131
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 by Travis Pulver | in MLB Picks

The New York Yankees will face the Giants at Oracle Park in San Francisco, CA, this afternoon at 4:35 p.m. EST with coverage provided by ESPN Unlimited and MLB TV.

New York and San Francisco opened the 2026 MLB season when they faced off Wednesday night at Oracle Park. It was not a pretty night for the home team, as the lineup only generated three hits and never got close to scoring a run. Giants starter Logan Webb was chased after giving up nine hits and six earned runs in five innings. As for the Yankees, New York got the scoring started in the second inning when the lineup tagged Webb for five runs, giving the Yankees an early 5-0 lead. They added two more in the fifth to close out the scoring, making the final 7-0 for the Giants.  Max Fried went 6 1/3 innings, gave up two hits, no runs, and struck out four.

Much to the disappointment of fans everywhere, no home runs were hit in the season opener. Yankees slugger Aaron Judge was a massive disappointment, going 0-5 and striking out four times. Giancarlo Stanton had a solid day, going 2-4 with a run and an RBI.


 

San Francisco Giants vs New York Yankees Form

Table

Teams Pts P W L
5 New York Yankees
0.585 82 48 34
28 San Francisco Giants
0.415 82 34 48

San Francisco Giants and New York Yankees Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 25, 2026 - MLB

San Francisco Giants
0 :  7
New York Yankees

Mar 21, 2026 - MLB Spring Training

San Francisco Giants
10 :  7
Cleveland Guardians

Mar 20, 2026 - MLB Spring Training

Texas Rangers
6 :  5
San Francisco Giants

Mar 20, 2026 - MLB Spring Training

San Francisco Giants
5 :  2
Kansas City Royals

Mar 19, 2026 - MLB Spring Training

Colorado Rockies
11 :  14
San Francisco Giants

Mar 18, 2026 - MLB Spring Training

Los Angeles Dodgers
5 :  1
San Francisco Giants
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 25, 2026 - MLB

San Francisco Giants
0 :  7
New York Yankees

Mar 21, 2026 - MLB Spring Training

San Francisco Giants
10 :  7
Cleveland Guardians

Mar 20, 2026 - MLB Spring Training

San Francisco Giants
5 :  2
Kansas City Royals

Mar 15, 2026 - MLB Spring Training

San Francisco Giants
7 :  1
Milwaukee Brewers

Mar 14, 2026 - MLB Spring Training

San Francisco Giants
7 :  8
Arizona Diamondbacks

Mar 13, 2026 - MLB Spring Training

San Francisco Giants
1 :  6
Cincinnati Reds
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Mar 20, 2026 - MLB Spring Training

Texas Rangers
6 :  5
San Francisco Giants

Mar 19, 2026 - MLB Spring Training

Colorado Rockies
11 :  14
San Francisco Giants

Mar 18, 2026 - MLB Spring Training

Los Angeles Dodgers
5 :  1
San Francisco Giants

Mar 16, 2026 - MLB Spring Training

San Diego Padres
3 :  1
San Francisco Giants

Mar 13, 2026 - MLB Spring Training

Cincinnati Reds
1 :  0
San Francisco Giants

Mar 11, 2026 - MLB Spring Training

Kansas City Royals
2 :  5
San Francisco Giants
New York Yankees
New York Yankees Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 25, 2026 - MLB

San Francisco Giants
0 :  7
New York Yankees

Mar 24, 2026 - MLB Spring Training

Chicago Cubs
3 :  8
New York Yankees

Mar 23, 2026 - MLB Spring Training

Chicago Cubs
15 :  6
New York Yankees

Mar 22, 2026 - MLB Spring Training

New York Yankees
6 :  2
Philadelphia Phillies

Mar 21, 2026 - MLB Spring Training

Detroit Tigers
3 :  1
New York Yankees

Mar 20, 2026 - MLB Spring Training

New York Yankees
3 :  1
Baltimore Orioles
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 22, 2026 - MLB Spring Training

New York Yankees
6 :  2
Philadelphia Phillies

Mar 20, 2026 - MLB Spring Training

New York Yankees
3 :  1
Baltimore Orioles

Mar 19, 2026 - MLB Spring Training

New York Yankees
5 :  4
Baltimore Orioles

Mar 18, 2026 - MLB Spring Training

New York Yankees
1 :  0
Boston Red Sox

Mar 15, 2026 - MLB Spring Training

New York Yankees
1 :  12
Detroit Tigers

Mar 14, 2026 - MLB Spring Training

New York Yankees
4 :  6
Philadelphia Phillies
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Mar 25, 2026 - MLB

San Francisco Giants
0 :  7
New York Yankees

Mar 24, 2026 - MLB Spring Training

Chicago Cubs
3 :  8
New York Yankees

Mar 23, 2026 - MLB Spring Training

Chicago Cubs
15 :  6
New York Yankees

Mar 21, 2026 - MLB Spring Training

Detroit Tigers
3 :  1
New York Yankees

Mar 19, 2026 - MLB Spring Training

Toronto Blue Jays
11 :  0
New York Yankees

Mar 17, 2026 - MLB Spring Training

Tampa Bay Rays
2 :  3
New York Yankees

San Francisco Giants against New York Yankees : Head to Head (H2H)

San Francisco Giants

40 %

New York Yankees

60 %

Mar 25, 2026 - MLB

San Francisco Giants
0 :  7
New York Yankees

Apr 13, 2025 - MLB

New York Yankees
4 :  5
San Francisco Giants

Apr 12, 2025 - MLB

New York Yankees
8 :  4
San Francisco Giants

Apr 11, 2025 - MLB

New York Yankees
1 :  9
San Francisco Giants

May 31, 2024 - MLB

San Francisco Giants
2 :  6
New York Yankees

San Francisco Giants - New York Yankees Key Points

  1. The Yankees lead the all-time series vs. the Giants, 39-27-1.
  2. The Yankees were 80-89 against the run line last season; the Giants were 74-85.
  3. The OVER was 97-72 for the Yankees last season and 81-81 for the Giants.
  4. Betting Public: 88% of moneyline tickets and 89% of the handle are on the Yankees.

Our San Francisco Giants vs New York Yankees Prediction

After the hitting display the Yankees put on in the opener, it is easy to just get behind the Bronx Bombers without thinking about it too much. Cam Schlittler is scheduled to take the mound for New York (4-3, 2.96 ERA in 2025) while Robbie Ray (11-8, 3.65 ERA in 2025) will do so for San Francisco. We don’t have much to go on this season just yet. But because of the hitting display in the opener and Schlittler having pitched well last season in limited action, I’ve got to go with the Yankees.

Our New York vs. San Francisco: Yankees ML

Prediction:

 

Yankees ML

-131
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San Francisco Giants vs New York Yankees Picks