Minnesota Twins vs New York Yankees Prediction & Picks - MLB

Prediction published on 9/15/25, 4:06 PM  by Lou Aguila | Modified on 9/16/25 at 5:54 AM in MLB Picks

The New York Yankees are 9-1 in their last 10 meetings against the Minnesota Twins. They have also covered the spread in each of these 9 wins.

This head-to-head dominance makes the Yankees the overwhelming favorites ahead of Monday’s series opener against the Twins. New York is listed at -194 moneyline on DraftKings and also valued at -115 on the -1.5 run line.

Current Form:

The Yankees have gone 3-2 in their last five games after securing two wins against their rivals, the Boston Red Sox, in their weekend series. As a result, New York has reclaimed the No.2 spot in the AL East standings with an 83-66 record and established a 1.5-game lead on the Red Sox with only a handful of game days left in the regular-season calendar. Over the last five games, the Yankees have posted a 4.91 ERA and averaged 4.7 runs per game, which is slightly lower than their season average of 5.3 runs per game.

The Twins have only won once in their last five games, causing their record to plunge to 65-84. Minnesota, now officially out of the wild-card race, has averaged a decent 4.0 runs per game on a .237 batting average in its last five games. However, the Twins have also posted a measly 6.55 ERA in this stretch.