Baltimore Orioles vs New York Yankees Prediction & Picks - MLB

Prediction published on 9/21/25, 9:59 AM  by Lou Aguila | Modified on 9/22/25 at 9:38 AM in MLB Picks

After a convincing 6-1 win on Saturday, the New York Yankees have set their sights on winning the series against the Baltimore Orioles in Sunday’s Game 4 at Oriole Park.

The Yankees, who are 4-1 in their last five meetings with the Birds, are +122 on -1.5 runline.

Current Form:

The Yankees (87-68) are 4-1 in their last five games, pushing them within 2 games of the current AL East leaders Toronto Blue Jays (89-66). The Orioles are 3-5 in their last five games, but have lost 2 of the 3 games played in this ongoing series with the Yankees. Baltimore will miss this year’s postseason with a 73-82 record, last in the AL East.

Stats in the last 5 Games:

The Yankees have posted a 3.27 ERA and averaged 7.0 runs per game on a .305 batting average in the last five games. The Orioles have pitched to a modest 4.65 ERA over the last five games, though their offense has only produced an average of 3.3 runs per game in this five-game spell.

Pitchers Matchup: Yankees RHP Cam Schlitter (3-3, 3.41 ERA) vs. Orioles RHP Kyle Brandish (1-1, 2.45 ERA)

Schlitter has helped the Yankees to win in four of his last five starts, commanding a 3.07 ERA. Brandish sports a 2.45 ERA in his first four starts and has posted back-to-back games with one earned run each.