Buffalo Bills vs New Orleans Saints Prediction & Picks - NFL

USA - NFL

Buffalo Bills
9/28/25 13:00
New Orleans Saints

Prediction:

 

James Cook Anytime Touchdown

-175
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 by Matt Lowrimore | in NFL Picks

One of the games on the Week 4 Sunday NFL slate will feature a matchup between the Buffalo Bills and the New Orleans Saints. Let’s take a look at the match statistics and predictions for this game between the Bills and the Saints.

New Orleans enters this game with a record of 0-3, having most recently lost to the Seattle Seahawks in Week 3 by a score of 44-13. The Saints’ offense had a total of 284 yards, while its defense allowed 320 yards. Quarterback Spencer Rattler threw for 218 yards, one touchdown, and one interception, while running back Alvin Kamara led the team in rushing with 42 yards.

As for Buffalo, they enter this game with a record of 3-0, having most recently beaten the Miami Dolphins in Week 3 by a score of 31-21. The Bills’ offense had a total of 360 yards, while its defense allowed 276 yards. Quarterback Josh Allen threw for 213 yards and three touchdowns, while running back James Cook led the team in rushing with 108 yards and one touchdown.

Buffalo Bills vs New Orleans Saints Form

Table

Teams Pts P W L
8 Buffalo Bills
0.706 17 12 5
25 New Orleans Saints
0.353 17 6 11

Buffalo Bills and New Orleans Saints Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 19, 2025 - NFL

Buffalo Bills
27 :  25
Baltimore Ravens

Jan 12, 2025 - NFL

Buffalo Bills
31 :  7
Denver Broncos
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens

Jan 19, 2025 - NFL

Buffalo Bills
27 :  25
Baltimore Ravens

Jan 12, 2025 - NFL

Buffalo Bills
31 :  7
Denver Broncos

Dec 29, 2024 - NFL

Buffalo Bills
40 :  14
New York Jets

Dec 22, 2024 - NFL

Buffalo Bills
24 :  21
New England Patriots
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills

Dec 15, 2024 - NFL

Detroit Lions
42 :  48
Buffalo Bills

Dec 8, 2024 - NFL

Los Angeles Rams
44 :  42
Buffalo Bills

Nov 10, 2024 - NFL

Indianapolis Colts
20 :  30
Buffalo Bills
New Orleans Saints
New Orleans Saints Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Jan 5, 2025 - NFL

Tampa Bay Buccaneers
27 :  19
New Orleans Saints

Dec 29, 2024 - NFL

New Orleans Saints
10 :  25
Las Vegas Raiders

Dec 23, 2024 - NFL

Green Bay Packers
34 :  0
New Orleans Saints
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 29, 2024 - NFL

New Orleans Saints
10 :  25
Las Vegas Raiders

Dec 15, 2024 - NFL

New Orleans Saints
19 :  20
Washington Commanders

Nov 17, 2024 - NFL

New Orleans Saints
35 :  14
Cleveland Browns

Nov 10, 2024 - NFL

New Orleans Saints
20 :  17
Atlanta Falcons
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Jan 5, 2025 - NFL

Tampa Bay Buccaneers
27 :  19
New Orleans Saints

Dec 23, 2024 - NFL

Green Bay Packers
34 :  0
New Orleans Saints

Dec 8, 2024 - NFL

New York Giants
11 :  14
New Orleans Saints

Nov 3, 2024 - NFL

Carolina Panthers
23 :  22
New Orleans Saints

Oct 27, 2024 - NFL

Los Angeles Chargers
26 :  8
New Orleans Saints

Buffalo Bills - New Orleans Saints Key Points

  1. New Orleans has allowed 2 touchdowns to running backs this season
  2. New Orleans has allowed an average of 30.0 points per game this season
  3. Buffalo averages 34.0 points per game this season
  4. James Cook has scored 4 touchdowns this season

Our Buffalo Bills vs New Orleans Saints Prediction

Buffalo is a significant favorite in this game; therefore, backing either side on the spread looks to be too risky with how this game could play out. Instead, we will be looking for James Cook to score an anytime touchdown. 

Cook has had an electric start to the season, and as such, he has four touchdowns through the first three weeks. Cook has scored in all three of the Bills' games, that being in Week 1 against the Baltimore Ravens, two in Week 2 against the New York Jets, and one in Week 3 against the Miami Dolphins. 

He is a major part of the Bills’ offense and should find success against a struggling New Orleans side. For that reason, our Buffalo Bills vs New Orleans Saints prediction is: James Cook Anytime Touchdown.

Prediction:

 

James Cook Anytime Touchdown

-175
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Buffalo Bills vs New Orleans Saints Picks