San Francisco Giants vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

San Francisco Giants
9/23/26 15:45
Minnesota Twins

Prediction:

 

OVER 7.5

−118
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 by Travis Pulver | in MLB Picks

The San Francisco Giants (65-93, 37-40 Home) will go for the series win today when they host the Minnesota Twins (74-84, 34-46 Away) at Oracle Park. Fans can follow the action on MLB.TV once the game gets underway at 3:45 p.m. EST.

San Francisco got the series off to a good start on Monday with a 5-2 win over the visiting Twins. But Minnesota got the win yesterday in a close one, 3-2.

Cesar Perdomo is scheduled to get the start for the home team Giants. This will be just the fifth appearance for Perdomo, fourth as the “starter.” In his limited experience, he has gone 0-1 with a 3.72 ERA and a 1.50 WHIP. Teams have hit .293 against him. In his only other appearance at home (September 12 vs. San Diego), he got hit pretty hard, giving up ten hits and five earned runs in 4 2/3 innings.

As for the Twins, Minnesota is scheduled to go with Connor Prielipp to start the day. He has gone 6-7 in 23 appearances (21 starts) with a 4.94 ERA, 1.30 WHIP, and teams have hit .251 against him. When pitching on the road, he has posted a 1-4 record in 11 appearances (10 starts) with a 5.46 ERA and a .282 OBA.

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San Francisco Giants vs Minnesota Twins Form

Table

Teams Pts P W L
19 Minnesota Twins
0.475 162 77 85
27 San Francisco Giants
0.401 162 65 97

San Francisco Giants and Minnesota Twins Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2026 - MLB

San Francisco Giants
5 :  2
Minnesota Twins

Sep 20, 2026 - MLB

Los Angeles Dodgers
3 :  1
San Francisco Giants

Sep 19, 2026 - MLB

Los Angeles Dodgers
10 :  4
San Francisco Giants

Sep 18, 2026 - MLB

Los Angeles Dodgers
8 :  2
San Francisco Giants

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2026 - MLB

San Francisco Giants
5 :  2
Minnesota Twins

Sep 13, 2026 - MLB

San Francisco Giants
4 :  6
San Diego Padres

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Los Angeles Dodgers
3 :  1
San Francisco Giants

Sep 19, 2026 - MLB

Los Angeles Dodgers
10 :  4
San Francisco Giants

Sep 18, 2026 - MLB

Los Angeles Dodgers
8 :  2
San Francisco Giants

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants
Minnesota Twins
Minnesota Twins Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2026 - MLB

San Francisco Giants
5 :  2
Minnesota Twins

Sep 20, 2026 - MLB

Los Angeles Angels
0 :  8
Minnesota Twins

Sep 19, 2026 - MLB

Los Angeles Angels
6 :  5
Minnesota Twins

Sep 18, 2026 - MLB

Los Angeles Angels
0 :  3
Minnesota Twins

Sep 17, 2026 - MLB

Los Angeles Angels
5 :  4
Minnesota Twins

Sep 16, 2026 - MLB

Minnesota Twins
5 :  4
New York Yankees
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 16, 2026 - MLB

Minnesota Twins
5 :  4
New York Yankees

Sep 15, 2026 - MLB

Minnesota Twins
1 :  8
New York Yankees

Sep 14, 2026 - MLB

Minnesota Twins
3 :  8
New York Yankees

Sep 13, 2026 - MLB

Minnesota Twins
2 :  9
Cleveland Guardians

Sep 12, 2026 - MLB

Minnesota Twins
4 :  3
Cleveland Guardians

Sep 11, 2026 - MLB

Minnesota Twins
2 :  5
Cleveland Guardians
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 21, 2026 - MLB

San Francisco Giants
5 :  2
Minnesota Twins

Sep 20, 2026 - MLB

Los Angeles Angels
0 :  8
Minnesota Twins

Sep 19, 2026 - MLB

Los Angeles Angels
6 :  5
Minnesota Twins

Sep 18, 2026 - MLB

Los Angeles Angels
0 :  3
Minnesota Twins

Sep 17, 2026 - MLB

Los Angeles Angels
5 :  4
Minnesota Twins

Sep 9, 2026 - MLB

Detroit Tigers
7 :  2
Minnesota Twins

San Francisco Giants against Minnesota Twins : Head to Head (H2H)

San Francisco Giants

50 %

Minnesota Twins

50 %

Sep 21, 2026 - MLB

San Francisco Giants
5 :  2
Minnesota Twins

May 11, 2025 - MLB

Minnesota Twins
7 :  6
San Francisco Giants

May 9, 2025 - MLB

Minnesota Twins
3 :  1
San Francisco Giants

Jul 14, 2024 - MLB

San Francisco Giants
3 :  2
Minnesota Twins
San Francisco Giants vs Minnesota Twins Picks

San Francisco Giants - Minnesota Twins Key Points

  1. San Francisco is 39-53 in games following a loss; Minnesota is 34-39 in games following a win.
  2. San Francisco is 48-44 ATS (run line) in games following a loss; Minnesota is 38-35 ATS (run line) in games following a win.
  3. The OVER is 43-46-3 for the Giants following a loss and 37-31-5 in games following a win for the Twins.
  4. Betting Public: 74% of total tickets and 75% of the handle is on the OVER.

Our San Francisco Giants vs Minnesota Twins Prediction

I hesitate to go with the OVER for this game because neither team has been hitting all too well over the last week (Minnesota: .246 with 30 runs scored in seven games; San Francisco: .226 with 20 runs scored across six games). But I expect both lineups to wake up somewhat today with such lackluster pitching on the mound. It is hard to say who will win between two teams just looking for the season to end, but whoever does come out ahead will do so in a relatively high-scoring game.

Our Minnesota vs. San Francisco Pick: OVER 7.5

Prediction:

 

OVER 7.5

−118
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.