San Francisco Giants vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

San Francisco Giants
9/21/26 21:45
Minnesota Twins

Prediction:

 

Twins ML

−121
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 by Travis Pulver | in MLB Picks

The San Francisco Giants (64-92, 36-39 Home) will host the Minnesota Twins (73-88, 33-45 Away) in a three-game series this week starting today at Oracle Park. First Pitch for this matchup is scheduled for 9:45 p.m. EST.

This game marks the first of a 6-game homestand to end the Giants' season; they close with three games against the Los Angeles Dodgers. It will be the final road games of the season for the Twins. They close out the year with a three-game homestand against the Texas Rangers.

Zebby Matthews is scheduled to start today for the Twins. Mathews has gone 9-10 in 22 starts for Minnesota this season,  posting a 4.74 ERA and a 1.24 WHIP. Teams have hit .246 against him. On the road, he has gone 4-6 in 12 starts but posted a 6.93 ERA and a .270 OBA.

As for the Giants, San Francisco is scheduled to start relief pitcher Blade Tidwell. Tidwell has a 1-2 record with one save in 16 appearances and has started eight games. With 53 1/3 innings under his belt, he has posted a 4.56 ERA, a 1.20 WHIP, and teams have hit .223 against him his season. At home, he has pitched in eight games and has an ERA of 5.88.


 

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San Francisco Giants vs Minnesota Twins Form

Table

Teams Pts P W L
19 Minnesota Twins
0.475 162 77 85
27 San Francisco Giants
0.401 162 65 97

San Francisco Giants and Minnesota Twins Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Los Angeles Dodgers
3 :  1
San Francisco Giants

Sep 19, 2026 - MLB

Los Angeles Dodgers
10 :  4
San Francisco Giants

Sep 18, 2026 - MLB

Los Angeles Dodgers
8 :  2
San Francisco Giants

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2026 - MLB

San Francisco Giants
4 :  6
San Diego Padres

Sep 12, 2026 - MLB

San Francisco Giants
6 :  7
San Diego Padres

Sep 11, 2026 - MLB

San Francisco Giants
5 :  7
San Diego Padres

Sep 9, 2026 - MLB

San Francisco Giants
7 :  6
St. Louis Cardinals

Sep 8, 2026 - MLB

San Francisco Giants
2 :  1
St. Louis Cardinals

Sep 7, 2026 - MLB

San Francisco Giants
5 :  4
St. Louis Cardinals
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - MLB

Los Angeles Dodgers
3 :  1
San Francisco Giants

Sep 19, 2026 - MLB

Los Angeles Dodgers
10 :  4
San Francisco Giants

Sep 18, 2026 - MLB

Los Angeles Dodgers
8 :  2
San Francisco Giants

Sep 16, 2026 - MLB

St. Louis Cardinals
5 :  6
San Francisco Giants

Sep 15, 2026 - MLB

St. Louis Cardinals
3 :  10
San Francisco Giants

Sep 14, 2026 - MLB

St. Louis Cardinals
2 :  1
San Francisco Giants
Minnesota Twins
Minnesota Twins Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 20, 2026 - MLB

Los Angeles Angels
0 :  8
Minnesota Twins

Sep 19, 2026 - MLB

Los Angeles Angels
6 :  5
Minnesota Twins

Sep 18, 2026 - MLB

Los Angeles Angels
0 :  3
Minnesota Twins

Sep 17, 2026 - MLB

Los Angeles Angels
5 :  4
Minnesota Twins

Sep 16, 2026 - MLB

Minnesota Twins
5 :  4
New York Yankees

Sep 15, 2026 - MLB

Minnesota Twins
1 :  8
New York Yankees
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 16, 2026 - MLB

Minnesota Twins
5 :  4
New York Yankees

Sep 15, 2026 - MLB

Minnesota Twins
1 :  8
New York Yankees

Sep 14, 2026 - MLB

Minnesota Twins
3 :  8
New York Yankees

Sep 13, 2026 - MLB

Minnesota Twins
2 :  9
Cleveland Guardians

Sep 12, 2026 - MLB

Minnesota Twins
4 :  3
Cleveland Guardians

Sep 11, 2026 - MLB

Minnesota Twins
2 :  5
Cleveland Guardians
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 20, 2026 - MLB

Los Angeles Angels
0 :  8
Minnesota Twins

Sep 19, 2026 - MLB

Los Angeles Angels
6 :  5
Minnesota Twins

Sep 18, 2026 - MLB

Los Angeles Angels
0 :  3
Minnesota Twins

Sep 17, 2026 - MLB

Los Angeles Angels
5 :  4
Minnesota Twins

Sep 9, 2026 - MLB

Detroit Tigers
7 :  2
Minnesota Twins

Sep 8, 2026 - MLB

Detroit Tigers
2 :  3
Minnesota Twins

San Francisco Giants against Minnesota Twins : Head to Head (H2H)

San Francisco Giants

33 %

Minnesota Twins

67 %

May 11, 2025 - MLB

Minnesota Twins
7 :  6
San Francisco Giants

May 9, 2025 - MLB

Minnesota Twins
3 :  1
San Francisco Giants

Jul 14, 2024 - MLB

San Francisco Giants
3 :  2
Minnesota Twins
San Francisco Giants vs Minnesota Twins Picks

San Francisco Giants - Minnesota Twins Key Points

  1. Minnesota has a 4-2 record vs. the Giants over the last three seasons.
  2. The Giants have gone 40-35 ATS (run line) at home this season; Minnesota has gone 41-37 ATS (run line) on the road.
  3. The OVER is 36-35-4 for the Giants at home and 47-25-6 for the Twins on the road.
  4. Betting Public: 68% of moneyline tickets and 64% of the handle are on the Twins.

Our San Francisco Giants vs Minnesota Twins Prediction

The Giants are limping to the finish line this season and are coming off a sweep by the Dodgers in a series that saw them score a total of seven runs. Minnesota fared a bit better, winning two of three, but against the lowly Angels. Matthews is not a shutdown pitcher, but he is good enough to keep a struggling Giants lineup in check for the Twins to get the win.

Our Minnesota vs. San Francisco Pick: Twins ML

Prediction:

 

Twins ML

−121
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.