New York Mets vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

New York Mets
4/22/26 19:10
Minnesota Twins

Prediction:

 

Minnesota ML

+135
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 by Travis Pulver in MLB Picks

The New York Mets will try once again to bring their excruciating losing streak to an end Wednesday when they host the Minnesota Twins in Game Two of a three-game midweek series. First Pitch is scheduled for 7:10 p.m. EST at Citi Field in Queens, NY with coverage provided by MLB.TV.

For a few innings, there was reason to think the losing streak was going to end at 11 with a win on Tuesday. The Mets took a 3-0 lead in the bottom of the third, but then the Twins tacked on two in the sixth and a third in the seventh to tie things up. Minnesota took the lead with a pair of runs in the ninth, extending the Mets' losing streak to 12 games in a row.

No single aspect of the Mets game can be blamed for the streak; they’ve been bad all-around. Over the last 15 days (which includes their last win on April 7), the Mets' pitching staff has posted an ERA of 5.38; only the Phillies and Astros have been worse. As for their bats, they have hit .198 with just 26 runs batted in.

As of late Tuesday night, the Twins had yet to name a starting pitcher for Wednesday. But the Mets will send Clay Holmes to the mound. Holmes is 2-2 in four starts with a 1.96 ERA and a 1.09 WHIP.

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New York Mets vs Minnesota Twins Form

Table

Teams Pts P W L
22 Minnesota Twins
0.464 84 39 45
25 New York Mets
0.422 83 35 48

New York Mets and Minnesota Twins Latest Matches

New York Mets
New York Mets Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 21, 2026 - MLB

New York Mets
3 :  5
Minnesota Twins

Apr 19, 2026 - MLB

Chicago Cubs
2 :  1
New York Mets

Apr 18, 2026 - MLB

Chicago Cubs
4 :  2
New York Mets

Apr 17, 2026 - MLB

Chicago Cubs
12 :  4
New York Mets

Apr 15, 2026 - MLB

Los Angeles Dodgers
8 :  2
New York Mets

Apr 14, 2026 - MLB

Los Angeles Dodgers
2 :  1
New York Mets
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 21, 2026 - MLB

New York Mets
3 :  5
Minnesota Twins

Apr 12, 2026 - MLB

New York Mets
0 :  1
Athletics

Apr 11, 2026 - MLB

New York Mets
6 :  11
Athletics

Apr 10, 2026 - MLB

New York Mets
0 :  4
Athletics

Apr 9, 2026 - MLB

New York Mets
1 :  7
Arizona Diamondbacks

Apr 8, 2026 - MLB

New York Mets
2 :  7
Arizona Diamondbacks
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 19, 2026 - MLB

Chicago Cubs
2 :  1
New York Mets

Apr 18, 2026 - MLB

Chicago Cubs
4 :  2
New York Mets

Apr 17, 2026 - MLB

Chicago Cubs
12 :  4
New York Mets

Apr 15, 2026 - MLB

Los Angeles Dodgers
8 :  2
New York Mets

Apr 14, 2026 - MLB

Los Angeles Dodgers
2 :  1
New York Mets

Apr 13, 2026 - MLB

Los Angeles Dodgers
4 :  0
New York Mets
Minnesota Twins
Minnesota Twins Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 21, 2026 - MLB

New York Mets
3 :  5
Minnesota Twins

Apr 19, 2026 - MLB

Minnesota Twins
4 :  7
Cincinnati Reds

Apr 18, 2026 - MLB

Minnesota Twins
4 :  5
Cincinnati Reds

Apr 17, 2026 - MLB

Minnesota Twins
1 :  2
Cincinnati Reds

Apr 15, 2026 - MLB

Minnesota Twins
5 :  9
Boston Red Sox

Apr 14, 2026 - MLB

Minnesota Twins
6 :  0
Boston Red Sox
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 19, 2026 - MLB

Minnesota Twins
4 :  7
Cincinnati Reds

Apr 18, 2026 - MLB

Minnesota Twins
4 :  5
Cincinnati Reds

Apr 17, 2026 - MLB

Minnesota Twins
1 :  2
Cincinnati Reds

Apr 15, 2026 - MLB

Minnesota Twins
5 :  9
Boston Red Sox

Apr 14, 2026 - MLB

Minnesota Twins
6 :  0
Boston Red Sox

Apr 13, 2026 - MLB

Minnesota Twins
13 :  6
Boston Red Sox
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2026 - MLB

New York Mets
3 :  5
Minnesota Twins

Apr 12, 2026 - MLB

Toronto Blue Jays
2 :  8
Minnesota Twins

Apr 11, 2026 - MLB

Toronto Blue Jays
4 :  7
Minnesota Twins

Apr 10, 2026 - MLB

Toronto Blue Jays
10 :  4
Minnesota Twins

Apr 2, 2026 - MLB

Kansas City Royals
1 :  5
Minnesota Twins

Apr 1, 2026 - MLB

Kansas City Royals
13 :  9
Minnesota Twins

New York Mets against Minnesota Twins : Head to Head (H2H)

New York Mets

33 %

Minnesota Twins

67 %

Apr 21, 2026 - MLB

New York Mets
3 :  5
Minnesota Twins

Apr 16, 2025 - MLB

Minnesota Twins
4 :  3
New York Mets

Apr 15, 2025 - MLB

Minnesota Twins
6 :  3
New York Mets

Apr 14, 2025 - MLB

Minnesota Twins
1 :  5
New York Mets

Jul 31, 2024 - MLB

New York Mets
3 :  8
Minnesota Twins

Jul 30, 2024 - MLB

New York Mets
2 :  0
Minnesota Twins

New York Mets - Minnesota Twins Key Points

  1. The Mets lead the all-time series vs. the Twins, 18-13.
  2. The Mets are 2-10 ATS during this 12-game losing streak; the OVER is 6-6.
  3. Minnesota is 7-5 SU and ATS in their  last 12 games; the OVER is 9-3.
  4. Betting Public: 67% of moneyline tickets and 87% of the handle are on the Mets.
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Our New York Mets vs Minnesota Twins Prediction

I can kind of see why the betting has been so heavy on the Mets outright winning this game. Clay Holmes has done a pretty good job on the mound so far this season. If he can put together another solid outing, and if the lineup can generate a few runs, the stage is set for a win! Now, we don’t know for certain who the Twins will start, but rumor has it that Connor Prielipp has been called up for that purpose. Prielipp has been solid in AAA (2.30 ERA, 30.6% strikeout rate).  

So I see no reason to assume the Mets lineup will suddenly come to life. Consequently, the Twins ML is a great value play.

Our Twins vs. Mets pick: Minnesota ML

Prediction:

 

Minnesota ML

+135
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New York Mets vs Minnesota Twins Picks