Chicago White Sox vs Minnesota Twins Prediction & Picks - MLB
USA - MLB
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in MLB Picks
Joe Ryan has powered the Twins to victory in 3 of his last 4 starts. He’s set to take the mound again on Tuesday, with Minnesota carrying a -115 price on the moneyline in Game 2 of the series against the Chicago White Sox.
Momentum: The Minnesota Twins’ four-game winning streak came to an end following a 3-1 loss to the Chicago White Sox in Monday’s series opener. Regardless, winning six of their last eight games has helped the Twins move within two games of .500 at 26-28.
On the other hand, the win snapped the White Sox’s two-game losing streak. Chicago also improved one game above .500 at 27-26, which puts them in second place behind AL Central leaders, the 32-24 Cleveland Guardians.
Matchup & Odds Analysis: The White Sox extended their dominance over the Twins to seven consecutive wins. In their last three meetings, Chicago has averaged 6.00 runs per game and held Minnesota to 4.00 runs per game.
The White Sox will once again walk onto the field as the underdog despite their head-to-head dominance. Caesars Sportsbook lists Chicago at -105 moneyline and -178 to cover the +1.5-run line.
White Sox RHP Sean Burke (2-3, 4.08 ERA) has not delivered a win for his team in his last three starts. He also gave up six earned runs over 4.1 innings in his first and only start against the Twins on April 2, 2025. Chicago lost the game 1-6.
The Twins will enter Game 2 as slight favorites as they will be starting Joe Ryan (3-3, 3.02 ERA), who has surrendered one earned run in each of his last three starts. Ryan has also powered the Twins to victory in his last three starts against the White Sox.
Limited Offer. Currently at Caesars Sportsbook
Chicago White Sox vs Minnesota Twins Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
10
|
0.521 | 117 | 61 | 56 |
|
16
|
0.492 | 120 | 59 | 61 |
Chicago White Sox and Minnesota Twins Latest Matches
3/6 (50%)
3/6 (50%)
May 25, 2026 - MLB
May 24, 2026 - MLB
May 23, 2026 - MLB
May 22, 2026 - MLB
May 20, 2026 - MLB
May 19, 2026 - MLB
5/6 (83%)
1/6 (17%)
May 25, 2026 - MLB
May 17, 2026 - MLB
May 16, 2026 - MLB
May 15, 2026 - MLB
May 14, 2026 - MLB
May 13, 2026 - MLB
2/6 (33%)
4/6 (67%)
May 24, 2026 - MLB
May 23, 2026 - MLB
May 22, 2026 - MLB
May 20, 2026 - MLB
May 19, 2026 - MLB
May 18, 2026 - MLB
4/6 (67%)
2/6 (33%)
May 25, 2026 - MLB
May 24, 2026 - MLB
May 23, 2026 - MLB
May 22, 2026 - MLB
May 20, 2026 - MLB
May 19, 2026 - MLB
3/6 (50%)
3/6 (50%)
May 20, 2026 - MLB
May 19, 2026 - MLB
May 18, 2026 - MLB
May 17, 2026 - MLB
May 16, 2026 - MLB
May 15, 2026 - MLB
5/6 (83%)
1/6 (17%)
May 25, 2026 - MLB
May 24, 2026 - MLB
May 23, 2026 - MLB
May 22, 2026 - MLB
May 10, 2026 - MLB
May 9, 2026 - MLB
Chicago White Sox against Minnesota Twins : Head to Head (H2H)
100 %
0 %
May 25, 2026 - MLB
Sep 4, 2025 - MLB
Sep 3, 2025 - MLB
Sep 2, 2025 - MLB
Sep 1, 2025 - MLB
Aug 24, 2025 - MLB
Chicago White Sox - Minnesota Twins Key Points
- Minnesota is 4-1 SU in its last 5 games.
- Minnesota is 5-1 SU in its last 6 games on the road.
- Chicago White Sox is 6-12 SU in its last 18 games when playing at home against Minnesota.
- Chicago White Sox is 10-5 SU in its last 15 games.
Limited Offer. Currently at Caesars Sportsbook
Our Chicago White Sox vs Minnesota Twins Prediction
Fearless Forecast: Joe Ryan silences White Sox’s offense, leads the Twins to a comfortable win.
Back the Twins to cover -1.5 runs (+150). Despite their 7-0 record in their last seven meetings against the Twins, the White Sox understand that they will be in a tough contest in Game 2 with Joe Ryan scheduled to take the mound.
Ryan has waited almost two years to face the White Sox again, and it comes at a time when the Twins pitcher has been dominating teams left and right. Ryan has posted three consecutive starts where he surrendered one earned run over six innings, lowering his ERA to 1.85 over his last five starts.
Meanwhile, White Sox starter Sean Burke has conceded 12 earned runs over his last 12.4 innings on the mound. Over their last five games, Chicago has posted a 6.00 ERA, with their bullpen allowing a 6.64 ERA.
Our betting prediction for the Minnesota Twins vs. the Chicago White Sox: The Twins -1.5 runsCaesars Rewards Program
Caesars Sportsbook really spoils new users with an awesome rewards program, making every wager count towards something bigger! Available for users across the country, this program is a bettor's dream. As you enjoy the thrills of sports betting or casino games online, you can earn up to 10 Reward Credits for every $100 wagered on straight bets. And if parlays are more your style, you'll earn up to 20 Reward Credits for every $100 wagered. With Caesars Sportsbook, your bets not only bring the excitement of the game but also the joy of accumulating rewards that enhance your gaming experience. Play now and let Caesars treat you like royalty with each bet you place!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
