Chicago White Sox vs Minnesota Twins Prediction & Picks - MLB

Prediction published on 5/25/26, 10:59 AM  by Lou Aguila | Modified on 5/26/26 at 4:53 PM in MLB Picks

The over 8.0 runs set for Game 1 between the Minnesota Twins and the Chicago White Sox is shaping up to be a sure thing, since the total has gone over in 5 of the last 7 games featuring these two teams

Momentum: The Minnesota Twins have won their last four games, highlighted by their three-game sweep of the Boston Red Sox. Now at 26-27, Minnesota is now one win away from reaching .500 for the first time since they held a 12-12 record on April 22.

The Chicago White Sox have lost three of their last four games, including back-to-back defeats at the hands of the San Francisco Giants. The White Sox occupy the No.2 spot in the AL Central with a 26-26 record, a half game ahead of Minnesota and 4.5 games behind the division leaders, the 32-23 Cleveland Guardians.

The Matchup: The White Sox have won 7 of their last 10 meetings with the Twins. They have also defeated Minnesota in their last 6 meetings. The White Sox have outscored the Twins in their most recent series, averaging 9.00 runs per game while stifling Minnesota to 4.6 runs per contest.

Starting Pitchers: Twins RHP Zebby Matthews (1-1, 1.38 ERA) vs. White Sox LHP (3-1, 4.27 ERA).

Hot on the Board: Caesars Sportsbook is anticipating a hard-fought series opener with the streaking Twins emerging as slight favorites at -115 and the White Sox carrying an underdog price of -105. The over/under stands at a modest 8.0 runs.