Chicago White Sox vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

Chicago White Sox
8/22/25 19:40
Minnesota Twins

Prediction:

 

The Twins will win

-139
$200 offered for betting!

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 by Lou Aguila | in MLB Picks

Booked as -139 favorites at DraftKings, the Minnesota Twins eye their 9th win in their last 11 meetings against the Chicago White Sox on Friday at Rate Field.

The Twins were on the receiving end of a three-game sweep against the Athletics this week. Only a miracle now can send Minnesota back to the postseason after compiling 58-69 in the season, fourth in the AL Central. Moreover, the Twins are missing the service of one of their most reliable hurlers, Simeon Woods-Richardson, who is still on the 15-day IL due to illness.

Similar to the Twins, the White Sox are now out of the postseason race after amassing only 45 wins this late in the season. Chicago is dead last in the AL Central record with a 45-82 record. The White Sox fall in the bottom percentile in both key offense and pitching categories. They rank 27th in total runs (490), 29th in batting average (.231), 19th in ERA (4.18), and 25th in WHIP (1.37).

Chicago White Sox vs Minnesota Twins Form

Table

Teams Pts P W L
27 Minnesota Twins
0.432 162 70 92
29 Chicago White Sox
0.37 162 60 102

Chicago White Sox and Minnesota Twins Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Atlanta Braves
1 :  0
Chicago White Sox

Aug 19, 2025 - MLB

Atlanta Braves
11 :  10
Chicago White Sox

Aug 18, 2025 - MLB

Atlanta Braves
9 :  13
Chicago White Sox

Aug 17, 2025 - MLB

Kansas City Royals
6 :  2
Chicago White Sox

Aug 16, 2025 - MLB

Kansas City Royals
6 :  2
Chicago White Sox

Aug 15, 2025 - MLB

Kansas City Royals
3 :  1
Chicago White Sox
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 13, 2025 - MLB

Chicago White Sox
0 :  1
Detroit Tigers

Aug 12, 2025 - MLB

Chicago White Sox
9 :  6
Detroit Tigers

Aug 11, 2025 - MLB

Chicago White Sox
1 :  2
Detroit Tigers

Aug 10, 2025 - MLB

Chicago White Sox
6 :  4
Cleveland Guardians

Aug 9, 2025 - MLB

Chicago White Sox
1 :  3
Cleveland Guardians

Aug 8, 2025 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Atlanta Braves
1 :  0
Chicago White Sox

Aug 19, 2025 - MLB

Atlanta Braves
11 :  10
Chicago White Sox

Aug 18, 2025 - MLB

Atlanta Braves
9 :  13
Chicago White Sox

Aug 17, 2025 - MLB

Kansas City Royals
6 :  2
Chicago White Sox

Aug 16, 2025 - MLB

Kansas City Royals
6 :  2
Chicago White Sox

Aug 15, 2025 - MLB

Kansas City Royals
3 :  1
Chicago White Sox
Minnesota Twins
Minnesota Twins Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 21, 2025 - MLB

Minnesota Twins
3 :  8
Athletics

Aug 20, 2025 - MLB

Minnesota Twins
2 :  4
Athletics

Aug 19, 2025 - MLB

Minnesota Twins
3 :  6
Athletics

Aug 17, 2025 - MLB

Minnesota Twins
8 :  1
Detroit Tigers

Aug 16, 2025 - MLB

Minnesota Twins
5 :  8
Detroit Tigers

Aug 15, 2025 - MLB

Minnesota Twins
0 :  7
Detroit Tigers
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 21, 2025 - MLB

Minnesota Twins
3 :  8
Athletics

Aug 20, 2025 - MLB

Minnesota Twins
2 :  4
Athletics

Aug 19, 2025 - MLB

Minnesota Twins
3 :  6
Athletics

Aug 17, 2025 - MLB

Minnesota Twins
8 :  1
Detroit Tigers

Aug 16, 2025 - MLB

Minnesota Twins
5 :  8
Detroit Tigers

Aug 15, 2025 - MLB

Minnesota Twins
0 :  7
Detroit Tigers
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 13, 2025 - MLB

New York Yankees
1 :  4
Minnesota Twins

Aug 12, 2025 - MLB

New York Yankees
9 :  1
Minnesota Twins

Aug 11, 2025 - MLB

New York Yankees
6 :  2
Minnesota Twins

Aug 6, 2025 - MLB

Detroit Tigers
4 :  9
Minnesota Twins

Aug 5, 2025 - MLB

Detroit Tigers
3 :  6
Minnesota Twins

Aug 4, 2025 - MLB

Detroit Tigers
6 :  3
Minnesota Twins

Chicago White Sox against Minnesota Twins : Head to Head (H2H)

Chicago White Sox

33 %

Minnesota Twins

67 %

Apr 24, 2025 - MLB

Minnesota Twins
0 :  3
Chicago White Sox

Apr 23, 2025 - MLB

Minnesota Twins
6 :  3
Chicago White Sox

Apr 22, 2025 - MLB

Minnesota Twins
4 :  2
Chicago White Sox

Apr 2, 2025 - MLB

Chicago White Sox
1 :  6
Minnesota Twins

Apr 1, 2025 - MLB

Chicago White Sox
3 :  8
Minnesota Twins

Mar 31, 2025 - MLB

Chicago White Sox
9 :  0
Minnesota Twins

Chicago White Sox - Minnesota Twins Key Points

  1. Minnesota is 17-3 SU in its last 20 games against Chicago White Sox.
  2. Minnesota is 8-2 SU in its last 10 games when playing on the road against Chicago White Sox.
  3. Chicago White Sox is 1-6 SU in its last 7 games.
  4. Chicago White Sox is 2-4 SU in its last 6 games at home.

Our Chicago White Sox vs Minnesota Twins Prediction

Pick Minnesota to win.

The Twins are 17-3 SU in its last 20 games against Chicago White Sox. They are 8-2 SU in its last 10 games when playing on the road against the White Sox. I also think projected Twins starter Zeb Matthews will win his duel with White Sox starter Sean Burke, who is expected to make his first start since his triple-A stint. Matthews is not giving up too many runs recently, averaging 2.2 earned runs per game.

Moreover, the Twins could also take advantage of a horrendous White Sox bullpen that has given up a 12.46 ERA in their last five games. I could also pick the Twins -1.5 runs for more profits at +121, but I am hesitant to go all in because the White Sox have also been strong against the spread when playing teams from their division (12-8 ATS).

Our betting prediction for the Minnesota Twins vs. the Chicago White Sox: the Twins will win.

Prediction:

 

The Twins will win

-139
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago White Sox vs Minnesota Twins Picks