Pittsburgh Pirates vs Milwaukee Brewers Prediction & Picks - MLB

Prediction published on 5/25/25, 10:17 AM  by Carlos Zabala | Modified on 5/25/25 at 4:45 PM in MLB Picks

The Pirates won back-to-back games in 2025, now leading the four-game series 2-1 over the Brewers, which will be finalized Sunday afternoon at PNC Park.

The Bucks won on Friday and Saturday, and the main factor behind those victories was their star, Oneil Cruz, who had the first multi-home run game of his MLB career on Friday and on Saturday hit a key RBI triple to allow Kiner-Falefa to score the winning run in a 2-1 Pirates final score. Keller pitched a strong game, striking out seven, and Bednar recorded his fifth save.

However, bookmakers are leaning toward setting the Brewers as favorites at odds of around -130 to win Game 4, given that Henderson, with a 3-0 record and a 1.69 ERA, will be starting for them. Henderson is a rookie who took MLB by storm, earning a W in each of his first three MLB starts so far and striking out no fewer than 7 in each of them.