Chicago Cubs vs Milwaukee Brewers Prediction & Picks - MLB

Prediction published on 8/21/25, 10:42 AM  by Lou Aguila | Modified on 8/22/25 at 7:38 AM in MLB Picks

The Chicago Cubs will try to deliver the coup de grâce to the Milwaukee Bucks after winning the last three games of their five-game series at Wrigley Field.

The Brewers, the No.1 team in the NL Central, opened as +113 underdogs against the No.2 team in the division, the Cubs.

The Cubs have won the last three games after suffering an embarrassing 0-7 loss in the series opener earlier this week. Chicago silenced the high-powered Brewers offense, which averaged 10 runs a game last week, by holding them to 3.75 runs per game through the first four games of this crucial five-game showpiece. The Cubs only averaged 4.0 runs per game over the last five games, but they always found ways to come through with clutch hits in pivotal moments of this series.

After tormenting teams with their high-octane plays through the first two weeks of August, the Brewers’ offense has slowed down this week, averaging 3.3 runs over the last five games. Milwaukee’s pitching numbers are still elite with a 2.76 ERA over the five-game stretch, though there is a slight jump in the ERA of the starters, who are giving up a 4.21 ERA after maintaining a sub-2.00 ERA during their 14-game winning run.